A comparison of Freesurfer and multi-atlas MUSE for brain anatomy segmentation: Findings about size and age bias, and inter-scanner stability in multi-site aging studies.
Srinivasan, D., et al.
2020,
BMC bioinformatics
Deep learning detection of informative features in tau PET for Alzheimer's disease classification.
Jo, T., et al.
2020,
European journal of human genetics : EJHG
A quantitative trait rare variant nonparametric linkage method with application to age-at-onset of Alzheimer's disease.
Zhao, L., et al.
2020,
Neurology
C9orf72, age at onset, and ancestry help discriminate behavioral from language variants in FTLD cohorts.
Costa, B., et al.
2020,
Journal of aging and health
Family Ties and Aging in a Multiethnic Cohort.
Ying, G., et al.
2020,
Alzheimer's & dementia : the journal of the Alzheimer's Association
Dietary fatty acids and risk of Alzheimer's disease and related dementias: Observations from the Washington Heights-Hamilton Heights-Inwood Columbia Aging Project (WHICAP).
Gustafson, DR., et al.
2020,
Neuromolecular medicine
Transcriptomic Heterogeneity of Alzheimer's Disease Associated with Lipid Genetic Risk.
Miao, X., et al.
2020,
NeuroImage
Implicating causal brain imaging endophenotypes in Alzheimer's disease using multivariable IWAS and GWAS summary data.
Knutson, KA., et al.
2020,
Brain : a journal of neurology
rs34331204 regulates TSPAN13 expression and contributes to Alzheimer's disease with sex differences.
Hu, Y., et al.
2020,
Trends in neurosciences
Microglial Phagocytosis: A Disease-Associated Process Emerging from Alzheimer's Disease Genetics.
Podleśny-Drabiniok, A., et al.
2020,
Science translational medicine
Chi3l1/YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer's disease pathogenesis.
Lananna, BV., et al.
2020,
Neurology
Association of common genetic variants with brain microbleeds: A genome-wide association study.
Knol, MJ., et al.
2020,
Nature communications
Cerebral small vessel disease genomics and its implications across the lifespan.
Sargurupremraj, M., et al.
2020,
IEEE transactions on medical imaging
Associating Multi-Modal Brain Imaging Phenotypes and Genetic Risk Factors via a Dirty Multi-Task Learning Method.
Du, L., et al.
2020,
Acta neuropathologica communications
Functional genomic analyses uncover APOE-mediated regulation of brain and cerebrospinal fluid beta-amyloid levels in Parkinson disease.
Ibanez, L., et al.
2020,
JAMA network open
Assessment of Leisure Time Physical Activity and Brain Health in a Multiethnic Cohort of Older Adults.
Gu, Y., et al.
2020,
Science translational medicine
Sampling interstitial fluid from human skin using a microneedle patch.
Samant, PP., et al.
2020,
Nature communications
Epigenome-wide meta-analysis of DNA methylation differences in prefrontal cortex implicates the immune processes in Alzheimer's disease.
Zhang, L., et al.
2020,
Molecular psychiatry
Genetic data and cognitively defined late-onset Alzheimer's disease subgroups.
Mukherjee, S., et al.
2020,
Molecular psychiatry
Correction: Genetic data and cognitively defined late-onset Alzheimer's disease subgroups.
Mukherjee, S., et al.
2020,
Acta neuropathologica
Distinct clinicopathologic clusters of persons with TDP-43 proteinopathy.
Katsumata, Y., et al.
2020,
Scientific reports
Genetic and non-genetic factors associated with the phenotype of exceptional longevity & normal cognition.
Han, B., et al.
2020,
Nature communications
Molecular estimation of neurodegeneration pseudotime in older brains.
Mukherjee, S., et al.
2020,
NeuroImage
Brain extraction on MRI scans in presence of diffuse glioma: Multi-institutional performance evaluation of deep learning methods and robust modality-agnostic training.
Thakur, S., et al.
2020,
Proceedings of SPIE--the International Society for Optical Engineering
Patch-Based Surface Morphometry Feature Selection with Federated Group Lasso Regression.
Wu, J., et al.
2020,
Proceedings. IEEE International Symposium on Bioinformatics and Bioengineering
Deep Multiview Learning to Identify Population Structure with Multimodal Imaging.
Feng, Y., et al.
2020,
Machine learning in medical imaging. MLMI (Workshop)
A Deep Network for Joint Registration and Reconstruction of Images with Pathologies.
Han, X., et al.
2020,
The journals of gerontology. Series A, Biological sciences and medical sciences
Parental History of Dementia Is Associated with Increased Small Vessel Cerebrovascular Disease.
Stamm, BC., et al.
2020,
Alzheimer's & dementia : the journal of the Alzheimer's Association
Vitamin D intake is associated with dementia risk in the Washington Heights-Inwood Columbia Aging Project (WHICAP).
Zhao, C., et al.
2020,
Nature
Negative feedback control of neuronal activity by microglia.
Badimon, A., et al.
2020,
Aging cell
Underlying features of epigenetic aging clocks in vivo and in vitro.
Liu, Z., et al.
2020,
Acta neuropathologica
ADNC-RS, a clinical-genetic risk score, predicts Alzheimer's pathology in autopsy-confirmed Parkinson's disease and Dementia with Lewy bodies.
Dai, DL., et al.
2020,
Human molecular genetics
Integrative genomics approach identifies conserved transcriptomic networks in Alzheimer's disease.
Morabito, S., et al.
2020,
American journal of human genetics
Bayesian Genome-wide TWAS Method to Leverage both cis- and trans-eQTL Information through Summary Statistics.
Luningham, JM., et al.
2020,
Scientific data
Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions.
Sieberts, SK., et al.
2020,
Science advances
The FAM171A2 gene is a key regulator of progranulin expression and modifies the risk of multiple neurodegenerative diseases.
Xu, W., et al.
2020,
JAMA network open
Association of Uncommon, Noncoding Variants in the APOE Region With Risk of Alzheimer Disease in Adults of European Ancestry.
Blue, EE., et al.
2020,
Nature genetics
An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer's disease.
Nativio, R., et al.
2020,
Acta neuropathologica
TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis.
Cignarella, F., et al.
2020,
JAMA neurology
Assessment of Incidence and Risk Factors of Intracerebral Hemorrhage Among Participants in the Framingham Heart Study Between 1948 and 2016.
Lioutas, V., et al.
2020,
Genetic epidemiology
Evaluation of population stratification adjustment using genome-wide or exonic variants.
Chen, Y., et al.
2020,
Journal of the American Heart Association
Growth Differentiation Factor 15 and NT-proBNP as Blood-Based Markers of Vascular Brain Injury and Dementia.
McGrath, ER., et al.
2020,
EMBO molecular medicine
Higher CSF sTREM2 and microglia activation are associated with slower rates of beta-amyloid accumulation.
Ewers, M., et al.
2020,
NeuroImage
Increased power by harmonizing structural MRI site differences with the ComBat batch adjustment method in ENIGMA.
Radua, J., et al.
2020,
Alzheimer's & dementia : the journal of the Alzheimer's Association
Analysis of brain region-specific co-expression networks reveals clustering of established and novel genes associated with Alzheimer disease.
Lancour, D., et al.
2020,
Hypertension (Dallas, Tex. : 1979)
Mid to Late Life Hypertension Trends and Cerebral Small Vessel Disease in the Framingham Heart Study.
Petrea, RE., et al.
2020,
American journal of human genetics
Evolution of a Human-Specific Tandem Repeat Associated with ALS.
Course, MM., et al.
2020,
Neurobiology of aging
Degree of genetic liability for Alzheimer's disease associated with specific proteomic profiles in cerebrospinal fluid.
Reus, LM., et al.
2020,
Neurology
Physical activity and risk of Alzheimer disease: A 2-sample mendelian randomization study.
Baumeister, SE., et al.
2020,
Genetic epidemiology
Fine-mapping and QTL tissue-sharing information improves the reliability of causal gene identification.
Barbeira, AN., et al.
2020,
Neurobiology of disease
Genetic architecture of Alzheimer's disease.
Neuner, SM., et al.
2020,
Neurobiology of disease
Identification and genomic analysis of pedigrees with exceptional longevity identifies candidate rare variants.
Miller, JB., et al.
2020,
Nature communications
Risk prediction of late-onset Alzheimer's disease implies an oligogenic architecture.
Zhang, Q., et al.
2020,
Molecular and cellular biology
Endosomal Trafficking in Alzheimer's Disease, Parkinson's Disease, and Neuronal Ceroid Lipofuscinosis.
Qureshi, YH., et al.
2020,
Cell reports
Cross-Species Analyses Identify Dlgap2 as a Regulator of Age-Related Cognitive Decline and Alzheimer's Dementia.
Ouellette, AR., et al.
2020,
Neurology
Cardiovascular health, genetic risk, and risk of dementia in the Framingham Heart Study.
Peloso, GM., et al.
2020,
Nature communications
Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults.
Hofer, E., et al.
2020,
Journal of the American Geriatrics Society
Introduction to LASI-DAD: The Longitudinal Aging Study in India-Diagnostic Assessment of Dementia.
Lee, J.
2020,
Journal of the American Geriatrics Society
Design and Methodology of the Longitudinal Aging Study in India-Diagnostic Assessment of Dementia (LASI-DAD).
Lee, J., et al.
2020,
Journal of the American Geriatrics Society
Association Between Episodic Memory and Genetic Risk Factors for Alzheimer's Disease in South Asians from the Longitudinal Aging Study in India-Diagnostic Assessment of Dementia (LASI-DAD).
Smith, JA., et al.
2020,
Genome biology
PSCAN: Spatial scan tests guided by protein structures improve complex disease gene discovery and signal variant detection.
Tang, Z., et al.
2020,
Brain : a journal of neurology
Genetic variants and functional pathways associated with resilience to Alzheimer's disease.
Dumitrescu, L., et al.
2020,
Clinical epigenetics
The fusiform gyrus exhibits an epigenetic signature for Alzheimer's disease.
Ma, D., et al.
2020,
Alzheimer's & dementia : the journal of the Alzheimer's Association
Genome-wide association study of rate of cognitive decline in Alzheimer's disease patients identifies novel genes and pathways.
Sherva, R., et al.
2020,
Neurology
Twenty-seven-year time trends in dementia incidence in Europe and the United States: The Alzheimer Cohorts Consortium.
Wolters, FJ., et al.
2020,
Molecular psychiatry
Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation.
Bis, JC., et al.
2020,
Neurology. Genetics
Synonymous variants associated with Alzheimer disease in multiplex families.
Tang, M., et al.
2020,
Brain : a journal of neurology
Reply: CYLD variants in frontotemporal dementia associated with severe memory impairment in a Portuguese cohort.
Oyston, LJ., et al.
2020,
Nature
Mapping and characterization of structural variation in 17,795 human genomes.
Abel, HJ., et al.
2020,
Journal of the American Geriatrics Society
Interplay between Socioeconomic Markers and Polygenic Predisposition on Timing of Dementia Diagnosis.
Ajnakina, O., et al.
2020,
Alzheimer's & dementia : the journal of the Alzheimer's Association
MAPT haplotype-stratified GWAS reveals differential association for AD risk variants.
Strickland, SL., et al.
2020,
Brain : a journal of neurology
Sex-dependent autosomal effects on clinical progression of Alzheimer's disease.
Fan, CC., et al.
2020,
Molecular neurodegeneration
Deciphering cellular transcriptional alterations in Alzheimer's disease brains.
Wang, X., et al.
2020,
Cell reports
Meta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models.
Wan, Y., et al.
2020,
Annals of clinical and translational neurology
Relation of plasma β-amyloid, clusterin, and tau with cerebral microbleeds: Framingham Heart Study.
Romero, JR., et al.
2020,
Translational psychiatry
Genome-wide association study of cognitive function in diverse Hispanics/Latinos: results from the Hispanic Community Health Study/Study of Latinos.
Jian, X., et al.
2020,
An international journal on information fusion
Autosomal Dominantly Inherited Alzheimer Disease: Analysis of genetic subgroups by Machine Learning.
Castillo-Barnes, D., et al.
2020,
Alcohol (Fayetteville, N.Y.)
Interaction effect of alcohol consumption and Alzheimer disease polygenic risk score on the brain cortical thickness of cognitively normal subjects.
Matloff, WJ., et al.
2020,
PLoS genetics
Transcriptomic stratification of late-onset Alzheimer's cases reveals novel genetic modifiers of disease pathology.
Milind, N., et al.
2020,
Bioinformatics (Oxford, England)
SparkINFERNO: a scalable high-throughput pipeline for inferring molecular mechanisms of non-coding genetic variants.
Kuksa, PP., et al.
2020,
Neurobiology of disease
Systematic validation of variants of unknown significance in APP, PSEN1 and PSEN2.
Hsu, S., et al.
2020,
Acta neuropathologica
rs4147929 variant minor allele increases ABCA7 gene expression and ABCA7 shows increased gene expression in Alzheimer's disease patients compared with controls.
Liu, G., et al.
2020,
Neurobiology of aging
Failure to detect synergy between variants in transferrin and hemochromatosis and Alzheimer's disease in large cohort.
Vance, E., et al.
2020,
Nature medicine
Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation.
Johnson, ECB., et al.
2020,
Diabetologia
Neurocognitive impairment in type 2 diabetes: evidence for shared genetic aetiology.
Mollon, J., et al.
2020,
Nutrients
Proteomic and Metabolomic Correlates of Healthy Dietary Patterns: The Framingham Heart Study.
Walker, ME., et al.
2020,
Obesity reviews : an official journal of the International Association for the Study of Obesity
Association of anthropometry and weight change with risk of dementia and its major subtypes: A meta-analysis consisting 2.8 million adults with 57 294 cases of dementia.
Lee, CM., et al.
2020,
The Journal of nervous and mental disease
A Critical Review of Behavioral and Emotional Disinhibition.
Huey, ED.
2020,
Alzheimer's research & therapy
An analysis of genetically regulated gene expression across multiple tissues implicates novel gene candidates in Alzheimer's disease.
Gerring, ZF., et al.
2020,
Nature communications
Accurate estimation of cell composition in bulk expression through robust integration of single-cell information.
Jew, B., et al.
2020,
The Lancet. Neurology
Interpretation of risk loci from genome-wide association studies of Alzheimer's disease.
Andrews, SJ., et al.
2020,
Neurology. Genetics
Use of local genetic ancestry to assess TOMM40-523' and risk for Alzheimer disease.
Bussies, PL., et al.
2020,
Alzheimer's & dementia : the journal of the Alzheimer's Association
Plasma biomarkers of astrocytic and neuronal dysfunction in early- and late-onset Alzheimer's disease.
Elahi, FM., et al.
2020,
Neuron
Human Herpesvirus 6 Detection in Alzheimer's Disease Cases and Controls across Multiple Cohorts.
Allnutt, MA., et al.
2020,
Translational psychiatry
Shared genetic etiology underlying Alzheimer's disease and major depressive disorder.
Lutz, MW., et al.
2020,
Cerebral cortex (New York, N.Y. : 1991)
Corticosteroids and Regional Variations in Thickness of the Human Cerebral Cortex across the Lifespan.
Parker, N., et al.
2020,
Science (New York, N.Y.)
The genetic architecture of the human cerebral cortex.
Grasby, KL., et al.
2020,
Current opinion in immunology
Innate sensing of mechanical properties of brain tissue by microglia.
Ayata, P.
2020,
Proceedings of the National Academy of Sciences of the United States of America
De novo mutations across 1,465 diverse genomes reveal mutational insights and reductions in the Amish founder population.
Kessler, MD., et al.
2020,
Alzheimer's & dementia : the journal of the Alzheimer's Association
Association between alcohol consumption and Alzheimer's disease: A Mendelian randomization study.
Andrews, SJ., et al.
2020,
Acta neuropathologica
Overlapping genetic architecture between Parkinson disease and melanoma.
Dube, U., et al.
2020,
Nature communications
Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study.
Reiman, EM., et al.
2020,
Science translational medicine
APOE genotype regulates pathology and disease progression in synucleinopathy.
Davis, AA., et al.
2020,
The journals of gerontology. Series A, Biological sciences and medical sciences
Epigenetic Age Acceleration and Cognitive Function in African American Adults in Midlife: The Atherosclerosis Risk in Communities Study.
Bressler, J., et al.
2020,
Annals of clinical and translational neurology
Circulating ceramide ratios and risk of vascular brain aging and dementia.
McGrath, ER., et al.
2020,
Neuropsychology
Linking depressive symptoms and cognitive functioning: The mediating role of leisure activity.
Sharifian, N., et al.
2020,
Genetic epidemiology
Case-control versus case-only estimates of gene-environment interactions with common and misclassified clinical diagnosis.
Lobach, I., et al.
2020,
Alzheimer's & dementia : the journal of the Alzheimer's Association
Two-stage Bayesian GWAS of 9576 individuals identifies SNP regions that are targeted by miRNAs inversely expressed in Alzheimer's and cancer.
Pathak, GA., et al.
2020,
Acta neuropathologica
The TMEM106B FTLD-protective variant, rs1990621, is also associated with increased neuronal proportion.
Li, Z., et al.
2020,
The Lancet. Neurology
Antihypertensive medications and risk for incident dementia and Alzheimer's disease: a meta-analysis of individual participant data from prospective cohort studies.
Ding, J., et al.
2020,
Neurology
Association of CD14 with incident dementia and markers of brain aging and injury.
Pase, MP., et al.
2020,
Journal of neuropathology and experimental neurology
Alzheimer Disease Pathology-Associated Polymorphism in a Complex Variable Number of Tandem Repeat Region Within the MUC6 Gene, Near the AP2A2 Gene.
Katsumata, Y., et al.
2020,
Journal of Alzheimer's disease : JAD
Neurofilament Light Predicts Decline in Attention but Not Episodic Memory in Preclinical Alzheimer's Disease.
Aschenbrenner, AJ., et al.
2020,
The Journal of neuropsychiatry and clinical neurosciences
Effect of Functional BDNF and COMT Polymorphisms on Symptoms and Regional Brain Volume in Frontotemporal Dementia and Corticobasal Syndrome.
Huey, ED., et al.
2020,
Journal of Alzheimer's disease : JAD
CCL23: A Chemokine Associated with Progression from Mild Cognitive Impairment to Alzheimer's Disease.
Faura, J., et al.
2020,
Alzheimer disease and associated disorders
Physical Exercise and Longitudinal Trajectories in Alzheimer Disease Biomarkers and Cognitive Functioning.
Stojanovic, M., et al.
2020,
Alzheimer's & dementia (New York, N. Y.)
Differences in plasma metabolites related to Alzheimer's disease, APOE ε4 status, and ethnicity.
Vardarajan, B., et al.
2020,
Alzheimer's & dementia (Amsterdam, Netherlands)
APOE ε4 and resting-state functional connectivity in racially/ethnically diverse older adults.
Turney, IC., et al.
2020,
Immunity & ageing : I & A
Reproducibility of serum cytokines in an elderly population.
Guo, J., et al.
2020,
Biodemography and social biology
Methodological considerations in designing and implementing the harmonized diagnostic assessment of dementia for longitudinal aging study in India (LASI-DAD).
Banerjee, J., et al.
2020,
Journal of Alzheimer's disease : JAD
Circulating Vitamin D Levels and Alzheimer's Disease: A Mendelian Randomization Study in the IGAP and UK Biobank.
Wang, L., et al.
2020,
Journal of Alzheimer's disease : JAD
Impact of Vitamin D Binding Protein Levels on Alzheimer's Disease: A Mendelian Randomization Study.
Zhang, H., et al.
2020,
Journal of Alzheimer's disease : JAD
Impact of Serum Calcium Levels on Alzheimer's Disease: A Mendelian Randomization Study.
He, Y., et al.
2020,
PloS one
Identification of functionally connected multi-omic biomarkers for Alzheimer's disease using modularity-constrained Lasso.
Xie, L., et al.
2020,
Journal of Alzheimer's disease : JAD
Characterizing Clinical and Neuropathological Traits of APOE Haplotypes in African Americans and Europeans.
Mezlini, AM., et al.
2020,
PloS one
Quantifying cognitive resilience in Alzheimer's Disease: The Alzheimer's Disease Cognitive Resilience Score.
Yao, T., et al.
2020,
Journal of Alzheimer's disease : JAD
Investigating Causal Relations Between Risk Tolerance, Risky Behaviors, and Alzheimer's Disease: A Bidirectional Two-Sample Mendelian Randomization Study.
Yang, Y., et al.
2020,
Frontiers in aging neuroscience
Association of Genes Involved in the Metabolic Pathways of Amyloid-β and Tau Proteins With Sporadic Late-Onset Alzheimer's Disease in the Southern Han Chinese Population.
Xiao, X., et al.
2020,
Frontiers in genetics
Recent Consanguinity and Outbred Autozygosity Are Associated With Increased Risk of Late-Onset Alzheimer's Disease.
Napolioni, V., et al.
2020,
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
Packaging Biocomputing Software to Maximize Distribution and Reuse.
Bush, WS., et al.
2020,
Computational and structural biotechnology journal