Genetic Analysis

Alzheimer Disease Sequence Analysis Collaborative (CADRE)

U01 AG058654

Principal investigators:
Jonathan Haines,
William Bush,
Lindsay Farrer,
Eden Martin,
Margaret Pericak-Vance

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The primary goal of the Alzheimer Disease Sequence Analysis Collaborative (aka CADRE) is to analyze sequence data from ethnically diverse AD/ADRD datasets using state-of-the-art approaches, and to translate these findings into high-priority therapeutic targets. CADRE has 3 specific aims that are performed in parallel and iteratively, with regular cross-communication. Specific Aim 1 will analyze the data within each ethnicity adjusting for global ancestry as necessary and ultimately combining the data in a trans-ethnic analysis. Specific Aim 2 will delve deeper into ancestry-specific effects using local-ancestry admixture measures; these results will inform analyses in Specific Aim 1. Both of these aims will identify statistically significant and suggestive loci. Specific Aim 3 will integrate additional functional data (e.g., eQTL, mQTL) to inform additional analyses for the first two specific aims, in addition to integrating these results with extant biological information to inform and prioritize potential therapeutic targets.

Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE)

U01 AG058589

Principal investigators:
Anita Destefano,
Eric Boerwinkle,
Philip De Jager,
Myriam Fornage,
Sudha Seshadri,
Ellen Wijsman

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The Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium is a network of investigators involved in prospective cohort studies. Cohort study participants are deeply phenotyped and followed over time to surveil for incident disease. CHARGE study participants were included in the Discovery phase of the ADSP. WGS for additional CHARGE study participants has been generated via TOPMed. CHARGE investigators and additional collaborators are funded as one of the ADSP FUS-A U01 grants.