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2024

2024,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

The Health Equity Scholars Program: Fostering Culturally Competent and Successful Independent Investigators in Alzheimer's Disease and Related Dementia Research.

Amaza, H., et al.
2024,  
Journal of the International Neuropsychological Society : JINS

Impact of white matter hyperintensity volume on cognition among US Mexican American adults.

Graves, LV., et al.
2024,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Dementia risk scores, apolipoprotein E, and risk of Alzheimer's disease: One size does not fit all.

Andrews, SJ., et al.
2024,  
Journal of chemical theory and computation

Accounting for Fast vs Slow Exchange in Single Molecule FRET Experiments Reveals Hidden Conformational States.

Miller, JJ., et al.
2024,  
Nature neuroscience

Opportunities and challenges of single-cell and spatially resolved genomics methods for neuroscience discovery.

Bonev, B., et al.
2024,  
International journal of obesity (2005)

Effects of high fat diet on metabolic health vary by age of menopause onset.

Salinero, AE., et al.
2024,  
Nature genetics

Genetic architecture of cerebrospinal fluid and brain metabolite levels and the genetic colocalization of metabolites with human traits.

Wang, C., et al.
2024,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Latent change-on-change between amyloid accumulation and cognitive decline.

Klinger, HM., et al.
2024,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Gaps in biomedical research in frontotemporal dementia: A call for diversity and disparities focused research.

Nuytemans, K., et al.
2024,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Pathway enrichment in genome-wide analysis of longitudinal Alzheimer's disease biomarker endophenotypes.

Rosewood, TJ., et al.
2024,  
ACM-BCB ... ... : the ... ACM Conference on Bioinformatics, Computational Biology and Biomedicine. ACM Conference on Bioinformatics, Computational Biology and Biomedicine

Causality-based Subject and Task Fingerprints using fMRI Time-series Data.

Song, D., et al.
2024,  
medRxiv : the preprint server for health sciences

Efficient multi-phenotype genome-wide analysis identifies genetic associations for unsupervised deep-learning-derived high-dimensional brain imaging phenotypes.

Guo, B., et al.
2024,  
IEEE transactions on pattern analysis and machine intelligence

Novel Uncertainty Quantification Through Perturbation-Assisted Sample Synthesis.

Liu, Y., et al.
2024,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

The Alzheimer's Disease Neuroimaging Initiative-4 (ADNI-4) Engagement Core: A culturally informed, community-engaged research (CI-CER) model to advance brain health equity.

Rivera Mindt, M., et al.
2024,  
Targets (Basel)

Repurposing FDA-Approved Drugs Against Potential Drug Targets Involved in Brain Inflammation Contributing to Alzheimer's Disease.

Sharo, C., et al.
2024,  
Neurochemistry international

Ras, RhoA, and vascular pharmacology in neurodevelopment and aging.

Nussinov, R., et al.
2024,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Association of amyloid and cardiovascular risk with cognition: Findings from KBASE.

Chaudhuri, S., et al.
2024,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Genome-wide transcriptome analysis of Aβ deposition on PET in a Korean cohort.

Park, T., et al.
2024,  
bioRxiv : the preprint server for biology

Cell Type Differentiation Using Network Clustering Algorithms.

Nasrollahi, FSF., et al.
2024,  
Nature genetics

Proteogenomic analysis of human cerebrospinal fluid identifies neurologically relevant regulation and implicates causal proteins for Alzheimer's disease.

Western, D., et al.
2024,  
Nature neuroscience

A cross-disease resource of living human microglia identifies disease-enriched subsets and tool compounds recapitulating microglial states.

Tuddenham, JF., et al.
2024,  
Nature neuroscience

Integrated multimodal cell atlas of Alzheimer's disease.

Gabitto, MI., et al.
2024,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Whole-genome sequencing study in Koreans identifies novel loci for Alzheimer's disease.

Kang, M., et al.
2024,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Association of common and rare variants with Alzheimer's disease in more than 13,000 diverse individuals with whole-genome sequencing from the Alzheimer's Disease Sequencing Project.

Lee, W., et al.
2024,  
Research square

Ancestral Genomic Functional Differences in Oligodendroglia: Implications for Alzheimer's Disease.

Ramirez, AM., et al.
2024,  
medRxiv : the preprint server for health sciences

Long Sleep Duration, Cognitive Performance, and the Moderating Role of Depression: A Cross-Sectional Analysis in the Framingham Heart Study.

Young, VM., et al.
2024,  
medRxiv : the preprint server for health sciences

LD-informed deep learning for Alzheimer's gene loci detection using WGS data.

Jo, T., et al.
2024,  
medRxiv : the preprint server for health sciences

NIAGADS: A Comprehensive National Data Repository for Alzheimer's Disease and Related Dementia Genetics and Genomics Research.

Kuzma, A., et al.
2024,  
medRxiv : the preprint server for health sciences

Alzheimer's Disease Sequencing Project Release 4 Whole Genome Sequencing Dataset.

Leung, YY., et al.
2024,  
medRxiv : the preprint server for health sciences

Biobank-scale characterization of Alzheimer's disease and related dementias identifies potential disease-causing variants, risk factors, and genetic modifiers across diverse ancestries.

Khani, M., et al.
2024,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Widespread transposable element dysregulation in human aging brains with Alzheimer's disease.

Feng, Y., et al.
2024,  
Nature genetics

GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia.

Shade, LMP., et al.
2024,  
Acta neuropathologica

Pure LATE-NC: Frequency, clinical impact, and the importance of considering APOE genotype when assessing this and other subtypes of non-Alzheimer's pathologies.

Katsumata, Y., et al.
2024,  
Research square

DNA Methylation Signature of a Lifestyle-based Resilience Index for Cognitive Health.

Zhang, W., et al.
2024,  
medRxiv : the preprint server for health sciences

Distinct medical and substance use histories associate with cognitive decline in Alzheimer's Disease.

Mansel, C., et al.
2024,  
bioRxiv : the preprint server for biology

CHARMER: detecting and harmonizing high-confidence chromatin interactions across tissues and Hi-C protocols.

Cole, S., et al.
2024,  
Briefings in bioinformatics

iDOMO: identification of drug combinations via multi-set operations for treating diseases.

Zhou, X., et al.
2024,  
Journal of Alzheimer's disease : JAD

Circulating adipokines and MRI markers of brain aging in middle-aged adults from the community.

Satizabal, CL., et al.
2024,  
Journal of the International Neuropsychological Society : JINS

Heterogeneity in cognitive profiles of monolingual and bilingual Hispanic/Latino older adults in HABS-HD.

Clark, AL., et al.
2024,  
Journal of Alzheimer's disease : JAD

Neurofilament light and cognition in community-dwelling non-Hispanic Blacks.

Abdullah, L., et al.
2024,  
Nature aging

Diagnosis of Alzheimer's disease using plasma biomarkers adjusted to clinical probability.

Therriault, J., et al.
2024,  
Cell calcium

ER and SOCE Ca2+ signals are not required for directed cell migration in human iPSC-derived microglia.

Granzotto, A., et al.
2024,  
bioRxiv : the preprint server for biology

CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions.

Li, E., et al.
2024,  
Nature cancer

Differential chromatin accessibility and transcriptional dynamics define breast cancer subtypes and their lineages.

Iglesia, MD., et al.
2024,  
Acta neuropathologica

Pathologic and clinical correlates of region-specific brain GFAP in Alzheimer's disease.

Phillips, JM., et al.
2024,  
bioRxiv : the preprint server for biology

TIA1 Mediates Divergent Inflammatory Responses to Tauopathy in Microglia and Macrophages.

Webber, CJ., et al.
2024,  
Brain, behavior, and immunity

CD8+ T cells exacerbate AD-like symptoms in mouse model of amyloidosis.

Wang, X., et al.
2024,  
medRxiv : the preprint server for health sciences

Genetic Contributions to Alzheimer's Disease and Frontotemporal Dementia in Admixed Latin American Populations.

Acosta-Uribe, J., et al.
2024,  
BioData mining

Deciphering the tissue-specific functional effect of Alzheimer risk SNPs with deep genome annotation.

Pugalenthi, PV., et al.
2024,  
Genetics

Trait imputation enhances nonlinear genetic prediction for some traits.

He, R., et al.
2024,  
Nature genetics

Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries.

García-Marín, LM., et al.
2024,  
JMIR formative research

Exploring the Perspectives of Older Adults on a Digital Brain Health Platform Using Natural Language Processing: Cohort Study.

Ding, H., et al.
2024,  
bioRxiv : the preprint server for biology

CASTER-DTA: Equivariant Graph Neural Networks for Predicting Drug-Target Affinity.

Kumar, R., et al.
2024,  
Genes

Is the Relationship Between Cardiovascular Disease and Alzheimer's Disease Genetic? A Scoping Review.

Moore, A.
2024,  
Briefings in bioinformatics

QOT: Quantized Optimal Transport for sample-level distance matrix in single-cell omics.

Wang, Z., et al.
2024,  
... IEEE-EMBS International Conference on Biomedical and Health Informatics. IEEE-EMBS International Conference on Biomedical and Health Informatics

Caudal and Thalamic Segregation in White Matter Brain Network Communities in Alzheimer's Disease Population.

Xu, F., et al.
2024,  
NPJ systems biology and applications

Network medicine informed multiomics integration identifies drug targets and repurposable medicines for Amyotrophic Lateral Sclerosis.

Yu, M., et al.
2024,  
Nature neuroscience

Integration across biophysical scales identifies molecular and cellular correlates of person-to-person variability in human brain connectivity.

Ng, B., et al.
2024,  
medRxiv : the preprint server for health sciences

Mapping rare protein-coding variants on multi-organ imaging traits.

Fan, Y., et al.
2024,  
Scientific reports

De-identification is not enough: a comparison between de-identified and synthetic clinical notes.

Sarkar, AR., et al.
2024,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Integrating amyloid imaging and genetics for early risk stratification of Alzheimer's disease.

He, B., et al.
2024,  
Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology

Visual and Auditory Sensory Impairments Differentially Relate with Alzheimer's Pathology.

Byeon, G., et al.
2024,  
Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology

The Moderating Effect of Serum Vitamin D on the Relationship between Beta-amyloid Deposition and Neurodegeneration.

Park, J., et al.
2024,  
Nature communications

Network community detection via neural embeddings.

Kojaku, S., et al.
2024,  
Movement disorders : official journal of the Movement Disorder Society

Genetic Risk Factors in Isolated Dystonia Escape Genome-Wide Association Studies.

Laabs, B., et al.
2024,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Genetic analysis of cognitive preservation in the midwestern Amish reveals a novel locus on chromosome 2.

Main, LR., et al.
2024,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Missense and loss-of-function variants at GWAS loci in familial Alzheimer's disease.

Gunasekaran, TI., et al.
2024,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Plasma miRNAs across the Alzheimer's disease continuum: Relationship to central biomarkers.

Liu, S., et al.
2024,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

The plasma miRNAome in ADNI: Signatures to aid the detection of at-risk individuals.

Krüger, DM., et al.
2024,  
Genome research

High-coverage nanopore sequencing of samples from the 1000 Genomes Project to build a comprehensive catalog of human genetic variation.

Gustafson, JA., et al.
2024,  
Nature communications

Genetic risk factors underlying white matter hyperintensities and cortical atrophy.

Patel, Y., et al.
2024,  
Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention

Adaptive Subtype and Stage Inference for Alzheimer's Disease.

Wang, X.
2024,  
Trends in immunology

New insights into innate immunity in Alzheimer's disease: from APOE protective variants to therapies.

Chen, Y.
2024,  
Immunological reviews

Current insights into apolipoprotein E and the immune response in Alzheimer's disease.

Lin, PB.
2024,  
bioRxiv : the preprint server for biology

Human-mouse proteomics reveals the shared pathways in Alzheimer's disease and delayed protein turnover in the amyloidome.

Yarbro, JM., et al.
2024,  
Heliyon

Brain-targeting liposome-based APOE2 gene delivery exacerbates soluble amyloid-β accumulation in App NL-G-F mice.

Wang, N., et al.
2024,  
Trends in molecular medicine

Does glial lipid dysregulation alter sleep in Alzheimer's and Parkinson's disease?

Goodman, LD., et al.
2024,  
Research square

Exploring Cellular Heterogeneity: Single-Cell and Spatial Transcriptomics of Alzheimer Disease Brains and iPSC-Derived Microglia.

Garg, A., et al.
2024,  
Human molecular genetics

Alzheimer's disease risk gene CD2AP is a dose-sensitive determinant of synaptic structure and plasticity.

Pavešković, M., et al.
2024,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Utility of cerebrovascular imaging biomarkers to detect cerebral amyloidosis.

Howe, MD., et al.
2024,  
Brain imaging and behavior

Multimodal nonlinear correlates of behavioural symptoms in frontotemporal dementia.

Zamboni, G., et al.
2024,  
Neurology

Gene-Specific Effects on Brain Volume and Cognition of TMEM106B in Frontotemporal Lobar Degeneration.

Vandebergh, M., et al.
2024,  
medRxiv : the preprint server for health sciences

Cross-Linguistic Analysis of Speech Markers: Insights from English, Chinese, and Italian Speakers.

Santi, GC., et al.
2024,  
Research square

DNA methylation age from peripheral blood predicts progression to Alzheimer's disease, white matter disease burden, and cortical atrophy.

Bonham, L., et al.
2024,  
Nature medicine

Brain aging patterns in a large and diverse cohort of 49,482 individuals.

Yang, Z., et al.
2024,  
Informatics for health & social care

Identifying biological markers and sociodemographic factors that influence the gap between phenotypic and chronological ages.

Pala, D., et al.
2024,  
Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention

Self-guided Knowledge-Injected Graph Neural Network for Alzheimer's Diseases.

Wang, Z., et al.
2024,  
Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention

Interpretable Spatio-Temporal Embedding for Brain Structural-Effective Network with Ordinary Differential Equation.

Tang, H., et al.
2024,  
Mathematics (Basel, Switzerland)

A Principled Framework to Assess the Information-Theoretic Fitness of Brain Functional Sub-Circuits.

Duong-Tran, D., et al.
2024,  
HGG advances

Enhancing personalized gene expression prediction from DNA sequences using genomic foundation models.

Ramprasad, P., et al.
2024,  
European heart journal

The AORTA Gene score for detection and risk stratification of ascending aortic dilation.

Pirruccello, JP., et al.
2024,  
JMIR aging

Assessment of Wearable Device Adherence for Monitoring Physical Activity in Older Adults: Pilot Cohort Study.

Ding, H., et al.
2024,  
Medical image analysis

Interpretable deep clustering survival machines for Alzheimer's disease subtype discovery.

Hou, B., et al.
2024,  
BioData mining

Assessing the limitations of relief-based algorithms in detecting higher-order interactions.

Freda, PJ., et al.
2024,  
BioData mining

Deep learning-based approaches for multi-omics data integration and analysis.

Ballard, JL., et al.
2024,  
BioData mining

PAGER: A novel genotype encoding strategy for modeling deviations from additivity in complex trait association studies.

Freda, PJ., et al.
2024,  
Research square

Genome wide association studies are enriched for interacting genes.

Nguyen, PT., et al.
2024,  
Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention

Volume-optimal persistence homological scaffolds of hemodynamic networks covary with MEG theta-alpha aperiodic dynamics.

Nguyen, N., et al.
2024,  
Current opinion in chemical biology

Neuroprotective signaling by hydrogen sulfide and its dysregulation in Alzheimer's disease.

Paul, BD.
2024,  
Nature biotechnology

A structurally informed human protein-protein interactome reveals proteome-wide perturbations caused by disease mutations.

Xiong, D., et al.
2024,  
Research square

A network-based systems genetics framework identifies pathobiology and drug repurposing in Parkinson's disease.

Dou, L., et al.
2024,  
Bioinformatics (Oxford, England)

GENEVIC: GENetic data Exploration and Visualization via Intelligent interactive Console.

Nath, A., et al.
2024,  
Journal of biomedical informatics

Clinical outcome-guided deep temporal clustering for disease progression subtyping.

Wang, D., et al.
2024,  
Genome research

Dynamic dysregulation of retrotransposons in neurodegenerative diseases at the single-cell level.

Deng, W., et al.
2024,  
The lancet. Healthy longevity

Biomarkers of neurodegeneration across the Global South.

McGlinchey, E., et al.
2024,  
bioRxiv : the preprint server for biology

Methylation Clocks Do Not Predict Age or Alzheimer's Disease Risk Across Genetically Admixed Individuals.

Cruz-González, S., et al.
2024,  
medRxiv : the preprint server for health sciences

Genome-wide scan of Flortaucipir PET levels finds JARID2 associated with cerebral tau deposition.

Gunasekaran, TI., et al.
2024,  
Cell

CSF proteomics identifies early changes in autosomal dominant Alzheimer's disease.

Shen, Y., et al.
2024,  
Research square

Polygenic proxies of age-related plasma protein levels reveal TIMP2 role in cognitive performance.

Anastasi, F., et al.
2024,  
bioRxiv : the preprint server for biology

Cytokine-induced reprogramming of human macrophages toward Alzheimer's disease-relevant molecular and cellular phenotypes in vitro.

Podlesny-Drabiniok, A., et al.
2024,  
Nature biotechnology

Detection of mosaic and population-level structural variants with Sniffles2.

Smolka, M., et al.
2024,  
bioRxiv : the preprint server for biology

An integrative systems-biology approach defines mechanisms of Alzheimer's disease neurodegeneration.

Leventhal, MJ., et al.
2024,  
Nature neuroscience

Tau is required for glial lipid droplet formation and resistance to neuronal oxidative stress.

Goodman, LD., et al.
2024,  
Acta neuropathologica

Hypothesis-based investigation of known AD risk variants reveals the genetic underpinnings of neuropathological lesions observed in Alzheimer's-type dementia.

Laureyssen, C., et al.
2024,  
bioRxiv : the preprint server for biology

Integrative Network Analysis Reveals Novel Moderators of Aβ-Tau Interaction in Alzheimer's Disease.

Kitani, A.
2024,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Cognitive resilience to Alzheimer's disease characterized by cell-type abundance.

O'Neill, N., et al.
2024,  
bioRxiv : the preprint server for biology

African origin haplotype protective for Alzheimer's disease in APOEε4 carriers: exploring potential mechanisms.

Bertholim-Nasciben, L., et al.
2024,  
Alzheimer's research & therapy

Blood-derived mitochondrial DNA copy number is associated with Alzheimer disease, Alzheimer-related biomarkers and serum metabolites.

Tong, T., et al.
2024,  
JAMA network open

Derivation of Indices of Cognitive Change Among Hispanic Adults and Elders.

Duff, K., et al.
2024,  
Science advances

Modeling Lewy body disease with SNCA triplication iPSC-derived cortical organoids and identifying therapeutic drugs.

Jin, Y., et al.
2024,  
Neuroscience

A transient brain endothelial translatome response to endotoxin is associated with mild cognitive changes post-shock in young mice.

Lu, S., et al.
2024,  
PLoS computational biology

pyPAGE: A framework for Addressing biases in gene-set enrichment analysis-A case study on Alzheimer's disease.

Bakulin, A., et al.
2024,  
Genetics in medicine : official journal of the American College of Medical Genetics

Dominant missense variants in SREBF2 are associated with complex dermatological, neurological, and skeletal abnormalities.

Moulton, MJ., et al.
2024,  
medRxiv : the preprint server for health sciences

Characterizing patterns of diffusion tensor imaging variance in aging brains.

Gao, C., et al.
2024,  
Magnetic resonance imaging

MidRISH: Unbiased harmonization of rotationally invariant harmonics of the diffusion signal.

Newlin, NR., et al.
2024,  
American journal of speech-language pathology

Applications of the R.A.I.S.E. Assessment Framework to Support the Process of Assessment in Primary Progressive Aphasia.

Gallée, J., et al.
2024,  
medRxiv : the preprint server for health sciences

Rethinking the residual approach: Leveraging machine learning to operationalize cognitive resilience in Alzheimer's disease.

Birkenbihl, C., et al.
2024,  
Cell reports. Medicine

The impact of multi-omics in medicine.

Wang, L., et al.
2024,  
Imaging neuroscience (Cambridge, Mass.)

Free-water: A promising structural biomarker for cognitive decline in aging and mild cognitive impairment.

Sathe, A., et al.
2024,  
Nature

Cellular communities reveal trajectories of brain ageing and Alzheimer's disease.

Green, GS., et al.
2024,  
bioRxiv : the preprint server for biology

gsQTL: Associating genetic risk variants with gene sets by exploiting their shared variability.

Bouland, GA., et al.
2024,  
The Lancet. Neurology

γ-Secretase activity, clinical features, and biomarkers of autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analysis of the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS).

Schultz, SA., et al.
2024,  
Journal of neurochemistry

The complexity of extracellular vesicles: Bridging the gap between cellular communication and neuropathology.

Tam, S., et al.
2024,  
ArXiv

Adapting Machine Learning Diagnostic Models to New Populations Using a Small Amount of Data: Results from Clinical Neuroscience.

Wang, R., et al.
2024,  
bioRxiv : the preprint server for biology

Comparison of Explainable AI Models for MRI-based Alzheimer's Disease Classification.

Chattopadhyay, T., et al.
2024,  
The annals of applied statistics

A bootstrap model comparison test for identifying genes with context-specific patterns of genetic regulation.

Malakhov, MM., et al.
2024,  
medRxiv : the preprint server for health sciences

Frequency of Variants in Mendelian Alzheimer's Disease Genes within the Alzheimer's Disease Sequencing Project (ADSP).

Wang, D., et al.
2024,  
American heart journal plus : cardiology research and practice

The association of exhaled carbon monoxide with atrial fibrillation and left atrial size in the Framingham Heart Study.

Eromosele, OB., et al.
2024,  
Research square

Assessing the Limitations of Relief-Based Algorithms in Detecting Higher-Order Interactions.

Freda, PJ., et al.
2024,  
medRxiv : the preprint server for health sciences

Language Modeling Screens Parkinson's Disease with Self-reported Questionnaires.

Reyes, DM., et al.
2024,  
Briefings in bioinformatics

A review of feature selection strategies utilizing graph data structures and Knowledge Graphs.

Shao, S., et al.
2024,  
medRxiv : the preprint server for health sciences

The Interaction Effects of Sex, Age, APOE and Common Health Risk Factors on Human Brain Functions.

Li, T., et al.
2024,  
Aging cell

An interpretable machine learning-based cerebrospinal fluid proteomics clock for predicting age reveals novel insights into brain aging.

Melendez, J., et al.
2024,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

A genetic and proteomic comparison of key AD biomarkers across tissues.

Marsh, TW., et al.
2024,  
Environmental health perspectives

Seminar: Functional Exposomics and Mechanisms of Toxicity-Insights from Model Systems and NAMs.

Lai, Y., et al.
2024,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference.

Kloske, CM., et al.
2024,  
Journal of biomedical informatics

Balancing the efforts of chart review and gains in PRS prediction accuracy: An empirical study.

Lei, Y., et al.
2024,  
Translational psychiatry

Chromosome X-wide association study in case control studies of pathologically confirmed Alzheimer's disease in a European population.

Simmonds, E., et al.
2024,  
Communications biology

AutoFocus: a hierarchical framework to explore multi-omic disease associations spanning multiple scales of biomolecular interaction.

Schweickart, A., et al.
2024,  
Nature communications

Genetic, transcriptomic, histological, and biochemical analysis of progressive supranuclear palsy implicates glial activation and novel risk genes.

Farrell, K., et al.
2024,  
Translational psychiatry

Causal relationships between dyslexia and the risk of eight dementias.

Zhu, P., et al.
2024,  
Nature communications

CYP1B1-RMDN2 Alzheimer's disease endophenotype locus identified for cerebral tau PET.

Nho, K., et al.
2024,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Admixture mapping of cognitive function in diverse Hispanic and Latino adults: Results from the Hispanic Community Health Study/Study of Latinos.

Xia, R., et al.
2024,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

A genome-wide association meta-analysis of all-cause and vascular dementia.

2024,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Leptin bioavailability and markers of brain atrophy and vascular injury in the middle age.

Charisis, S., et al.
2024,  
Communications biology

Genome-wide association study meta-analysis of neurofilament light (NfL) levels in blood reveals novel loci related to neurodegeneration.

Ahmad, S., et al.
2024,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Florbetaben amyloid PET acquisition time: Influence on Centiloids and interpretation.

Johns, E., et al.
2024,  
Brain, behavior, and immunity

Proteome-wide analysis identifies plasma immune regulators of amyloid-beta progression.

Duggan, MR., et al.
2024,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Spatial extent as a sensitive amyloid-PET metric in preclinical Alzheimer's disease.

Farrell, ME., et al.
2024,  
Scientific reports

Global perspectives on the management of primary progressive aphasia.

Gallée, J., et al.
2024,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

An ANXA11 P93S variant dysregulates TDP-43 and causes corticobasal syndrome.

Snyder, A., et al.
2024,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Assessing the lack of diversity in genetics research across neurodegenerative diseases: A systematic review of the GWAS Catalog and literature.

Jonson, C., et al.
2024,  
Research square

Variable and interactive effects of Sex, APOE

Giorgio, J., et al.
2024,  
medRxiv : the preprint server for health sciences

Country Level Incidence of Alzheimer Disease and Related Dementias is Associated with Increased Omega6 PUFA Consumption.

Ciesielski, TH., et al.
2024,  
bioRxiv : the preprint server for biology

Amyloid, Tau, and APOE in Alzheimer's Disease: Impact on White Matter Tracts.

Chandio, BQ., et al.
2024,  
American journal of human genetics

Inferring causal direction between two traits using R2 with application to transcriptome-wide association studies.

Liao, H., et al.
2024,  
Human molecular genetics

Whole genome sequencing based analysis of inflammation biomarkers in the Trans-Omics for Precision Medicine (TOPMed) consortium.

Jiang, M., et al.
2024,  
JMIR aging

Detection of Mild Cognitive Impairment From Non-Semantic, Acoustic Voice Features: The Framingham Heart Study.

Ding, H., et al.
2024,  
Annual review of biomedical data science

Centralized and Federated Models for the Analysis of Clinical Data.

Li, R., et al.
2024,  
Annual review of biomedical data science

Employing Informatics Strategies in Alzheimer's Disease Research: A Review from Genetics, Multiomics, and Biomarkers to Clinical Outcomes.

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medRxiv : the preprint server for health sciences

Connecting intermediate phenotypes to disease using multi-omics in heart failure.

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Single-nucleus multiome analysis of human cerebellum in Alzheimer's disease-related dementia.

Cheng, F., et al.
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Molecular psychiatry

Genetic overlap between Alzheimer's disease and immune-mediated diseases: an atlas of shared genetic determinants and biological convergence.

Enduru, N., et al.
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Single-nucleus multiomics reveals the disrupted regulatory programs in three brain regions of sporadic early-onset Alzheimer's disease.

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medRxiv : the preprint server for health sciences

Structural variants linked to Alzheimer's Disease and other common age-related clinical and neuropathologic traits.

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Scupa: Single-cell unified polarization assessment of immune cells using the single-cell foundation model.

Liu, W.
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medRxiv : the preprint server for health sciences

Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries.

García-Marín, LM., et al.
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Region-based analysis with functional annotation identifies genes associated with cognitive function in South Asians from India.

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Acta neuropathologica

Epigenetic and genetic risk of Alzheimer disease from autopsied brains in two ethnic groups.

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Nature communications

SR-TWAS: leveraging multiple reference panels to improve transcriptome-wide association study power by ensemble machine learning.

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BLEND: Probabilistic Cellular Deconvolution with Automated Reference Selection.

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Molecular neurodegeneration

Whole-genome sequencing analysis reveals new susceptibility loci and structural variants associated with progressive supranuclear palsy.

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Alzheimer's & dementia : the journal of the Alzheimer's Association

Extended genome-wide association study employing the African genome resources panel identifies novel susceptibility loci for Alzheimer's disease in individuals of African ancestry.

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Brain, behavior, & immunity - health

Associations between IL-1β, IL-6, and TNFα polymorphisms and longitudinal trajectories of cognitive function in non-demented older adults.

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Alzheimer's & dementia : the journal of the Alzheimer's Association

Revised criteria for diagnosis and staging of Alzheimer's disease: Alzheimer's Association Workgroup.

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Nature medicine

Revised criteria for the diagnosis and staging of Alzheimer's disease.

Jack, CR., et al.
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Alzheimer's & dementia : the journal of the Alzheimer's Association

Sex and gender differences in cognitive resilience to aging and Alzheimer's disease.

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Neuron

Therapeutic potential of human microglia transplantation in a chimeric model of CSF1R-related leukoencephalopathy.

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Hormones and behavior

Treatment with brain specific estrogen prodrug ameliorates cognitive effects of surgical menopause in mice.

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medRxiv : the preprint server for health sciences

Alzheimer's disease protective allele of Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication.

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Pancreatic cancer organoid-screening captures personalized sensitivity and chemoresistance suppression upon cytochrome P450 3A5-targeted inhibition.

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Secretome from iPSC-derived MSCs exerts proangiogenic and immunosuppressive effects to alleviate radiation-induced vascular endothelial cell damage.

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Blood-Based Proteomics for Adult-Onset Focal Dystonias.

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Temporal tau asymmetry spectrum influences divergent behavior and language patterns in Alzheimer's disease.

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Identifying longitudinal cognitive resilience from cross-sectional amyloid, tau, and neurodegeneration.

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Journal of medical imaging (Bellingham, Wash.)

Characterizing patterns of diffusion tensor imaging variance in aging brains.

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Biological psychiatry

A Single-Nucleus Transcriptome-Wide Association Study Implicates Novel Genes in Depression Pathogenesis.

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Evaluating the Effect of Alzheimer's Disease-Related Biomarker Change in Corticobasal Syndrome and Progressive Supranuclear Palsy.

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Alzheimer's & dementia : the journal of the Alzheimer's Association

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Dementia Prevalence and Onchocerca volvulus Infection among Rural Elderly Persons in the Ntui Health District, Cameroon: A Population-Based Study.

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medRxiv : the preprint server for health sciences

AD plasma biomarkers are stable for an extended period at -20°C: implications for resource-constrained environments.

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A principled framework to assess the information-theoretic fitness of brain functional sub-circuits.

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JMIR biomedical engineering

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Identification of Parkinson's disease PACE subtypes and repurposing treatments through integrative analyses of multimodal data.

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GRPa-PRS: A risk stratification method to identify genetically-regulated pathways in polygenic diseases.

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HGG advances

DeepFace: Deep-learning-based framework to contextualize orofacial-cleft-related variants during human embryonic craniofacial development.

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A Comprehensive Head-to-Head Comparison of Key Plasma Phosphorylated Tau 217 Biomarker Tests.

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Alzheimer's & dementia : the journal of the Alzheimer's Association

Considerations for the use of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) in cross-country comparisons of cognitive aging and dementia.

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Alzheimer's & dementia : the journal of the Alzheimer's Association

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A Specialized Reference Panel with Structural Variants Integration for Improving Genotype Imputation in Alzheimer's Disease and Related Dementias (ADRD).

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Alzheimer's & dementia : the journal of the Alzheimer's Association

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Midkine Attenuates Aβ Fibril Assembly and AmyloidPlaque Formation.

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Prevalence of and Annual Conversion Rates to Mild Cognitive Impairment and Dementia: Prospective, Longitudinal Study of an Essential Tremor Cohort.

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Alzheimer's & dementia : the journal of the Alzheimer's Association

α-Synuclein seed amplification assay detects Lewy body co-pathology in autosomal dominant Alzheimer's disease late in the disease course and dependent on Lewy pathology burden.

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Bioinformatics (Oxford, England)

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bioRxiv : the preprint server for biology

Single-nucleus multiomics reveals the disrupted regulatory programs in three brain regions of sporadic early-onset Alzheimer's disease.

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Annals of statistics

ON BLOCKWISE AND REFERENCE PANEL-BASED ESTIMATORS FOR GENETIC DATA PREDICTION IN HIGH DIMENSIONS.

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medRxiv : the preprint server for health sciences

Benchmarking of a multi-biomarker low-volume panel for Alzheimer's Disease and related dementia research.

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Nature communications

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2024,  
bioRxiv : the preprint server for biology

Sex, racial, and APOE-ε4 allele differences in longitudinal white matter microstructure in multiple cohorts of aging and Alzheimer's disease.

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Alzheimer's & dementia : the journal of the Alzheimer's Association

Metabolomics profiling reveals distinct, sex-specific signatures in serum and brain metabolomes in mouse models of Alzheimer's disease.

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Novel early-onset Alzheimer-associated genes influence risk through dysregulation of glutamate, immune activation, and intracell signaling pathways.

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The neuroradiology journal

Association of brain arterial diameters with demographic and anatomical factors in a multi-national pooled analysis of cohort studies.

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Alzheimer's & dementia : the journal of the Alzheimer's Association

The 2022 symposium on dementia and brain aging in low- and middle-income countries: Highlights on research, diagnosis, care, and impact.

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Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Neurotoxic Microglial Activation via IFNγ-Induced Nrf2 Reduction Exacerbating Alzheimer's Disease.

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bioRxiv : the preprint server for biology

regionalpcs: improved discovery of DNA methylation associations with complex traits.

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A transient brain endothelial translatome response to endotoxin is associated with mild cognitive changes post-shock in young mice.

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The Lancet. Neurology

Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer's disease: a cross-sectional study.

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JAMA psychiatry

Genetic and Clinical Correlates of AI-Based Brain Aging Patterns in Cognitively Unimpaired Individuals.

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Journal of translational medicine

Deep learning imaging phenotype can classify metabolic syndrome and is predictive of cardiometabolic disorders.

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bioRxiv : the preprint server for biology

Automated Cytometric Gating with Human-Level Performance Using Bivariate Segmentation.

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LRRK2 G2019S variant is associated with transcriptional changes in Parkinson's disease human myeloid cells under proinflammatory environment.

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Generalizing Parkinson's disease detection using keystroke dynamics: a self-supervised approach.

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PLoS genetics

iGWAS: Image-based genome-wide association of self-supervised deep phenotyping of retina fundus images.

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Proceedings of machine learning research

Online Bilevel Optimization: Regret Analysis of Online Alternating Gradient Methods.

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MAPPING ALZHEIMER'S DISEASE PSEUDO-PROGRESSION WITH MULTIMODAL BIOMARKER TRAJECTORY EMBEDDINGS.

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MULTISCALE ESTIMATION OF MORPHOMETRICITY FOR REVEALING NEUROANATOMICAL BASIS OF COGNITIVE TRAITS.

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Cell reports

Systematic characterization of multi-omics landscape between gut microbial metabolites and GPCRome in Alzheimer's disease.

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Montelukast as a repurposable additive drug for standard-efficacy multiple sclerosis treatment: Emulating clinical trials with retrospective administrative health claims data.

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Plasma Leptin and Alzheimer Protein Pathologies Among Older Adults.

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Alzheimer's & dementia : the journal of the Alzheimer's Association

Key variants via the Alzheimer's Disease Sequencing Project whole genome sequence data.

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medRxiv : the preprint server for health sciences

SR-TWAS: Leveraging Multiple Reference Panels to Improve TWAS Power by Ensemble Machine Learning.

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Communications biology

Supervised latent factor modeling isolates cell-type-specific transcriptomic modules that underlie Alzheimer's disease progression.

Hodgson, L., et al.
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Science advances

Brain cell-type shifts in Alzheimer's disease, autism, and schizophrenia interrogated using methylomics and genetics.

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eLife

Biobank-wide association scan identifies risk factors for late-onset Alzheimer's disease and endophenotypes.

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Briefings in bioinformatics

CWAS-Plus: estimating category-wide association of rare noncoding variation from whole-genome sequencing data with cell-type-specific functional data.

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Nature communications

Validation of human telomere length multi-ancestry meta-analysis association signals identifies POP5 and KBTBD6 as human telomere length regulation genes.

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Cell reports. Medicine

Genetic variants for head size share genes and pathways with cancer.

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Life science alliance

A comparative study of structural variant calling in WGS from Alzheimer's disease families.

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Human brain mapping

Diffusion MRI harmonization via personalized template mapping.

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Neuron

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The Journal of experimental medicine

Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy.

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Profiling Protein-Protein Interactions in the Human Brain by Refined Cofractionation Mass Spectrometry.

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PLoS biology

Brain high-throughput multi-omics data reveal molecular heterogeneity in Alzheimer's disease.

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Nature neuroscience

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Neuroinformatics

DeepN4: Learning N4ITK Bias Field Correction for T1-weighted Images.

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Alzheimer's & dementia : the journal of the Alzheimer's Association

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Sleep medicine

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Alzheimer's & dementia : the journal of the Alzheimer's Association

More than a piece of cake: Noun classifier processing in primary progressive aphasia.

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Data stewardship in FTLD research: Investigator and research participant views.

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Biostatistics (Oxford, England)

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TOPMed imputed genomics enhances genomic atlas of the human proteome in brain, cerebrospinal fluid, and plasma.

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CWAS-Plus: Estimating category-wide association of rare noncoding variation from whole-genome sequencing data with cell-type-specific functional data.

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Alzheimer's & dementia : the journal of the Alzheimer's Association

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Acta neuropathologica

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The Role of X Chromosome in Alzheimer's Disease Genetics.

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Mining the Metabolic Capacity of Clostridium sporogenes Aided by Machine Learning.

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Network medicine informed multi-omics integration identifies drug targets and repurposable medicines for Amyotrophic Lateral Sclerosis.

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