Filter by Year:

2023

2023,  
Neurobiology of Aging

Amyloid and tau pathology are associated with cerebral blood flow in a mixed sample of nondemented older adults with and without vascular risk factors for Alzheimer's disease

Swinford, CG., et al.
2023,  
Statistics in Medicine

Deep causal feature extraction and inference with neuroimaging genetic data

Yao, Y., et al.
2023,  
JAMA neurology

Associations of Sex, Race, and Apolipoprotein E Alleles With Multiple Domains of Cognition Among Older Adults

Walters, S., et al.
2023,  
Alzheimer Disease and Associated Disorders

Visuospatial and Verbal Memory Differences in Amish Individuals With Alzheimer Disease and Related Dementias

Prough, MB., et al.
2023,  
Journal of the American Geriatrics Society

Can virtual reality travel help nursing home patients fulfill their bucket list?

Rodriguez, DK.
2023,  
Nature Reviews. Cardiology

The bidirectional association between atrial fibrillation and myocardial infarction

Frederiksen, TC., et al.
2023,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

The Early-Onset Alzheimer's Disease Whole-Genome Sequencing Project: Study design and methodology

Ray, NR., et al.
2023,  
International Journal of Geriatric Psychiatry

Neuropsychiatric features in a multi-ethnic population with Alzheimer disease and mild cognitive impairment

Celis, K., et al.
2023,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Ancestry-related differences in chromatin accessibility and gene expression of APOE ε4 are associated with Alzheimer's disease risk

Celis, K., et al.
2023,  
Cell Reports

Cell-type-specific regulation of APOE and CLU levels in human neurons by the Alzheimer's disease risk gene SORL1

Lee, H., et al.
2023,  
Cell Reports

Poly(GR) interacts with key stress granule factors promoting its assembly into cytoplasmic inclusions

Park, J., et al.
2023,  
Human Molecular Genetics

Integrating GWAS summary statistics, individual-level genotypic and omic data to enhance the performance for large-scale trait imputation

Ren, J., et al.
2023,  
Journal of Neuropathology and Experimental Neurology

LATE-NC risk alleles (in TMEM106B, GRN, and ABCC9 genes) among persons with African ancestry

Katsumata, Y., et al.
2023,  
Nature Communications

Whole genome deconvolution unveils Alzheimer's resilient epigenetic signature

Berson, E., et al.
2023,  
Proceedings of the National Academy of Sciences of the United States of America

The liquid-to-solid transition of FUS is promoted by the condensate surface

Shen, Y., et al.
2023,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

DNA from multiple viral species is associated with Alzheimer's disease risk

Tejeda, M., et al.
2023,  
Genetic Epidemiology

Inference of causal metabolite networks in the presence of invalid instrumental variables with GWAS summary data

Chen, S., et al.
2023,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Transcriptional risk scores in Alzheimer's disease: From pathology to cognition

Pyun, J., et al.
2023,  
Journal of Clinical Medicine

Genetics of Alzheimer's Disease in the African American Population

Logue, MW., et al.
2023,  
Cell Genomics

Multiset correlation and factor analysis enables exploration of multi-omics data

Brown, BC., et al.
2023,  
Biology of Sex Differences

Sex differences in metabolic phenotype and hypothalamic inflammation in the 3xTg-AD mouse model of Alzheimer's disease

Robison, LS., et al.
2023,  
BMJ open

Using community-based geographical information system (GIS) to recruit older Asian Americans in an Alzheimer's disease study

Lee, H., et al.
2023,  
Neuron

An astrocyte BMAL1-BAG3 axis protects against alpha-synuclein and tau pathology

Sheehan, PW., et al.
2023,  
Bioinformatics (Oxford, England)

ShinyBioHEAT: an interactive shiny app to identify phenotype driver genes in E.coli and B.subtilis

Wang, C., et al.
2023,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Genome-wide methylomic regulation of multiscale gene networks in Alzheimer's disease

Wang, E., et al.
2023,  
Journal of the American Geriatrics Society

Nursing home infection control strategies during the COVID-19 pandemic

Festa, N., et al.
2023,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Identification of circRNAs linked to Alzheimer's disease and related dementias

Puri, S., et al.
2023,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Obesity impacts the expression of Alzheimer's disease-related genes: The Framingham Heart Study

Charisis, S., et al.
2023,  
International Journal of Stroke: Official Journal of the International Stroke Society

Pleiotropy analysis between lobar intracerebral hemorrhage and CSF β-amyloid highlights new and established associations

Marini, S., et al.
2023,  
Human Molecular Genetics

Human herpesvirus 8 ORF57 protein is able to reduce TDP-43 pathology: network analysis identifies interacting pathways

Webber, CJ., et al.
2023,  
Proceedings of the National Academy of Sciences of the United States of America

Slingshot homolog-1-mediated Nrf2 sequestration tips the balance from neuroprotection to neurodegeneration in Alzheimer's disease

Cazzaro, S., et al.
2023,  
medRxiv: The Preprint Server for Health Sciences

APOE loss-of-function variants: Compatible with longevity and associated with resistance to Alzheimer's Disease pathology

Chemparathy, A., et al.
2023,  
Journal of Neuropathology and Experimental Neurology

The frequency and distribution of TDP-43 pathology in argyrophilic grain disease

Koga, S., et al.
2023,  
Human Molecular Genetics

Genetic architecture of plasma Alzheimer disease biomarkers

Bradley, J., et al.
2023,  
Science Translational Medicine

Proteomics analysis of plasma from middle-aged adults identifies protein markers of dementia risk in later life

Walker, KA., et al.
2023,  
HGG advances

Using GWAS summary data to impute traits for genotyped individuals

Ren, J., et al.
2023,  
HGG advances

Admixture mapping implicates 13q33.3 as ancestry-of-origin locus for Alzheimer disease in Hispanic and Latino populations

Horimoto, ARVR., et al.
2023,  
Cell Metabolism

When a calorie is not just a calorie: Diet quality and timing as mediators of metabolism and healthy aging

Mihaylova, MM., et al.
2023,  
NPJ Regenerative medicine

Nerve growth factor receptor (Ngfr) induces neurogenic plasticity by suppressing reactive astroglial Lcn2/Slc22a17 signaling in Alzheimer's disease

Siddiqui, T., et al.
2023,  
NPJ Parkinson's disease

Proteome wide association studies of LRRK2 variants identify novel causal and druggable proteins for Parkinson's disease

Phillips, B., et al.
2023,  
Acta Neuropathologica Communications

Diffuse argyrophilic grain disease with TDP-43 proteinopathy and neuronal intermediate filament inclusion disease: FTLD with mixed tau, TDP-43 and FUS pathologies

Koga, S., et al.
2023,  
Science Translational Medicine

Proteomics of brain, CSF, and plasma identifies molecular signatures for distinguishing sporadic and genetic Alzheimer's disease

Sung, YJ., et al.
2023,  
Brain: A Journal of Neurology

Reduced endothelial caveolin-1 underlies deficits in brain insulin signalling in type 2 diabetes

Shetti, AU., et al.
2023,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Long-term blood pressure patterns in midlife and dementia in later life: Findings from the Framingham Heart Study

Kim, H., et al.
2023,  
International Journal of Molecular Sciences

Stealth Liposomes Encapsulating a Potent ACAT1/SOAT1 Inhibitor F12511: Pharmacokinetic, Biodistribution, and Toxicity Studies in Wild-Type Mice and Efficacy Studies in Triple Transgenic Alzheimer's Disease Mice

De La Torre, AL., et al.
2023,  
NeuroImage

Image harmonization: A review of statistical and deep learning methods for removing batch effects and evaluation metrics for effective harmonization

Hu, F., et al.
2023,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Examination of potentially modifiable dementia risk factors across the adult life course: The Framingham Heart Study

Hwang, PH., et al.
2023,  
Behavior Genetics

A Varying Coefficient Model to Jointly Test Genetic and Gene-Environment Interaction Effects

Zhou, Z., et al.
2023,  
Acta Neuropathologica

Brain DNA methylomic analysis of frontotemporal lobar degeneration reveals OTUD4 in shared dysregulated signatures across pathological subtypes

Fodder, K., et al.
2023,  
Circulation. Cardiovascular Quality and Outcomes

Association Between Electrocardiographic Age and Cardiovascular Events in Community Settings: The Framingham Heart Study

Brant, LCC., et al.
2023,  
Nature Human Behaviour

Identifying modifiable factors and their joint effect on dementia risk in the UK Biobank

Zhang, Y., et al.
2023,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Identification of novel genes for age-at-onset of Alzheimer's disease by combining quantitative and survival trait analyses

Li, Y., et al.
2023,  
Otolaryngology--Head and Neck Surgery: Official Journal of American Academy of Otolaryngology-Head and Neck Surgery

Association of Central Auditory Processing Dysfunction With Preclinical Alzheimer's Disease

Byun, MS., et al.
2023,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Prevalence of dementia in India: National and state estimates from a nationwide study

Lee, J., et al.
2023,  
Nature Medicine

Clonal hematopoiesis is associated with protection from Alzheimer's disease

Bouzid, H., et al.
2023,  
Scientific Reports

Modeling of mitochondrial genetic polymorphisms reveals induction of heteroplasmy by pleiotropic disease locus 10398A>G

Smullen, M., et al.
2023,  
Molecular Neurodegeneration

A genome-wide search for pleiotropy in more than 100,000 harmonized longitudinal cognitive domain scores

Kang, M., et al.
2023,  
International Journal of Molecular Sciences

Cholesterol, Amyloid Beta, Fructose, and LPS Influence ROS and ATP Concentrations and the Phagocytic Capacity of HMC3 Human Microglia Cell Line

Muñoz Herrera, OM., et al.
2023,  
Nature Communications

Leveraging football accelerometer data to quantify associations between repetitive head impacts and chronic traumatic encephalopathy in males

Daneshvar, DH., et al.
2023,  
British Journal of Pharmacology

Hydrogen sulfide signalling in neurodegenerative diseases

Tripathi, SJ., et al.
2023,  
The Journal of Clinical Investigation

Complement C3aR depletion reverses HIF-1α-induced metabolic impairment and enhances microglial response to Aβ pathology

Gedam, M., et al.
2023,  
Alzheimer's Research & Therapy

Body mass index and two-year change of in vivo Alzheimer's disease pathologies in cognitively normal older adults

Lee, S., et al.
2023,  
GeroScience

Sexual dimorphic metabolic and cognitive responses of C57BL/6 mice to Fisetin or Dasatinib and quercetin cocktail oral treatment

Fang, Y., et al.
2023,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Profiling and predicting distinct tau progression patterns: An unsupervised data-driven approach to flortaucipir positron emission tomography

Tosun, D., et al.
2023,  
Neurology

The Importance of Understanding Neighborhood Environments in Neurology Care

Kobau, R.
2023,  
Angewandte Chemie (International Ed. in English)

Apolipoprotein E Recognizes Alzheimer's Disease Associated 3-O Sulfation of Heparan Sulfate

Mah, D., et al.
2023,  
The Journal of Cell Biology

Autolysosomal exocytosis of lipids protect neurons from ferroptosis

Ralhan, I., et al.
2023,  
Neurobiology of Disease

Amyloid beta peptides (Aβ) from Alzheimer's disease neuronal secretome induce endothelial activation in a human cerebral microvessel model

Shin, YJ., et al.
2023,  
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

Chronic, Mild Hypothermic Environmental Temperature Does Not Ameliorate Cognitive Deficits in an Alzheimer's Disease Mouse

McFadden, S., et al.
2023,  
Brain: A Journal of Neurology

The pathotome and precision health

Younes, K.
2023,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Novel loci for Alzheimer's disease identified by a genome-wide association study in Ashkenazi Jews

Li, D., et al.
2023,  
Aging and Disease

Serum Adiponectin and In Vivo Brain Amyloid Deposition in Cognitively Normal Older Adults: A Cohort Study

Kim, JW., et al.
2023,  
Telemedicine Journal and E-Health: The Official Journal of the American Telemedicine Association

Decreasing Racial Disparities in Preventable Emergency Department Visits Through Hospital Health Information Technology Patient Engagement Functionalities

Wang, N.
2023,  
Nature Neuroscience

Single-nucleus multiregion transcriptomic analysis of brain vasculature in Alzheimer's disease

Sun, N., et al.
2023,  
GeroScience

Geroprotective interventions in the 3xTg mouse model of Alzheimer's disease

Sonsalla, MM.
2023,  
Journal of the American Geriatrics Society

Factors affecting the recruitment of Hispanic/Latinx American older adults in clinical trials in the United States: A scoping review

Rodriguez, DK., et al.
2023,  
Nature Aging

Targeting the biology of aging with mTOR inhibitors

Mannick, JB.
2023,  
Neurobiology of Aging

Characterization of apathy-like behaviors in the 5xFAD mouse model of Alzheimer's disease

Keszycki, R., et al.
2023,  
The Journal of Physiology

Regulation of metabolic health by dietary histidine in mice

Flores, V., et al.
2023,  
British Journal of Cancer

Evolution of cisplatin resistance through coordinated metabolic reprogramming of the cellular reductive state

Yu, W., et al.
2023,  
Journal of Biomedical Informatics

HLA amino acid Mismatch-Based risk stratification of kidney allograft failure using a novel Machine learning algorithm

Dasariraju, S., et al.
2023,  
Acta Neuropathologica

Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation

Filipello, F., et al.
2023,  
Trends in Neurosciences

Moving beyond amyloid and tau to capture the biological heterogeneity of Alzheimer's disease

Young-Pearse, TL., et al.
2023,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

APOE and immunity: Research highlights

Kloske, CM., et al.
2023,  
Neurobiology of Aging

Multi-omic characterization of brain changes in the vascular endothelial growth factor family during aging and Alzheimer's disease

Seto, M., et al.
2023,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Social enrichment on the job: Complex work with people improves episodic memory, promotes brain reserve, and reduces the risk of dementia

Coleman, ME., et al.
2023,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Admixture mapping identifies novel Alzheimer's disease risk regions in African Americans

Rajabli, F., et al.
2023,  
Journal of Racial and Ethnic Health Disparities

Multiple Chronic Conditions and Disability among Vietnamese Older Adults: Results from the Vietnamese Aging and Care Survey (VACS)

Miyawaki, CE., et al.
2023,  
Science Advances

Increased 3-O-sulfated heparan sulfate in Alzheimer's disease brain is associated with genetic risk gene HS3ST1

Wang, Z., et al.
2023,  
Translational Psychiatry

Circulating S100B levels at birth and risk of six major neuropsychiatric or neurological disorders: a two-sample Mendelian Randomization Study

Pan, M., et al.
2023,  
Cancers

Genetic Variants Associated with Longitudinal Cognitive Performance in Older Breast Cancer Patients and Controls

Nudelman, K., et al.
2023,  
Biology of Sex Differences

Menopause causes metabolic and cognitive impairments in a chronic cerebral hypoperfusion model of vascular contributions to cognitive impairment and dementia

Gannon, OJ., et al.
2023,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Large-scale proteome and metabolome analysis of CSF implicates altered glucose and carbon metabolism and succinylcarnitine in Alzheimer's disease

Panyard, DJ., et al.
2023,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Leveraging African American family connectors for Alzheimer's disease genomic studies

Byfield, G., et al.
2023,  
Biology of Sex Differences

Sex differences in the effects of high fat diet on underlying neuropathology in a mouse model of VCID

Abi-Ghanem, C., et al.
2023,  
Neuropathology: Official Journal of the Japanese Society of Neuropathology

Comments on an autopsy case of progressive supranuclear palsy treated with monoclonal antibody against tau

Koga, S., et al.
2023,  
Scientific Reports

Transcriptomic and glycomic analyses highlight pathway-specific glycosylation alterations unique to Alzheimer's disease

Tang, X., et al.
2023,  
Antioxidants (Basel, Switzerland)

Protective Roles of Hydrogen Sulfide in Alzheimer's Disease and Traumatic Brain Injury

Paul, BD.
2023,  
Nature Communications

Functional variants identify sex-specific genes and pathways in Alzheimer's Disease

Bourquard, T., et al.
2023,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Alzheimer's disease heterogeneity explained by polygenic risk scores derived from brain transcriptomic profiles

Chung, J., et al.
2023,  
Cerebral Cortex (New York, N.Y.: 1991)

Heritability of cognitive abilities and regional brain structures in middle-aged to elderly East Asians

Lee, Y., et al.
2023,  
Cell Stem Cell

Advancing cell therapy for neurodegenerative diseases

Temple, S.
2023,  
Biological Psychiatry

Integrative Co-methylation Network Analysis Identifies Novel DNA Methylation Signatures and Their Target Genes in Alzheimer's Disease

Kim, JP., et al.
2023,  
Nature Reviews. Neurology

A global view of the genetic basis of Alzheimer disease

Reitz, C., et al.
2023,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Metabolomic and lipidomic signatures in autosomal dominant and late-onset Alzheimer's disease brains

Novotny, BC., et al.
2023,  
Glia

The role of FUT8-catalyzed core fucosylation in Alzheimer's amyloid-β oligomer-induced activation of human microglia

Jin, L., et al.
2023,  
Dementia (London, England)

Understanding Capacity and Optimizing Meaningful Engagement among Persons Living with Dementia

Kemp, CL., et al.
2023,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Cost-effectiveness models for Alzheimer's disease and related dementias: IPECAD modeling workshop cross-comparison challenge

Handels, RLH., et al.
2023,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Association of spermidine plasma levels with brain aging in a population-based study

Wortha, SM., et al.
2023,  
Neuropsychology

Harmonizing the preclinical Alzheimer cognitive composite for multicohort studies

Hampton, OL., et al.
2023,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Population-based discovery and Mendelian randomization analysis identify telmisartan as a candidate medicine for Alzheimer's disease in African Americans

Zhang, P., et al.
2023,  
PLoS genetics

Combining Mendelian randomization and network deconvolution for inference of causal networks with GWAS summary data

Lin, Z., et al.
2023,  
Neuropsychology

Cognitive domain harmonization and cocalibration in studies of older adults

Mukherjee, S., et al.
2023,  
Annals of Clinical and Translational Neurology

Polygenic risk score penetrance & recurrence risk in familial Alzheimer disease

Qiao, M., et al.
2023,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Blood levels of MCP-1 modulate the genetic risks of Alzheimer's disease mediated by HLA-DRB1 and APOE for Alzheimer's disease

Huang, J., et al.
2023,  
Experimental & Molecular Medicine

Sex differences in the progression of glucose metabolism dysfunction in Alzheimer's disease

Park, J., et al.
2023,  
Annals of Neurology

Aberrant GAP43 Gene Expression Is Alzheimer Disease Pathology-Specific

Pyun, J., et al.
2023,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Measurement differences in the assessment of functional limitations for cognitive impairment classification across geographic locations

Nichols, E., et al.
2023,  
Acta Neuropathologica Communications

Large multi-ethnic genetic analyses of amyloid imaging identify new genes for Alzheimer disease

Ali, M., et al.
2023,  
Cell Reports

A plasma membrane-associated glycolytic metabolon is functionally coupled to KATP channels in pancreatic α and β cells from humans and mice

Ho, T., et al.
2023,  
iScience

Plasma proteomics of SARS-CoV-2 infection and severity reveals impact on Alzheimer's and coronary disease pathways

Wang, L., et al.
2023,  
Nature Communications

Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers

Brase, L., et al.
2023,  
The World Journal of Men's Health

Responses to Many Anti-Aging Interventions Are Sexually Dimorphic

Bartke, A., et al.
2023,  
Alzheimer's Research & Therapy

Higher performance for women than men in MRI-based Alzheimer's disease detection

Klingenberg, M., et al.
2023,  
Science Translational Medicine

Lateral mammillary body neurons in mouse brain are disproportionately vulnerable in Alzheimer's disease

Huang, W., et al.
2023,  
Brain: A Journal of Neurology

Brain functional connectivity mirrors genetic pleiotropy in psychiatric conditions

Moreau, CA., et al.
2023,  
Genes

Interaction between KLOTHO-VS Heterozygosity and APOE ε4 Allele Predicts Rate of Cognitive Decline in Late-Onset Alzheimer's Disease

Chen, XR., et al.
2023,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

A haptoglobin (HP) structural variant alters the effect of APOE alleles on Alzheimer's disease

Bai, H., et al.
2023,  
Scientific Reports

Sex-specific differences in the genetic and environmental effects on cardiac phenotypic variation assessed by echocardiography

Lin, H., et al.
2023,  
Human Molecular Genetics

MATS: a novel multi-ancestry transcriptome-wide association study to account for heterogeneity in the effects of cis-regulated gene expression on complex traits

Knutson, KA.
2023,  
American Journal of Human Genetics

Robust multivariable Mendelian randomization based on constrained maximum likelihood

Lin, Z., et al.
2023,  
American Journal of Human Genetics

Evidence of epistasis in regions of long-range linkage disequilibrium across five complex diseases in the UK Biobank and eMERGE datasets

Singhal, P., et al.
2023,  
Annals of Behavioral Medicine: A Publication of the Society of Behavioral Medicine

An Examination of the Longitudinal Relationship Between Cognitive Function and Physical Activity Among Older Breast Cancer Survivors in the Thinking and Living With Cancer Study

Tometich, DB., et al.
2023,  
JAMA network open

Assessment of Risk Factors and Clinical Importance of Enlarged Perivascular Spaces by Whole-Brain Investigation in the Multi-Ethnic Study of Atherosclerosis

Charisis, S., et al.
2023,  
JAMA network open

Evaluation of Plasma Biomarkers for A/T/N Classification of Alzheimer Disease Among Adults of Caribbean Hispanic Ethnicity

Honig, LS., et al.
2023,  
American Journal of Physiology. Cell Physiology

Heparan sulfate proteoglycan in Alzheimer's disease: aberrant expression and functions in molecular pathways related to amyloid-β metabolism

Ozsan McMillan, I., et al.
2023,  
NeuroImage

Deep neural network heatmaps capture Alzheimer's disease patterns reported in a large meta-analysis of neuroimaging studies

Wang, D., et al.
2023,  
NeuroImage

Multiscale functional connectivity patterns of the aging brain learned from harmonized rsfMRI data of the multi-cohort iSTAGING study

Zhou, Z., et al.
2023,  
NeuroImage

Applications of generative adversarial networks in neuroimaging and clinical neuroscience

Wang, R., et al.
2023,  
EBioMedicine

The complex genetic architecture of Alzheimer's disease: novel insights and future directions

Andrews, SJ., et al.
2023,  
Nature Genetics

Adjusting for common variant polygenic scores improves yield in rare variant association analyses

Jurgens, SJ., et al.
2023,  
Nature Medicine

Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease

Duperron, M., et al.
2023,  
Neurobiology of Aging

Neural atrophy produced by AAV tau injections into hippocampus and anterior cortex of middle-aged mice

Tetlow, AM., et al.
2023,  
eNeuro

Amyloid β-Peptide Effects on Glucose Regulation Are Dependent on Apolipoprotein E Genotype

Sung, JH., et al.
2023,  
AJNR. American journal of neuroradiology

Incidental Findings from 16,400 Brain MRI Examinations of Research Volunteers

Rowley, PA., et al.
2023,  
Acta Neuropathologica

Chronic traumatic encephalopathy (CTE): criteria for neuropathological diagnosis and relationship to repetitive head impacts

McKee, AC., et al.
2023,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Comorbidity-driven multi-modal subtype analysis in mild cognitive impairment of Alzheimer's disease

Katabathula, S., et al.
2023,  
Journal of the American Geriatrics Society

Reappraising the public health benefits conferred by environmental policy: Considerations for an aging society

Festa, N., et al.
2023,  
GeroScience

Resistance to mild cold stress is greater in both wild-type and long-lived GHR-KO female mice

Fang, Y., et al.
2023,  
GeroScience

Urolithin A reduces amyloid-beta load and improves cognitive deficits uncorrelated with plaque burden in a mouse model of Alzheimer's disease

Ballesteros-Álvarez, J., et al.
2023,  
The Journal of Biological Chemistry

Coevolutionary signals in metabotropic glutamate receptors capture residue contacts and long-range functional interactions

Huh, E., et al.
2023,  
Neurobiology of Disease

The role of innate lymphocytes in regulating brain and cognitive function

Si, Y., et al.
2023,  
Psychiatry and Clinical Neurosciences

Circadian rest-activity rhythm and longitudinal brain changes underlying late-life cognitive decline

Jeon, SY., et al.
2023,  
Brain Imaging and Behavior

Altered cerebral blood flow in older adults with Alzheimer's disease: a systematic review

Swinford, CG., et al.
2023,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Differential diagnosis of amnestic dementia patients based on an FDG-PET signature of autopsy-confirmed LATE-NC

Grothe, MJ., et al.
2023,  
International Journal of Geriatric Psychiatry

Psychometric approaches to defining cognitive phenotypes in the Old Order Amish

Zaman, A., et al.
2023,  
Alzheimer's Research & Therapy

Alzheimer's disease genetic risk and cognitive reserve in relationship to long-term cognitive trajectories among cognitively normal individuals

Pettigrew, C., et al.
2023,  
JMIR public health and surveillance

The Effect of Activity Participation in Middle-Aged and Older People on the Trajectory of Depression in Later Life: National Cohort Study

Gao, Y., et al.
2023,  
International Journal of Molecular Sciences

Co-Expression Network Analysis Identifies Molecular Determinants of Loneliness Associated with Neuropsychiatric and Neurodegenerative Diseases

Santiago, JA., et al.
2023,  
Briefings in Bioinformatics

Integrative analysis of multi-omics and imaging data with incorporation of biological information via structural Bayesian factor analysis

Bao, J., et al.
2023,  
Alzheimer's Research & Therapy

The relationship of insulin resistance and diabetes to tau PET SUVR in middle-aged to older adults

Ennis, GE., et al.
2023,  
International Journal of Molecular Sciences

Integrin β3-Mediated Cell Senescence Associates with Gut Inflammation and Intestinal Degeneration in Models of Alzheimer's Disease

Tun, X., et al.
2023,  
International Journal of Molecular Sciences

ACAT1/SOAT1 Blockade Suppresses LPS-Mediated Neuroinflammation by Modulating the Fate of Toll-like Receptor 4 in Microglia

Li, H., et al.
2023,  
Neuron

Evolutionarily conserved regulators of tau identify targets for new therapies

Kim, J., et al.
2023,  
International Journal of Molecular Sciences

Acute ACAT1/SOAT1 Blockade Increases MAM Cholesterol and Strengthens ER-Mitochondria Connectivity

Harned, TC., et al.
2023,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

The Nairobi Declaration-Reducing the burden of dementia in low- and middle-income countries (LMICs): Declaration of the 2022 Symposium on Dementia and Brain Aging in LMICs

Maestre, G., et al.
2023,  
Journal of Medical Internet Research

Step Count, Self-reported Physical Activity, and Predicted 5-Year Risk of Atrial Fibrillation: Cross-sectional Analysis

Shapira-Daniels, A., et al.
2023,  
JAMA network open

Association of Intensive vs Standard Blood Pressure Control With Regional Changes in Cerebral Small Vessel Disease Biomarkers: Post Hoc Secondary Analysis of the SPRINT MIND Randomized Clinical Trial

Rashid, T., et al.
2023,  
Genes

Deep Learning-Based Feature Extraction with MRI Data in Neuroimaging Genetics for Alzheimer's Disease

Chakraborty, D., et al.
2023,  
Molecular Psychiatry

African ancestry GWAS of dementia in a large military cohort identifies significant risk loci

Sherva, R., et al.
2023,  
Nature Aging

Human striatal glia differentially contribute to AD- and PD-specific neurodegeneration

Xu, J., et al.
2023,  
Annals of Neurology

Alzheimer's Disease Genetic Risk, Cognition, and Brain Aging in Midlife

Brenowitz, WD., et al.
2023,  
Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine

Evaluation of Tau Radiotracers in Chronic Traumatic Encephalopathy

Varlow, C.
2023,  
Cell Research

mTOR gets greasy: lysosomal sensing of cholesterol

Bar-Peled, L.
2023,  
Neuroimage. Reports

Deep Learning Based Detection of Enlarged Perivascular Spaces on Brain MRI

Rashid, T., et al.
2023,  
Trends in Neurosciences

The foundation and architecture of precision medicine in neurology and psychiatry

Hampel, H., et al.
2023,  
JAMA

Association of African Ancestry-Specific APOE Missense Variant R145C With Risk of Alzheimer Disease

Le Guen, Y., et al.
2023,  
Genome Biology

FixItFelix: improving genomic analysis by fixing reference errors

Behera, S., et al.
2023,  
Genome Medicine

TREM2 splice isoforms generate soluble TREM2 species that disrupt long-term potentiation

Moutinho, M., et al.
2023,  
Human Brain Mapping

Benchmarking the generalizability of brain age models: Challenges posed by scanner variance and prediction bias

Jirsaraie, RJ., et al.
2023,  
BMC public health

Cohort Profile: Real-Time Insights of COVID-19 in India (RTI COVID-India)

Banerjee, J., et al.
2023,  
Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology: Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology

Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation: the 8th AFNET/EHRA consensus conference

Schnabel, RB., et al.
2023,  
Proceedings of the National Academy of Sciences of the United States of America

Bias in machine learning models can be significantly mitigated by careful training: Evidence from neuroimaging studies

Wang, R., et al.
2023,  
Scientific Reports

In silico analysis of TUBA4A mutations in Amyotrophic Lateral Sclerosis to define mechanisms of microtubule disintegration

Ganne, A., et al.
2023,  
Nature Communications

Alternative polyadenylation transcriptome-wide association study identifies APA-linked susceptibility genes in brain disorders

Cui, Y., et al.
2023,  
Bioinformatics (Oxford, England)

LDmat: efficiently queryable compression of linkage disequilibrium matrices

Weiner, RJ., et al.
2023,  
Science Advances

Chaperoning of specific tau structure by immunophilin FKBP12 regulates the neuronal resilience to extracellular stress

Jiang, L., et al.
2023,  
CNS neuroscience & therapeutics

Enlarged perivascular spaces are associated with decreased brain tau deposition

Kang, KM., et al.
2023,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Genetic variants in the SHISA6 gene are associated with delayed cognitive impairment in two family datasets

Ramos, J., et al.
2023,  
Neurobiology of Aging

Investigation of the independent role of a rare APOE variant (L28P; APOE*4Pittsburgh) in late-onset Alzheimer disease

Fan, K., et al.
2023,  
Molecular Psychiatry

Neuroimmune transcriptome changes in patient brains of psychiatric and neurological disorders

Chen, Y., et al.
2023,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Higher Dietary Inflammatory Index scores are associated with brain MRI markers of brain aging: Results from the Framingham Heart Study Offspring cohort

Melo Van Lent, D., et al.
2023,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

COVID-19 breakthrough infections and hospitalizations among vaccinated patients with dementia in the United States between December 2020 and August 2021

Wang, L., et al.
2023,  
Molecular Psychiatry

Association of COVID-19 with endocarditis in patients with cocaine or opioid use disorders in the US

Wang, L., et al.
2023,  
Journal of Pain and Symptom Management

Patient-Reported Quality Measures for Palliative Care: The Time is now

Walling, AM., et al.
2023,  
American Journal of Public Health

Revisiting Patient Engagement and Empowerment Within the NIMHD Health Disparity Framework

Spencer, MRT.
2023,  
The American Journal of Clinical Nutrition

Human fasting modulates macrophage function and upregulates multiple bioactive metabolites that extend lifespan in Caenorhabditis elegans: a pilot clinical study

Rhodes, CH., et al.
2023,  
Clinics in Geriatric Medicine

Vascular and Nonvascular Mechanisms of Cognitive Impairment and Dementia

Kara, B., et al.
2023,  
IEEE transactions on medical imaging

BrainGB: A Benchmark for Brain Network Analysis With Graph Neural Networks

Cui, H., et al.
2023,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

The small HDL particle hypothesis of Alzheimer's disease

Martinez, AE., et al.
2023,  
Human Molecular Genetics

Integration of transcriptome-wide association study with neuronal dysfunction assays provides functional genomics evidence for Parkinson's disease genes

Li, J., et al.
2023,  
Annual Review of Pathology

Genetics and Pathogenesis of Parkinson's Syndrome

Ye, H., et al.
2023,  
BMC psychiatry

AI-based dimensional neuroimaging system for characterizing heterogeneity in brain structure and function in major depressive disorder: COORDINATE-MDD consortium design and rationale

Fu, CHY., et al.
2023,  
Journal of Medical Internet Research

Increasing Engagement in the Electronic Framingham Heart Study: Factorial Randomized Controlled Trial

Trinquart, L., et al.
2023,  
Scientific Data

Deep phenotyping and genomic data from a nationally representative study on dementia in India

Lee, J., et al.
2023,  
Neuron

TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4

Gratuze, M., et al.
2023,  
Alzheimer's Research & Therapy

A novel human tau knock-in mouse model reveals interaction of Abeta and human tau under progressing cerebral amyloidosis in 5xFAD mice

Barendrecht, S., et al.
2023,  
Neurology

Determinants of Perivascular Spaces in the General Population: A Pooled Cohort Analysis of Individual Participant Data

Evans, TE., et al.
2023,  
Proceedings of the National Academy of Sciences of the United States of America

Anatomically interpretable deep learning of brain age captures domain-specific cognitive impairment

Yin, C., et al.
2023,  
Scientific Reports

Explainable machine learning aggregates polygenic risk scores and electronic health records for Alzheimer's disease prediction

Gao, XR., et al.
2023,  
Molecular Neurodegeneration

Genome-wide association study of brain biochemical phenotypes reveals distinct genetic architecture of Alzheimer's disease related proteins

Oatman, SR., et al.
2023,  
Cell

Strength in diversity: Intra-cellular metabolite sharing enhances longevity

Lamming, DW.
2023,  
Biostatistics (Oxford, England)

DeLIVR: a deep learning approach to IV regression for testing nonlinear causal effects in transcriptome-wide association studies

He, R., et al.
2023,  
Medical Care

Hospital-based Health Information Technology Infrastructure: Evidence of Reduced Medicare Payments and Racial Disparities Among Patients With ADRD

Chen, J., et al.
2023,  
Neurobiology of Disease

The Caribbean-Hispanic Alzheimer's disease brain transcriptome reveals ancestry-specific disease mechanisms

Felsky, D., et al.
2023,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Identification of the Aβ37/42 peptide ratio in CSF as an improved Aβ biomarker for Alzheimer's disease

Liu, L., et al.
2023,  
Brain Research Bulletin

Posttranscriptional regulation of neurofilament proteins and tau in health and disease

Yuan, A.
2023,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Increasing participant diversity in AD research: Plans for digital screening, blood testing, and a community-engaged approach in the Alzheimer's Disease Neuroimaging Initiative 4

Weiner, MW., et al.
2023,  
Journal of Palliative Medicine

Revelations from a Machine Learning Analysis of the Most Downloaded Articles Published in Journal of Palliative Medicine 1999-2018

Tamang, S., et al.
2023,  
Journal of Palliative Medicine

Palliative Care Is Proven

Periyakoil, VS.
2023,  
Peptide Science (Hoboken, N.J.)

Current Peptide Vaccine and Immunotherapy Approaches Against Alzheimer's Disease

Parrocha, CMT.
2023,  
Microcirculation (New York, N.Y.: 1994)

KIR channel regulation of electrical conduction along cerebrovascular endothelium: Enhanced modulation during Alzheimer's disease

Hakim, MA.
2023,  
Radiology

Gadolinium Deposition in the Rat Brain Measured with Quantitative MRI versus Elemental Mass Spectrometry

Hua, N., et al.
2023,  
Nature Biotechnology

A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets

Zhou, Y., et al.
2023,  
PLoS genetics

Using epigenomics to understand cellular responses to environmental influences in diseases

Wattacheril, JJ., et al.
2023,  
Nature Neuroscience

Integrative transcriptomic analysis of the amyotrophic lateral sclerosis spinal cord implicates glial activation and suggests new risk genes

Humphrey, J., et al.
2023,  
Medical Image Analysis

Signed graph representation learning for functional-to-structural brain network mapping

Tang, H., et al.
2023,  
Journal of Alzheimer's disease: JAD

Polygenic Liability to Alzheimer's Disease Is Associated with a Wide Range of Chronic Diseases: A Cohort Study of 312,305 Participants

Wu, B., et al.
2023,  
Methods in Molecular Biology (Clifton, N.J.)

Human-Induced Pluripotent Stem Cell (hiPSC)-Derived Neurons and Glia for the Elucidation of Pathogenic Mechanisms in Alzheimer's Disease

Young, JE.
2023,  
The Journal of Cardiovascular Aging

Protein homeostasis in the aged and diseased heart

Mainali, N., et al.
2023,  
Journal of Alzheimer's disease: JAD

Wisconsin Healthcare Utilization Cost Among American Indians/Alaska Natives with and without Alzheimer's Disease and Related Dementias

Johnson, AL., et al.
2023,  
Journal of Alzheimer's disease: JAD

Prodromal Glutamatergic Modulation with Riluzole Impacts Glucose Homeostasis and Spatial Cognition in Alzheimer's Disease Mice

Findley, CA., et al.
2023,  
Frontiers in Aging Neuroscience

Health disparities in aging: Improving dementia care for Black women

Findley, CA., et al.
2023,  
Brain Communications

Associations between self-reported sleep patterns and health, cognition and amyloid measures: results from the Wisconsin Registry for Alzheimer's Prevention

Du, L., et al.
2023,  
The Journal of Prevention of Alzheimer's Disease

Understanding Online Registry Facilitators and Barriers Experienced by Black Brain Health Registry Participants: The Community Engaged Digital Alzheimer's Research (CEDAR) Study

Ashford, MT., et al.
2023,  
Alzheimer's & Dementia (New York, N. Y.)

Alzheimer's disease drug development pipeline: 2023

Cummings, J., et al.
2023,  
Frontiers in Cardiovascular Medicine

Association of lifestyle with deep learning predicted electrocardiographic age

Zhang, C., et al.
2023,  
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing

Polygenic resilience score may be sensitive to preclinical Alzheimer's disease changes

Eissman, JM., et al.
2023,  
Journal of Alzheimer's disease: JAD

A Surface-Based Federated Chow Test Model for Integrating APOE Status, Tau Deposition Measure, and Hippocampal Surface Morphometry

Wu, J., et al.
2023,  
AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science

Exploring Automated Machine Learning for Cognitive Outcome Prediction from Multimodal Brain Imaging using STREAMLINE

Wang, X., et al.
2023,  
AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science

Comparing Amyloid Imaging Normalization Strategies for Alzheimer's Disease Classification using an Automated Machine Learning Pipeline

Tong, B., et al.
2023,  
Frontiers in Molecular Biosciences

Conserved gene signatures shared among MAPT mutations reveal defects in calcium signaling

Minaya, MA., et al.
2023,  
Neuroendocrinology

Changes in Corticotropin-Releasing Factor Receptor Type 1, Co-Expression with Tyrosine Hydroxylase and Oxytocin Neurons, and Anxiety-Like Behaviors across the Postpartum Period in Mice

De Guzman, RM., et al.
2023,  
Clinical Gerontologist

A scoping review of dementia caregiving for Korean Americans and recommendations for future research

Ta Park, VM., et al.
2023,  
Journal of Alzheimer's disease: JAD

Low Ankle-Brachial Index Relates to Alzheimer-Signature Cerebral Glucose Metabolism in Cognitively Impaired Older Adults

Moon, SW., et al.
2023,  
Neuroepidemiology

Estimating the Prevalence of Dementia in India Using a Semi-Supervised Machine Learning Approach

Jin, H., et al.
2023,  
Journal of Sleep Disorders & Therapy

Strategies to Engage Blacks in Sleep Medicine: Lessons Learned from Three Studies Applying Community-Based Participatory Research Principles

Rogers, A., et al.

2022

2022,  
NPJ digital medicine

Factors associated with long-term use of digital devices in the electronic Framingham Heart Study

Pathiravasan, CH., et al.
2022,  
Alzheimer's Research & Therapy

Synergistic interaction of high blood pressure and cerebral beta-amyloid on tau pathology

Kim, T., et al.
2022,  
Journal of Medical Internet Research

Association Between Acoustic Features and Neuropsychological Test Performance in the Framingham Heart Study: Observational Study

Ding, H., et al.
2022,  
Translational Psychiatry

The impact of increasing levels of blood C-reactive protein on the inflammatory loci SPI1 and CD33 in Alzheimer's disease

Huang, J., et al.
2022,  
Brain: A Journal of Neurology

Accelerated longitudinal changes and ordering of Alzheimer disease biomarkers across the adult lifespan

Luo, J., et al.
2022,  
Genome Medicine

Mendelian randomization and genetic colocalization infer the effects of the multi-tissue proteome on 211 complex disease-related phenotypes

Yang, C., et al.
2022,  
International Journal of Molecular Sciences

Physiological Consequences of Targeting 14-3-3 and Its Interacting Partners in Neurodegenerative Diseases

Ganne, A., et al.
2022,  
Cells

Dual-Specificity Protein Phosphatase 4 (DUSP4) Overexpression Improves Learning Behavior Selectively in Female 5xFAD Mice, and Reduces β-Amyloid Load in Males and Females

Pan, AL., et al.
2022,  
Biomedicines

Microglia and Cholesterol Handling: Implications for Alzheimer's Disease

Muñoz Herrera, OM.
2022,  
JAMA network open

Development and Validation of a Prediction Model for Need for Massive Transfusion During Surgery Using Intraoperative Hemodynamic Monitoring Data

Lee, SM., et al.
2022,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Progranulin mutations in clinical and neuropathological Alzheimer's disease

Vardarajan, BN., et al.
2022,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Neuropathological lesions and their contribution to dementia and cognitive impairment in a heterogeneous clinical population

Godrich, D., et al.
2022,  
Nature

Medin co-aggregates with vascular amyloid-β in Alzheimer's disease

Wagner, J., et al.
2022,  
European journal of human genetics: EJHG

Exploiting family history in aggregation unit-based genetic association tests

Wang, Y., et al.
2022,  
Molecular & cellular proteomics: MCP

Glycoproteomics Landscape of Asymptomatic and Symptomatic Human Alzheimer's Disease Brain

Suttapitugsakul, S., et al.
2022,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Synaptic density and cognitive performance in Alzheimer's disease: A PET imaging study with [11 C]UCB-J

Mecca, AP., et al.
2022,  
Aging Cell

SIRT3 deficiency decreases oxidative metabolism capacity but increases lifespan in male mice under caloric restriction

Dhillon, RS., et al.
2022,  
Population Health Management

Strengthening the Public Health Partnership and Telehealth Infrastructure to Reduce Health Care Disparities

Chen, J., et al.
2022,  
Genetic Epidemiology

Statistical power of transcriptome-wide association studies

He, R., et al.
2022,  
Journal of Computational Biology: A Journal of Computational Molecular Cell Biology

Multimodal Genotype and Phenotype Data Integration to Improve Partial Data-Based Longitudinal Prediction

Ganjdanesh, A., et al.
2022,  
Proceedings. IEEE International Conference on Bioinformatics and Biomedicine

Consistency of Graph Theoretical Measurements of Alzheimer's Disease Fiber Density Connectomes Across Multiple Parcellation Scales

Xu, F., et al.
2022,  
Genetic Epidemiology

Genetic heterogeneity: Challenges, impacts, and methods through an associative lens

Woodward, AA., et al.
2022,  
Proceedings. IEEE International Conference on Bioinformatics and Biomedicine

Preference Matrix Guided Sparse Canonical Correlation Analysis for Genetic Study of Quantitative Traits in Alzheimer's Disease

Sha, J., et al.
2022,  
Proceedings. IEEE International Conference on Bioinformatics and Biomedicine

Mediation Analysis and Mixed-Effects Models for the Identification of Stage-specific Imaging Genetics Patterns in Alzheimer's Disease

Pala, D., et al.
2022,  
Nature Genetics

Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's disease

Holstege, H., et al.
2022,  
Biomolecules

Heparan Sulfate Proteoglycans in Tauopathy

Zhu, Y., et al.
2022,  
Cell Reports

Interpretable deep learning translation of GWAS and multi-omics findings to identify pathobiology and drug repurposing in Alzheimer's disease

Xu, J., et al.
2022,  
Science Advances

Generative and reproducible benchmarks for comprehensive evaluation of machine learning classifiers

Orzechowski, P.
2022,  
Scientific Reports

The association between eicosanoids and incident atrial fibrillation in the Framingham Heart Study

Kornej, J., et al.
2022,  
Journal of Neuroinflammation

Neuroimmune proteins can differentiate between tauopathies

Cherry, JD., et al.
2022,  
Briefings in Bioinformatics

Integrating multi-omics summary data using a Mendelian randomization framework

Jin, C., et al.
2022,  
Genome Medicine

Towards elucidating disease-relevant states of neurons and glia by CRISPR-based functional genomics

Leng, K.
2022,  
Cells

Intranasal Peptide Therapeutics: A Promising Avenue for Overcoming the Challenges of Traditional CNS Drug Development

Bose, M., et al.
2022,  
JAMA

Development of a Prediction Model for Ascending Aortic Diameter Among Asymptomatic Individuals

Pirruccello, JP., et al.
2022,  
IEEE transactions on neural networks and learning systems

Contrastive Brain Network Learning via Hierarchical Signed Graph Pooling Model

Tang, H., et al.
2022,  
Cerebral Cortex (New York, N.Y.: 1991)

Co-expression network analysis of frontal cortex during the progression of Alzheimer's disease

Beck, JS., et al.
2022,  
Cell Reports

Loss of neuronal Tet2 enhances hippocampal-dependent cognitive function

Pratt, KJB., et al.
2022,  
NPJ digital medicine

Multimodal machine learning in precision health: A scoping review

Kline, A., et al.
2022,  
Toxins

Omics Methods in Toxins Research-A Toolkit to Drive the Future of Scientific Inquiry

Romano, JD.
2022,  
Neuron

Microglial efferocytosis: Diving into the Alzheimer's disease gene pool

Romero-Molina, C., et al.
2022,  
Nature

APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes

Blanchard, JW., et al.
2022,  
Journal of Geriatric Psychiatry and Neurology

Towards Defining the Neuroanatomical Basis of Late-Onset Psychiatric Symptoms

Barker, MS., et al.
2022,  
Acta Neuropathologica

Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers

Jansen, IE., et al.
2022,  
Nature

Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid

Drieu, A., et al.
2022,  
Medical Care

Identifying Medicare Beneficiaries With Delirium

Moura, LMVR., et al.
2022,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Protein phosphatase 2A and complement component 4 are linked to the protective effect of APOE ɛ2 for Alzheimer's disease

Jun, GR., et al.
2022,  
Neurobiology of Disease

Multiple gene variants linked to Alzheimer's-type clinical dementia via GWAS are also associated with non-Alzheimer's neuropathologic entities

Katsumata, Y., et al.
2022,  
Journal of Psychiatric Research

Association of autoimmune diseases with Alzheimer's disease: A mendelian randomization study

Yeung, CHC., et al.
2022,  
Molecular Psychiatry

Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning

Lahti, J., et al.
2022,  
Molecular & cellular proteomics: MCP

Regio-Specific N-Glycome and N-Glycoproteome Map of the Elderly Human Brain With and Without Alzheimer's Disease

Tena, J., et al.
2022,  
Autophagy

Autolysosomal acidification failure as a primary driver of Alzheimer disease pathogenesis

Lee, J.
2022,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Crosswalk between the Mini-Mental State Examination and the Telephone Interview for Cognitive Status (TICS-27/30/40)

Hlávka, JP., et al.
2022,  
Proceedings of the National Academy of Sciences of the United States of America

Understanding the roles of central and autonomic activity during sleep in the improvement of working memory and episodic memory

Chen, P., et al.
2022,  
The American Journal of Geriatric Psychiatry: Official Journal of the American Association for Geriatric Psychiatry

An HIT-Supported Care Coordination Framework for Reducing Structural Racism and Discrimination for Patients With ADRD

Chen, J., et al.
2022,  
EClinicalMedicine

Different loneliness types, cognitive function, and brain structure in midlife: Findings from the Framingham Heart Study

Tao, Q., et al.
2022,  
Acta Neuropathologica Communications

Artificial intelligence-derived neurofibrillary tangle burden is associated with antemortem cognitive impairment

Marx, GA., et al.
2022,  
Translational Neurodegeneration

Myelin repair in Alzheimer's disease: a review of biological pathways and potential therapeutics

Hirschfeld, LR., et al.
2022,  
Molecular Neurodegeneration

The Golgi apparatus: Site for convergence of COVID-19 brain fog and Alzheimer's disease?

Wang, Y.
2022,  
Nature Communications

Single cell transcriptomic profiling of a neuron-astrocyte assembloid tauopathy model

Rickner, HD., et al.
2022,  
Human Molecular Genetics

Human Molecular Genetics Review Issue 2022

Cheng, F.
2022,  
Human Molecular Genetics

Quantitative trait locus (xQTL) approaches identify risk genes and drug targets from human non-coding genomes

Bykova, M., et al.
2022,  
Biochemistry

Ganglioside-Enriched Phospholipid Vesicles Induce Cooperative Aβ Oligomerization and Membrane Disruption

Saha, J., et al.
2022,  
Cell Reports. Medicine

Transcriptomics-based network medicine approach identifies metformin as a repurposable drug for atrial fibrillation

Lal, JC., et al.
2022,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Metabolomic and lipidomic signatures in autosomal dominant and late-onset Alzheimer's disease brains

Novotny, BC., et al.
2022,  
Nature Communications

Spatial snapshots of amyloid precursor protein intramembrane processing via early endosome proteomics

Park, H., et al.
2022,  
Nature Communications

Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis

Boland, S., et al.
2022,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Whole genome sequencing-based copy number variations reveal novel pathways and targets in Alzheimer's disease

Ming, C., et al.
2022,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

The National Institute on Aging Late-Onset Alzheimer's Disease Family Based Study: A resource for genetic discovery

Reyes-Dumeyer, D., et al.
2022,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Identifying differential regulatory control of APOE ɛ4 on African versus European haplotypes as potential therapeutic targets

Nuytemans, K., et al.
2022,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Integration of GWAS and brain transcriptomic analyses in a multiethnic sample of 35,245 older adults identifies DCDC2 gene as predictor of episodic memory maintenance

Gao, Y., et al.
2022,  
Movement Disorders: Official Journal of the Movement Disorder Society

Common Variants Near ZIC1 and ZIC4 in Autopsy-Confirmed Multiple System Atrophy

Hopfner, F., et al.
2022,  
Molecular Psychiatry

Cognitive performance protects against Alzheimer's disease independently of educational attainment and intelligence

Hu, Y., et al.
2022,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Mendelian randomization highlights causal association between genetically increased C-reactive protein levels and reduced Alzheimer's disease risk

Hu, Y., et al.
2022,  
Nature Biotechnology

DIALOGUE maps multicellular programs in tissue from single-cell or spatial transcriptomics data

Jerby-Arnon, L.
2022,  
Neurobiology of Aging

RNASE6 is a novel modifier of APOE-ε4 effects on cognition

Seto, M., et al.
2022,  
Preventive Medicine

Rural and urban disparities in potentially preventable hospitalizations among US patients with Alzheimer's Disease and Related Dementias: Evidence of hospital-based telehealth and enabling services

Wang, N., et al.
2022,  
Acta Neuropathologica

Rainwater Charitable Foundation criteria for the neuropathologic diagnosis of progressive supranuclear palsy

Roemer, SF., et al.
2022,  
Journal of Palliative Medicine

Symptom Control Research

Periyakoil, VS., et al.
2022,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Moving beyond disclosure: Stages of care in preclinical Alzheimer's disease biomarker testing

Ketchum, FB., et al.
2022,  
Current Opinion in Physiology

Mechanisms Controlling Selective Elimination of Damaged Lysosomes

Hoyer, MJ., et al.
2022,  
Epilepsy Research

A replicable, open-source, data integration method to support national practice-based research & quality improvement systems

Fernandes, M., et al.
2022,  
PLoS computational biology

Deep mendelian randomization: Investigating the causal knowledge of genomic deep learning models

Malina, S., et al.
2022,  
Human Genetics

Genome interpretation using in silico predictors of variant impact

Katsonis, P., et al.
2022,  
Computer Science & Information Technology

Tensor-Based Multi-Modality Feature Selection and Regression for Alzheimer's Disease Diagnosis

Yu, J., et al.
2022,  
Genome Research

Mosaic loss of Chromosome Y in aged human microglia

Vermeulen, MC., et al.
2022,  
Psychiatry and Clinical Neurosciences

Spouse bereavement and brain pathologies: A propensity score matching study

Kim, JW., et al.
2022,  
Neurology. Genetics

A Fast and Robust Strategy to Remove Variant-Level Artifacts in Alzheimer Disease Sequencing Project Data

Belloy, ME., et al.
2022,  
Nature

Stroke genetics informs drug discovery and risk prediction across ancestries

Mishra, A., et al.
2022,  
BMC bioinformatics

Deep multiview learning to identify imaging-driven subtypes in mild cognitive impairment

Feng, Y., et al.
2022,  
Human Molecular Genetics

Genotype-phenotype correlation of T-cell subtypes reveals senescent and cytotoxic genes in Alzheimer's disease

Dressman, D., et al.
2022,  
BMC bioinformatics

Identifying genes associated with brain volumetric differences through tissue specific transcriptomic inference from GWAS summary data

Mai, H., et al.
2022,  
Scientific Reports

Molecular pathways enhance drug response prediction using transfer learning from cell lines to tumors and patient-derived xenografts

Tang, Y., et al.
2022,  
Neurogenetics

Whole-exome sequencing reveals PSEN1 and ATP7B combined variants as a possible cause of early-onset Lewy body dementia: a case study of genotype-phenotype correlation

Tábuas-Pereira, M., et al.
2022,  
Alzheimer's Research & Therapy

Distinct sex-specific DNA methylation differences in Alzheimer's disease

C Silva, T., et al.
2022,  
Human Genetics

The promise of automated machine learning for the genetic analysis of complex traits

Manduchi, E., et al.
2022,  
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

Association Between Mediterranean Diet and Functional Status in Older Adults: A Longitudinal Study Based on the Washington Heights-Inwood Columbia Aging Project

Guo, J., et al.
2022,  
Trends in genetics: TIG

'Fly-ing' from rare to common neurodegenerative disease mechanisms

Ma, M., et al.
2022,  
Neurobiology of Aging

Amyloid, cerebrovascular disease, and neurodegeneration biomarkers are associated with cognitive trajectories in a racially and ethnically diverse, community-based sample

Lao, PJ., et al.
2022,  
Human Molecular Genetics

Genetic architecture of RNA editing regulation in Alzheimer's disease across diverse ancestral populations

Gardner, OK., et al.
2022,  
Genes

Mining High-Level Imaging Genetic Associations via Clustering AD Candidate Variants with Similar Brain Association Patterns

Wu, R., et al.
2022,  
Proceedings of the National Academy of Sciences of the United States of America

Astrocyte-secreted glypican-4 drives APOE4-dependent tau hyperphosphorylation

Saroja, SR., et al.
2022,  
Science (New York, N.Y.)

Functional regulatory variants implicate distinct transcriptional networks in dementia

Cooper, YA., et al.
2022,  
Bioinformatics (Oxford, England)

Omnibus and Robust Deconvolution Scheme for Bulk RNA Sequencing Data Integrating Multiple Single-Cell Reference Sets and Prior Biological Knowledge

Chen, C., et al.
2022,  
Nature Communications

Cross-tissue analysis of blood and brain epigenome-wide association studies in Alzheimer's disease

C Silva, T., et al.
2022,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Differential diagnosis of amnestic dementia patients based on an FDG-PET signature of autopsy-confirmed LATE-NC

Grothe, MJ., et al.
2022,  
Human Molecular Genetics

Scalable approaches for functional analyses of whole-genome sequencing non-coding variants

Kuksa, PP., et al.
2022,  
Brain: A Journal of Neurology

Epigenetic and integrative cross-omics analyses of cerebral white matter hyperintensities on MRI

Yang, Y., et al.
2022,  
Neuropsychology

Cognitive domain harmonization and cocalibration in studies of older adults

Mukherjee, S., et al.
2022,  
BMC medical genomics

Identifying genetic markers enriched by brain imaging endophenotypes in Alzheimer's disease

Kim, M., et al.
2022,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Plasma p-tau181 shows stronger network association to Alzheimer's disease dementia than neurofilament light and total tau

Frank, B., et al.
2022,  
Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism

Genome-wide association study of brain arteriolosclerosis

Shade, LM., et al.
2022,  
Journal of Alzheimer's disease: JAD

The Advisory Group on Risk Evidence Education for Dementia: Multidisciplinary and Open to All

Rosen, AC., et al.
2022,  
Brain: A Journal of Neurology

Sex differences in the genetic architecture of cognitive resilience to Alzheimer's disease

Eissman, JM., et al.
2022,  
Translational Psychiatry

Polygenic resilience scores capture protective genetic effects for Alzheimer's disease

Hou, J., et al.
2022,  
Human Molecular Genetics

Accounting for nonlinear effects of gene expression identifies additional associated genes in transcriptome-wide association studies

Lin, Z., et al.
2022,  
Cells

A Method for Bridging Population-Specific Genotypes to Detect Gene Modules Associated with Alzheimer's Disease

Dai, Y., et al.
2022,  
HGG advances

The genetic architecture of Alzheimer disease risk in the Ohio and Indiana Amish

Osterman, MD., et al.
2022,  
Nucleic Acids Research

EPIMUTESTR: a nearest neighbor machine learning approach to predict cancer driver genes from the evolutionary action of coding variants

Parvandeh, S., et al.
2022,  
PLoS genetics

A locus at 19q13.31 significantly reduces the ApoE ε4 risk for Alzheimer's Disease in African Ancestry

Rajabli, F., et al.
2022,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Contribution of Alzheimer's biomarkers and risk factors to cognitive impairment and decline across the Alzheimer's disease continuum

Tosun, D., et al.
2022,  
JAMA neurology

Association of Rare APOE Missense Variants V236E and R251G With Risk of Alzheimer Disease

Le Guen, Y., et al.
2022,  
Acta Neuropathologica

FMNL2 regulates gliovascular interactions and is associated with vascular risk factors and cerebrovascular pathology in Alzheimer's disease

Lee, AJ., et al.
2022,  
Stem Cell Research

Generation of two iPSC lines (UMi038-A & UMi039-A) from siblings bearing an Alzheimer's disease-associated variant in SORL1

DeRosa, BA., et al.
2022,  
Annals of Neurology

Association of Apolipoprotein E ɛ4 Allele with Enlarged Perivascular Spaces

Pinheiro, A., et al.
2022,  
Brain: A Journal of Neurology

Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidate

Mishra, A., et al.
2022,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Genome-wide association and multi-omics studies identify MGMT as a novel risk gene for Alzheimer's disease among women

Chung, J., et al.
2022,  
Biological Psychiatry

Integrative Co-methylation Network Analysis Identifies Novel DNA Methylation Signatures and Their Target Genes in Alzheimer's Disease

Kim, JP., et al.
2022,  
Cell

Cholesterol and matrisome pathways dysregulated in astrocytes and microglia

Tcw, J., et al.
2022,  
American Journal of Human Genetics

Genome-wide association meta-analysis identifies 48 risk variants and highlights the role of the stria vascularis in hearing loss

Trpchevska, N., et al.
2022,  
BMC genomics

Integrative analysis of summary data from GWAS and eQTL studies implicates genes differentially expressed in Alzheimer's disease

Lee, B., et al.
2022,  
American Journal of Human Genetics

Integration of rare expression outlier-associated variants improves polygenic risk prediction

Smail, C., et al.
2022,  
Biological Psychiatry. Cognitive Neuroscience and Neuroimaging

Genomic Studies Across the Lifespan Point to Early Mechanisms Determining Subcortical Volumes

Le Grand, Q., et al.
2022,  
Molecular Psychiatry

Admixture Mapping of Alzheimer's disease in Caribbean Hispanics identifies a new locus on 22q13.1

Kizil, C., et al.
2022,  
Nature Protocols

Chromatin accessibility profiling by ATAC-seq

Grandi, FC., et al.
2022,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Integrative metabolomics-genomics approach reveals key metabolic pathways and regulators of Alzheimer's disease

Horgusluoglu, E., et al.
2022,  
Aging Cell

Alzheimer's disease associated AKAP9 I2558M mutation alters posttranslational modification and interactome of tau and cellular functions in CRISPR-edited human neuronal cells

You, Y., et al.
2022,  
Cells

Single Cell/Nucleus Transcriptomics Comparison in Zebrafish and Humans Reveals Common and Distinct Molecular Responses to Alzheimer's Disease

Cosacak, MI., et al.
2022,  
Neurology

Genetic Risk, Midlife Life's Simple 7, and Incident Dementia in the Atherosclerosis Risk in Communities Study

Tin, A., et al.
2022,  
Nucleic Acids Research

MethReg: estimating the regulatory potential of DNA methylation in gene transcription

Silva, TC., et al.
2022,  
Scientific Reports

Genome-wide association of polygenic risk extremes for Alzheimer's disease in the UK Biobank

Gouveia, C., et al.
2022,  
Journal of Neuroinflammation

High-fat diet exacerbates cognitive decline in mouse models of Alzheimer's disease and mixed dementia in a sex-dependent manner

Gannon, OJ., et al.
2022,  
Brain: A Journal of Neurology

Antemortem plasma phosphorylated tau (181) predicts Alzheimer's disease neuropathology and regional tau at autopsy

Morrison, MS., et al.
2022,  
JAMA psychiatry

Characterizing Heterogeneity in Neuroimaging, Cognition, Clinical Symptoms, and Genetics Among Patients With Late-Life Depression

Wen, J., et al.
2022,  
Genome Research

A general calculus of fitness landscapes finds genes under selection in cancers

Hsu, T., et al.
2022,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Genetic variants in the SHISA6 gene are associated with delayed cognitive impairment in two family datasets

Ramos, J., et al.
2022,  
European Journal of Neurology

Rare variants in TP73 in a frontotemporal dementia cohort link this gene with primary progressive aphasia phenotypes

Tábuas-Pereira, M., et al.
2022,  
Current Protocols

Molecular Quantitative Trait Locus Mapping in Human Complex Diseases

Olayinka, OA., et al.
2022,  
Annals of Clinical and Translational Neurology

Correlation of plasma and neuroimaging biomarkers in Alzheimer's disease

Brickman, AM., et al.
2022,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Current directions in tau research: Highlights from Tau 2020

Sexton, C., et al.
2022,  
Cells

Identifying Blood Biomarkers for Dementia Using Machine Learning Methods in the Framingham Heart Study

Lin, H., et al.
2022,  
Neurology

Multiple Cortical to Striatal Accumulation Trajectories of β-Amyloid: Do All Roads Lead to Rome?

Vogel, JW.
2022,  
Neuron

ApoE Cascade Hypothesis in the pathogenesis of Alzheimer's disease and related dementias

Martens, YA., et al.
2022,  
Journal of Medical Internet Research

Associations Between the Digital Clock Drawing Test and Brain Volume: Large Community-Based Prospective Cohort (Framingham Heart Study)

Yuan, J., et al.
2022,  
Scientific Reports

Manifestations of Alzheimer's disease genetic risk in the blood are evident in a multiomic analysis in healthy adults aged 18 to 90

Heath, L., et al.
2022,  
Med (New York, N.Y.)

Integrating functional genomics with genetics to understand the biology of ALS and FTD

Cruchaga, C.
2022,  
Communications Biology

Meta-analysis of genome-wide association studies identifies ancestry-specific associations underlying circulating total tau levels

Sarnowski, C., et al.
2022,  
American Journal of Human Genetics

Family history aggregation unit-based tests to detect rare genetic variant associations with application to the Framingham Heart Study

Wang, Y., et al.
2022,  
Circulation

Circulating Metabolome and White Matter Hyperintensities in Women and Men

Sliz, E., et al.
2022,  
Neurobiology of Disease

Soluble TREM2: Innocent bystander or active player in neurological diseases?

Filipello, F., et al.
2022,  
Journal of the International Neuropsychological Society: JINS

Midlife Vascular Factors and Prevalence of Mild Cognitive Impairment in Late-Life in Mexico

Arce Rentería, M., et al.
2022,  
Nature Genetics

New insights into the genetic etiology of Alzheimer's disease and related dementias

Bellenguez, C., et al.
2022,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Replication study of AD-associated rare variants

Neupane, A., et al.
2022,  
Genome Research

An association test of the spatial distribution of rare missense variants within protein structures identifies Alzheimer's disease-related patterns

Jin, B., et al.
2022,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Midlife lipid and glucose levels are associated with Alzheimer's disease

Zhang, X., et al.
2022,  
Briefings in Bioinformatics

Deep learning-based identification of genetic variants: application to Alzheimer's disease classification

Jo, T., et al.
2022,  
Acta Neuropathologica Communications

Circular RNA detection identifies circPSEN1 alterations in brain specific to autosomal dominant Alzheimer's disease

Chen, H., et al.
2022,  
NeuroImage

Deep learning for Alzheimer's disease: Mapping large-scale histological tau protein for neuroimaging biomarker validation

Ushizima, D., et al.
2022,  
NAR genomics and bioinformatics

FILER: a framework for harmonizing and querying large-scale functional genomics knowledge

Kuksa, PP., et al.
2022,  
Journal of magnetic resonance imaging: JMRI

Deep Generative Medical Image Harmonization for Improving Cross-Site Generalization in Deep Learning Predictors

Bashyam, VM., et al.
2022,  
Alzheimer's Research & Therapy

Blood and brain transcriptome analysis reveals APOE genotype-mediated and immune-related pathways involved in Alzheimer disease

Panitch, R., et al.
2022,  
Social Science & Medicine (1982)

Longitudinal associations between racial discrimination and hippocampal and white matter hyperintensity volumes among older Black adults

Zahodne, LB., et al.
2022,  
Alzheimer's Research & Therapy

Challenges at the APOE locus: a robust quality control approach for accurate APOE genotyping

Belloy, ME., et al.
2022,  
Medical Image Analysis

Embracing the disharmony in medical imaging: A Simple and effective framework for domain adaptation

Wang, R., et al.
2022,  
Aging Cell

Aging-related cell type-specific pathophysiologic immune responses that exacerbate disease severity in aged COVID-19 patients

Hou, Y., et al.
2022,  
Current Opinion in Structural Biology

Interpretable artificial intelligence and exascale molecular dynamics simulations to reveal kinetics: Applications to Alzheimer's disease

Martin, W., et al.
2022,  
Neurology. Genetics

Confirming Pathogenicity of the F386L PSEN1 Variant in a South Asian Family With Early-Onset Alzheimer Disease

Eger, SJ., et al.
2022,  
Genetic Epidemiology

Precisely modeling zero-inflated count phenotype for rare variants

Fan, Q., et al.
2022,  
Neurobiology of Aging

Cognitive reserve proxies, Alzheimer pathologies, and cognition

Ko, K., et al.
2022,  
BMC genomics

Genome-Wide association study of quantitative biomarkers identifies a novel locus for alzheimer's disease at 12p12.1

Lee, B., et al.
2022,  
European Journal of Hybrid Imaging

Regional uptakes from early-frame amyloid PET and 18F-FDG PET scans are comparable independent of disease state

Myoraku, A., et al.
2022,  
Molecular Neurodegeneration

Murine roseolovirus does not accelerate amyloid-β pathology and human roseoloviruses are not over-represented in Alzheimer disease brains

Bigley, TM., et al.
2022,  
Biomedicines

Phenotypic Heterogeneity among GBA p.R202X Carriers in Lewy Body Spectrum Disorders

Napolioni, V., et al.
2022,  
Alzheimer's Research & Therapy

Artificial intelligence framework identifies candidate targets for drug repurposing in Alzheimer's disease

Fang, J., et al.
2022,  
Molecular Neurodegeneration

Challenge accepted: uncovering the role of rare genetic variants in Alzheimer's disease

Khani, M., et al.
2022,  
Neurology

Predictors of Incident Mild Cognitive Impairment and Its Course in a Diverse Community-Based Population

Angevaare, MJ., et al.
2022,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Harmonizing neuropsychological assessment for mild neurocognitive disorders in Europe

Boccardi, M., et al.
2022,  
Alzheimer's & Dementia (New York, N. Y.)

The Alzheimer's Cell Atlas (TACA): A single-cell molecular map for translational therapeutics accelerator in Alzheimer's disease

Zhou, Y., et al.
2022,  
Journal of Alzheimer's disease: JAD

Alzheimer's Disease Variant Portal: A Catalog of Genetic Findings for Alzheimer's Disease

Kuksa, PP., et al.
2022,  
Journal of Alzheimer's disease: JAD

Polygenic Risk Scores in Alzheimer's Disease Genetics: Methodology, Applications, Inclusion, and Diversity

Clark, K., et al.
2022,  
Frontiers in Molecular Neuroscience

Cell type-specific histone acetylation profiling of Alzheimer's disease subjects and integration with genetics

Ramamurthy, E., et al.
2022,  
AMIA ... Annual Symposium proceedings. AMIA Symposium

A knowledge graph-based disease-gene prediction system using multi-relational graph convolution networks

Gao, Z., et al.
2022,  
PloS One

SPARE-Tau: A flortaucipir machine-learning derived early predictor of cognitive decline

Toledo, JB., et al.
2022,  
PloS One

Gut microbiome alterations in preclinical Alzheimer's disease

Jung, JH., et al.
2022,  
Alzheimer's & Dementia (Amsterdam, Netherlands)

Immunity gene IFITM3 variant: Relation to cognition and Alzheimer's disease pathology

Pyun, J., et al.
2022,  
Alzheimer's & Dementia (Amsterdam, Netherlands)

Network-wise concordance of multimodal neuroimaging features across the Alzheimer's disease continuum

Stocks, J., et al.
2022,  
PloS One

Leveraging large multi-center cohorts of Alzheimer disease endophenotypes to understand the role of Klotho heterozygosity on disease risk

Ali, M., et al.
2022,  
Journal of Alzheimer's disease: JAD

Comparative Analysis of Alzheimer's Disease Cerebrospinal Fluid Biomarkers Measurement by Multiplex SOMAscan Platform and Immunoassay-Based Approach

Timsina, J., et al.
2022,  
Human Brain Mapping

Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3-90 years

Dima, D., et al.
2022,  
Nature Genetics

Genetic analysis of the human microglial transcriptome across brain regions, aging and disease pathologies

Lopes, KdP., et al.
2022,  
Human Brain Mapping

Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3-90 years

Frangou, S., et al.
2022,  
Acta Neuropathologica

Genome-wide association study and functional validation implicates JADE1 in tauopathy

Farrell, K., et al.
2022,  
Frontiers in Neurology

Exome Sequencing of a Portuguese Cohort of Frontotemporal Dementia Patients: Looking Into the ALS-FTD Continuum

Tábuas-Pereira, M., et al.
2022,  
Brain Communications

Disentangling Alzheimer's disease neurodegeneration from typical brain ageing using machine learning

Hwang, G., et al.
2022,  
Frontiers in Psychiatry

Associations of digital neuro-signatures with molecular and neuroimaging measures of brain resilience: The altoida large cohort study

Seixas, AA., et al.
2022,  
Journal of Alzheimer's disease: JAD

Measuring Subjective Cognitive Decline in Older Adults: Harmonization Between the Cognitive Change Index and the Measurement of Everyday Cognition Instruments

Wells, LF., et al.
2022,  
Journal of Alzheimer's disease: JAD

Late-Life Physical Activities Moderate the Relationship of Amyloid-β Pathology with Neurodegeneration in Individuals Without Dementia

Sohn, BK., et al.
2022,  
Journal of Alzheimer's disease: JAD

Functional Neural Correlates of Semantic Fluency Task Performance in Mild Cognitive Impairment and Alzheimer's Disease: An FDG-PET Study

Ahn, H., et al.

2021

2021,  
Proceedings of the National Academy of Sciences of the United States of America

Neuronal ROS-induced glial lipid droplet formation is altered by loss of Alzheimer's disease-associated genes

Moulton, MJ., et al.
2021,  
Scientific Reports

Using imputation to provide harmonized longitudinal measures of cognition across AIBL and ADNI

Shishegar, R., et al.
2021,  
Translational Psychiatry

Genetically regulated expression in late-onset Alzheimer's disease implicates risk genes within known and novel loci

Chen, H., et al.
2021,  
Translational Psychiatry

Association of low-frequency and rare coding variants with information processing speed

Bressler, J., et al.
2021,  
Nature Communications

A deep learning framework identifies dimensional representations of Alzheimer's Disease from brain structure

Yang, Z., et al.
2021,  
American Journal of Human Genetics

Genome-wide analysis of common and rare variants via multiple knockoffs at biobank scale, with an application to Alzheimer disease genetics

He, Z., et al.
2021,  
Nature Aging

Endophenotype-based in silico network medicine discovery combined with insurance record data mining identifies sildenafil as a candidate drug for Alzheimer's disease

Fang, J., et al.
2021,  
Alzheimer's Research & Therapy

Serum zinc levels and in vivo beta-amyloid deposition in the human brain

Kim, JW., et al.
2021,  
Translational Psychiatry

A missense variant in SHARPIN mediates Alzheimer's disease-specific brain damages

Park, JY., et al.
2021,  
Alzheimer's Research & Therapy

Dysregulated expression levels of APH1B in peripheral blood are associated with brain atrophy and amyloid-β deposition in Alzheimer's disease

Park, YH., et al.
2021,  
IEEE transactions on bio-medical engineering

Improved Prediction of Cognitive Outcomes via Globally Aligned Imaging Biomarker Enrichments Over Progressions

Lu, L., et al.
2021,  
European journal of human genetics: EJHG

Exploiting family history in aggregation unit-based genetic association tests

Wang, Y., et al.
2021,  
Cells

KYNA/Ahr Signaling Suppresses Neural Stem Cell Plasticity and Neurogenesis in Adult Zebrafish Model of Alzheimer's Disease

Siddiqui, T., et al.
2021,  
Alzheimer's Research & Therapy

BMI1 is associated with CS8F amyloid-β and rates of cognitive decline in Alzheimer's disease

Kim, JP., et al.
2021,  
JAMA network open

Association of Regional White Matter Hyperintensities With Longitudinal Alzheimer-Like Pattern of Neurodegeneration in Older Adults

Rizvi, B., et al.
2021,  
Molecular Psychiatry

Integrative brain transcriptome analysis links complement component 4 and HSPA2 to the APOE ε2 protective effect in Alzheimer disease

Panitch, R., et al.
2021,  
Molecular Psychiatry

Genome-wide association identifies the first risk loci for psychosis in Alzheimer disease

DeMichele-Sweet, MAA., et al.
2021,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Plasma amyloid β levels are driven by genetic variants near APOE, BACE1, APP, PSEN2: A genome-wide association study in over 12,000 non-demented participants

Damotte, V., et al.
2021,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Dementia in Africa: Current evidence, knowledge gaps, and future directions

Akinyemi, RO., et al.
2021,  
Nature Neuroscience

Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders

Yang, C., et al.
2021,  
Annals of Neurology

Polygenic Risk Score for Alzheimer's Disease in Caribbean Hispanics

Sariya, S., et al.
2021,  
PLoS genetics

Rare variants in the endocytic pathway are associated with Alzheimer's disease, its related phenotypes, and functional consequences

Zhan, L., et al.
2021,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Midlife vascular risk factors and risk of incident dementia: Longitudinal cohort and Mendelian randomization analyses in the UK Biobank

Malik, R., et al.
2021,  
Translational Neurodegeneration

Predictability of polygenic risk score for progression to dementia and its interaction with APOE ε4 in mild cognitive impairment

Pyun, J., et al.
2021,  
Neurobiology of Aging

Linkage of Alzheimer disease families with Puerto Rican ancestry identifies a chromosome 9 locus

Rajabli, F., et al.
2021,  
Translational Psychiatry

Heterogeneous effects of genetic risk for Alzheimer's disease on the phenome

Wu, HM., et al.
2021,  
Alzheimer's Research & Therapy

Admixture mapping reveals the association between Native American ancestry at 3q13.11 and reduced risk of Alzheimer's disease in Caribbean Hispanics

Horimoto, ARVR., et al.
2021,  
Medical Image Analysis

A structural enriched functional network: An application to predict brain cognitive performance

Kim, M., et al.
2021,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Increased APOE ε4 expression is associated with the difference in Alzheimer's disease risk from diverse ancestral backgrounds

Griswold, AJ., et al.
2021,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Association of mitochondrial variants and haplogroups identified by whole exome sequencing with Alzheimer's disease

Zhang, X., et al.
2021,  
Nature Communications

Common variants in Alzheimer's disease and risk stratification by polygenic risk scores

de Rojas, I., et al.
2021,  
Journal of Genetic Counseling

Genetic counseling for early onset and familial dementia: Patient perspectives on exome sequencing

Rolf, B., et al.
2021,  
Neurobiology of Disease

Deconstructing the epigenomic architecture of human neurodegeneration

De Jager, PL.
2021,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

The chronic neuropsychiatric sequelae of COVID-19: The need for a prospective study of viral impact on brain functioning

de Erausquin, GA., et al.
2021,  
Stroke

Autonomic Imbalance and Risk of Dementia and Stroke: The Framingham Study

Weinstein, G., et al.
2021,  
The European Journal of Neuroscience

Lifelong chronic psychosocial stress induces a proteomic signature of Alzheimer's disease in wildtype mice

Lyons, CE., et al.
2021,  
Nature Communications

Identification of putative causal loci in whole-genome sequencing data via knockoff statistics

He, Z., et al.
2021,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Social network characteristics moderate associations between cortical thickness and cognitive functioning in older adults

Sharifian, N., et al.
2021,  
Neurobiology of Aging

Dissecting the role of Amerindian genetic ancestry and the ApoE ε4 allele on Alzheimer disease in an admixed Peruvian population

Marca-Ysabel, MV., et al.
2021,  
Acta Neuropathologica

Proteomic identification of select protein variants of the SNARE interactome associated with cognitive reserve in a large community sample

Ramos-Miguel, A., et al.
2021,  
Translational Psychiatry

Cell-type-specific expression quantitative trait loci associated with Alzheimer disease in blood and brain tissue

Patel, D., et al.
2021,  
Acta Neuropathologica Communications

Sex-specific DNA methylation differences in Alzheimer's disease pathology

Zhang, L., et al.
2021,  
Journal of Neuropathology and Experimental Neurology

Asymmetry of Hippocampal Tau Pathology in Primary Age-Related Tauopathy and Alzheimer Disease

Walker, JM., et al.
2021,  
Aging

Multiomics integrative analysis identifies APOE allele-specific blood biomarkers associated to Alzheimer's disease etiopathogenesis

Madrid, L., et al.
2021,  
Genetic Epidemiology

An exploration of genetic association tests for disease risk and age at onset

Martin, ER., et al.
2021,  
Stem Cell Research

Derivation of stem cell line UMi028-A-2 containing a CRISPR/Cas9 induced Alzheimer's disease risk variant p.S1038C in the TTC3 gene

Laverde-Paz, MJ., et al.
2021,  
Acta Neuropathologica

Lack of evidence supporting a role for DPP6 sequence variants in Alzheimer's disease in the European American population

Kirola, L., et al.
2021,  
Neurology

Amyloid PET Imaging in Self-Identified Non-Hispanic Black Participants of the Anti-Amyloid in Asymptomatic Alzheimer's Disease (A4) Study

Deters, KD., et al.
2021,  
Genes

Set-Based Rare Variant Expression Quantitative Trait Loci in Blood and Brain from Alzheimer Disease Study Participants

Patel, D., et al.
2021,  
Nature Communications

Integration of Alzheimer's disease genetics and myeloid genomics identifies disease risk regulatory elements and genes

Novikova, G., et al.
2021,  
Alzheimer's Research & Therapy

Genome-wide epistasis analysis for Alzheimer's disease and implications for genetic risk prediction

Wang, H., et al.
2021,  
American Journal of Human Genetics

Genetic control of the human brain proteome

Robins, C., et al.
2021,  
Molecular Psychiatry

Brain expression of the vascular endothelial growth factor gene family in cognitive aging and alzheimer's disease

Mahoney, ER., et al.
2021,  
Neurobiology of Aging

Greater effect of polygenic risk score for Alzheimer's disease among younger cases who are apolipoprotein E-ε4 carriers

Fulton-Howard, B., et al.
2021,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

APOE alleles' association with cognitive function differs across Hispanic/Latino groups and genetic ancestry in the study of Latinos-investigation of neurocognitive aging (HCHS/SOL)

Granot-Hershkovitz, E., et al.
2021,  
Nature Genetics

Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture

Chia, R., et al.
2021,  
Translational Psychiatry

Long runs of homozygosity are associated with Alzheimer's disease

Moreno-Grau, S., et al.
2021,  
Neuron

Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis

Dewan, R., et al.
2021,  
Acta Neuropathologica

In vitro amplification of pathogenic tau conserves disease-specific bioactive characteristics

Xu, H., et al.
2021,  
Nature Genetics

Integrating human brain proteomes with genome-wide association data implicates new proteins in Alzheimer's disease pathogenesis

Wingo, AP., et al.
2021,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Non-coding variants in MYH11, FZD3, and SORCS3 are associated with dementia in women

Blue, EE., et al.
2021,  
Neuron

Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer's Disease

Wang, M., et al.
2021,  
Current Neurology and Neuroscience Reports

Early-Onset Alzheimer's Disease: What Is Missing in Research?

Ayodele, T., et al.
2021,  
Translational Psychiatry

A cortical immune network map identifies distinct microglial transcriptional programs associated with β-amyloid and Tau pathologies

Patrick, E., et al.
2021,  
Genome Biology

The variant call format provides efficient and robust storage of GWAS summary statistics

Lyon, MS., et al.
2021,  
JAMA neurology

Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis

Kunkle, BW., et al.
2021,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Education differentially contributes to cognitive reserve across racial/ethnic groups

Avila, JF., et al.
2021,  
Molecular Psychiatry

Genome-wide association study of brain amyloid deposition as measured by Pittsburgh Compound-B (PiB)-PET imaging

Yan, Q., et al.
2021,  
Journal of the American Geriatrics Society

A Systematic Review of Delirium Biomarkers and Their Alignment with the NIA-AA Research Framework

Wang, S., et al.
2021,  
Science Advances

Molecular subtyping of Alzheimer's disease using RNA sequencing data reveals novel mechanisms and targets

Neff, RA., et al.
2021,  
Annals of Neurology

Causal Associations Between Modifiable Risk Factors and the Alzheimer's Phenome

Andrews, SJ., et al.
2021,  
PLoS genetics

Identifying drug targets for neurological and psychiatric disease via genetics and the brain transcriptome

Baird, DA., et al.
2021,  
Frontiers in Neuroscience

Predicting Brain Amyloid Using Multivariate Morphometry Statistics, Sparse Coding, and Correntropy: Validation in 1,101 Individuals From the ADNI and OASIS Databases

Wu, J., et al.
2021,  
Methods in Molecular Biology (Clifton, N.J.)

Using INFERNO to Infer the Molecular Mechanisms Underlying Noncoding Genetic Associations

Amlie-Wolf, A., et al.
2021,  
Journal of Alzheimer's disease: JAD

Lower Levels of Education Are Associated with Cognitive Impairment in the Old Order Amish

Ramos, J., et al.
2021,  
Alzheimer's & Dementia (Amsterdam, Netherlands)

Large-scale sequencing studies expand the known genetic architecture of Alzheimer's disease

Xue, D., et al.

2020

2020,  
BMC bioinformatics

Deep learning detection of informative features in tau PET for Alzheimer's disease classification

Jo, T., et al.
2020,  
Science Translational Medicine

Chi3l1/YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer's disease pathogenesis

Lananna, BV., et al.
2020,  
BMC medical informatics and decision making

Cognitive biomarker prioritization in Alzheimer's Disease using brain morphometric data

Peng, B., et al.
2020,  
European journal of human genetics: EJHG

A quantitative trait rare variant nonparametric linkage method with application to age-at-onset of Alzheimer's disease

Zhao, L., et al.
2020,  
NeuroImage

A comparison of Freesurfer and multi-atlas MUSE for brain anatomy segmentation: Findings about size and age bias, and inter-scanner stability in multi-site aging studies

Srinivasan, D., et al.
2020,  
Trends in Neurosciences

Microglial Phagocytosis: A Disease-Associated Process Emerging from Alzheimer's Disease Genetics

Podleśny-Drabiniok, A., et al.
2020,  
Acta Neuropathologica Communications

Functional genomic analyses uncover APOE-mediated regulation of brain and cerebrospinal fluid beta-amyloid levels in Parkinson disease

Ibanez, L., et al.
2020,  
IEEE transactions on medical imaging

Associating Multi-Modal Brain Imaging Phenotypes and Genetic Risk Factors via a Dirty Multi-Task Learning Method

Du, L., et al.
2020,  
Molecular Psychiatry

Genetic data and cognitively defined late-onset Alzheimer's disease subgroups

Mukherjee, S., et al.
2020,  
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

Parental History of Dementia Is Associated with Increased Small Vessel Cerebrovascular Disease

Stamm, BC., et al.
2020,  
NeuroImage

Longitudinal ComBat: A method for harmonizing longitudinal multi-scanner imaging data

Beer, JC., et al.
2020,  
JAMA neurology

Association Between Common Variants in RBFOX1, an RNA-Binding Protein, and Brain Amyloidosis in Early and Preclinical Alzheimer Disease

Raghavan, NS., et al.
2020,  
JAMA network open

Association of Uncommon, Noncoding Variants in the APOE Region With Risk of Alzheimer Disease in Adults of European Ancestry

Blue, EE., et al.
2020,  
Neurobiology of Aging

LRP10 variants in progressive supranuclear palsy

Vergouw, LJM., et al.
2020,  
Acta Neuropathologica

TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis

Cignarella, F., et al.
2020,  
Nature

Negative feedback control of neuronal activity by microglia

Badimon, A., et al.
2020,  
Nature Communications

Risk prediction of late-onset Alzheimer's disease implies an oligogenic architecture

Zhang, Q., et al.
2020,  
Nature Communications

Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults

Hofer, E., et al.
2020,  
Neurology

Cardiovascular health, genetic risk, and risk of dementia in the Framingham Heart Study

Peloso, GM., et al.
2020,  
EMBO molecular medicine

Higher CSF sTREM2 and microglia activation are associated with slower rates of beta-amyloid accumulation

Ewers, M., et al.
2020,  
Alzheimer's Research & Therapy

Analysis of brain region-specific co-expression networks reveals clustering of established and novel genes associated with Alzheimer disease

Lancour, D., et al.
2020,  
Journal of Neuropathology and Experimental Neurology

Insoluble Tau From Human FTDP-17 Cases Exhibit Unique Transmission Properties In Vivo

Weitzman, SA., et al.
2020,  
Cell Reports

Cross-Species Analyses Identify Dlgap2 as a Regulator of Age-Related Cognitive Decline and Alzheimer's Dementia

Ouellette, AR., et al.
2020,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Genome-wide transcriptome analysis identifies novel dysregulated genes implicated in Alzheimer's pathology

Nho, K., et al.
2020,  
Neurobiology of Disease

Genetic architecture of Alzheimer's disease

Neuner, SM., et al.
2020,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Circulating ethanolamine plasmalogen indices in Alzheimer's disease: Relation to diagnosis, cognition, and CSF tau

Kling, MA., et al.
2020,  
Genome Biology

PSCAN: Spatial scan tests guided by protein structures improve complex disease gene discovery and signal variant detection

Tang, Z., et al.
2020,  
Journal of the American Geriatrics Society

Measurement and Structure of Cognition in the Longitudinal Aging Study in India-Diagnostic Assessment of Dementia

Gross, AL., et al.
2020,  
Journal of the American Geriatrics Society

Introduction to LASI-DAD: The Longitudinal Aging Study in India-Diagnostic Assessment of Dementia

Lee, J.
2020,  
Journal of the American Geriatrics Society

Design and Methodology of the Longitudinal Aging Study in India-Diagnostic Assessment of Dementia (LASI-DAD)

Lee, J., et al.
2020,  
Journal of the American Geriatrics Society

Association Between Episodic Memory and Genetic Risk Factors for Alzheimer's Disease in South Asians from the Longitudinal Aging Study in India-Diagnostic Assessment of Dementia (LASI-DAD)

Smith, JA., et al.
2020,  
Neurology. Genetics

Synonymous variants associated with Alzheimer disease in multiplex families

Tang, M., et al.
2020,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Genome-wide association study of rate of cognitive decline in Alzheimer's disease patients identifies novel genes and pathways

Sherva, R., et al.
2020,  
Neurobiology of Disease

Genetic architecture of common non-Alzheimer's disease dementias

Guerreiro, R., et al.
2020,  
PLoS genetics

On the cross-population generalizability of gene expression prediction models

Keys, KL., et al.
2020,  
Brain: A Journal of Neurology

Genetic variants and functional pathways associated with resilience to Alzheimer's disease

Dumitrescu, L., et al.
2020,  
Molecular Psychiatry

Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation

Bis, JC., et al.
2020,  
Journal of the American Geriatrics Society

Hypertension and Cognitive Health Among Older Adults in India

Farron, MR., et al.
2020,  
Journal of the American Geriatrics Society

New Insights and Knowledge on Cognition and Dementia from Population-Based Cohort of Older Adults in India

Kenny, RA.
2020,  
Journal of the American Geriatrics Society

Online Clinical Consensus Diagnosis of Dementia: Development and Validation

Lee, J., et al.