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2025

2025,  
Sleep medicine

Exploring nightly variability and clinical influences on sleep measures: insights from a digital brain health platform.

Ding, H., et al.
2025,  
Sleep medicine

Exploring nightly variability and clinical influences on sleep measures: insights from a digital brain health platform.

Ding, H., et al.
2025,  
Sleep medicine

Exploring nightly variability and clinical influences on sleep measures: insights from a digital brain health platform.

Ding, H., et al.
2025,  
Sleep medicine

Exploring nightly variability and clinical influences on sleep measures: insights from a digital brain health platform.

Ding, H., et al.
2025,  
Sleep medicine

Exploring nightly variability and clinical influences on sleep measures: insights from a digital brain health platform.

Ding, H., et al.
2025,  
Sleep medicine

Exploring nightly variability and clinical influences on sleep measures: insights from a digital brain health platform.

Ding, H., et al.
2025,  
Alzheimer disease and associated disorders

Asian Cohort for Alzheimer Disease (ACAD) Pilot Study: Vietnamese Americans.

Peavy, GM., et al.
2025,  
Alzheimer disease and associated disorders

Visuospatial and Verbal Memory Differences in Amish Individuals With Alzheimer Disease and Related Dementias.

Prough, MB., et al.
2025,  
Alzheimer disease and associated disorders

Clinical Profiles of Arteriolosclerosis and Alzheimer Disease at Mild Cognitive Impairment and Mild Dementia in a National Neuropathology Cohort.

Yang, D.
2025,  
Alzheimer disease and associated disorders

A Novel Method for Establishing Functional Change in Older Adults With Cognitive Impairment.

González, DA., et al.
2025,  
Journal of the American Society of Nephrology : JASN

Uremic Toxins, CKD, and Cognitive Dysfunction.

Andrews, TD., et al.
2025,  
Nature human behaviour

Charting brain functional development from birth to 6 years of age.

Yin, W., et al.
2025,  
Annals of neurology

The Use of Antihypertensive Medication and In Vivo Alzheimer's Disease Pathology.

Keum, M., et al.
2025,  
Molecular psychiatry

X-chromosome-wide association study for Alzheimer's disease.

Le Borgne, J., et al.
2025,  
Glia

Contributions of Genetic Variation in Astrocytes to Cell and Molecular Mechanisms of Risk and Resilience to Late-Onset Alzheimer's Disease.

Lee, H., et al.
2025,  
The journals of gerontology. Series B, Psychological sciences and social sciences

Understanding the Stress Process Among Mexican American Adults Aged 50 and Older in the United States.

Muñoz, E., et al.
2025,  
Acta neuropathologica communications

Age-dependent interactions of APOE isoform 4 and Alzheimer's disease neuropathology: findings from the NACC.

Hayes, CA., et al.
2025,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Sleep macro-architecture, nocturnal hypoxemia, and Alzheimer's disease-related MRI patterns among diverse older adults.

Liu, DX., et al.
2025,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Racial ethnic variations in the cardiometabolic determinants and blood pressure of white matter hyperintensities among females-The HABS-HD Study.

Hayes, CA., et al.
2025,  
medRxiv : the preprint server for health sciences

Identification and Validation of New Molecular Subtypes within the Early and Late Mild Cognitive Impairment Stages of Alzheimer's Disease.

Li, B., et al.
2025,  
The Clinical neuropsychologist

Health insurance coverage moderates the relationship between metabolic syndrome and baseline memory outcomes in Latino older adults.

Breton, J., et al.
2025,  
medRxiv : the preprint server for health sciences

Mediating effect of pro-inflammatory cytokines in the association between depression, anxiety, and cardiometabolic disorders in an ethnically diverse community-dwelling middle-aged and older US population.

Hallab, A.
2025,  
medRxiv : the preprint server for health sciences

Mediating role of Interleukin-6 in the predictive association of diabetes with Hippocampus atrophy, Amyloid, Tau, and Neurofilament pathology at pre-clinical stages of diabetes-related cognitive impairment.

Hallab, A.
2025,  
Nature genetics

CHOIR improves significance-based detection of cell types and states from single-cell data.

Sant, C., et al.
2025,  
Neuron

Multi-cohort cerebrospinal fluid proteomics identifies robust molecular signatures across the Alzheimer disease continuum.

Ali, M., et al.
2025,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Ubiquitin-proteasome system in the different stages of dominantly inherited Alzheimer's disease.

Liu, H., et al.
2025,  
Molecular neurodegeneration

Alzheimer's disease protective allele of Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication.

Zhao, X., et al.
2025,  
Research square

Genetic Contributions to Alzheimer's Disease and Frontotemporal Dementia in Admixed Latin American Populations.

Acosta-Uribe, J., et al.
2025,  
medRxiv : the preprint server for health sciences

Interpretable MRI-Based Deep Learning for Alzheimer's Risk and Progression.

Lu, B., et al.
2025,  
BioData mining

Network-based analyses of multiomics data in biomedicine.

Kumar, R., et al.
2025,  
medRxiv : the preprint server for health sciences

Bayesian inference of genetic pleiotropy identifies drug targets and repurposable medicines for human complex diseases.

Lorincz-Comi, N.
2025,  
Proceedings of the National Academy of Sciences of the United States of America

Inhibiting 15-PGDH blocks blood-brain barrier deterioration and protects mice from Alzheimer's disease and traumatic brain injury.

Koh, Y., et al.
2025,  
medRxiv : the preprint server for health sciences

D3MI: an efficient and powerful federated imputation method for bias reduction in the analysis of distributed incomplete data by accounting for within-site correlation and between-site heterogeneity.

Lian, Y., et al.
2025,  
International journal of molecular sciences

Genetic, Transcriptomic, and Epigenomic Insights into Sjögren's Disease: An Integrative Network Investigation and Immune Diseases Comparison.

Enduru, N., et al.
2025,  
Briefings in bioinformatics

iGTP: learning interpretable cellular embedding for inferring biological mechanisms underlying single-cell transcriptomics.

Hsieh, K., et al.
2025,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Insights into pathophysiology, biomarkers, and therapeutics in tauopathies: Proceedings of the Tau2024 Global Conference.

Frost, B., et al.
2025,  
Journal of neurology, neurosurgery, and psychiatry

Telomere length, in vivo Alzheimer's disease pathologies and cognitive decline in older adults.

Jung, JH., et al.
2025,  
Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology

The Effect of Cholinesterase Inhibitors on Neurodegeneration in Individuals with Amnestic Mild Cognitive Impairment.

Byeon, G., et al.
2025,  
Communications biology

Leveraging multivariate information for community detection in functional brain networks.

Puxeddu, MG., et al.
2025,  
Nature medicine

A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer's disease.

Oh, HS., et al.
2025,  
The journal of prevention of Alzheimer's disease

Association of dietary fatty acids with longitudinal change in plasma-based biomarkers of Alzheimer's disease.

Hoost, SS., et al.
2025,  
medRxiv : the preprint server for health sciences

Heritability of Alzheimer-related plasma biomarkers in the Amish population.

Wang, P., et al.
2025,  
Nature communications

An integrative systems-biology approach defines mechanisms of Alzheimer's disease neurodegeneration.

Leventhal, MJ., et al.
2025,  
Movement disorders : official journal of the Movement Disorder Society

Copy Number Variation and Haplotype Analysis of 17q21.31 Reveals Increased Risk Associated with Progressive Supranuclear Palsy and Gene Expression Changes in Neuronal Cells.

Wang, H., et al.
2025,  
medRxiv : the preprint server for health sciences

Multi-population Genome-Wide Association Study Identifies Multiple Novel Loci associated with Asymptomatic Intracranial Large Artery Stenosis.

Liu, M., et al.
2025,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Alzheimer's Disease Sequencing Project release 4 whole genome sequencing dataset.

Leung, YY., et al.
2025,  
bioRxiv : the preprint server for biology

Sequencing the gaps: dark genomic regions persist in CHM13 despite long-read advances.

Wadsworth, ME., et al.
2025,  
Journal of Alzheimer's disease : JAD

Association of Alzheimer's disease biomarkers with low premorbid intellectual functioning in a multi-ethnic community-dwelling cohort: A cross-sectional study of HABS-HD.

Abdullah, L., et al.
2025,  
Proceedings. IEEE International Symposium on Biomedical Imaging

AUTOENCODER FOR 4-DIMENSIONAL FIBER ORIENTATION DISTRIBUTIONS FROM DIFFUSION MRI.

Huang, S., et al.
2025,  
medRxiv : the preprint server for health sciences

Chronic emotional stress and mediating role of Interleukine-6 in the association with cardiometabolic disorders in a multiethnic middle-aged and older US-population.

Hallab, A.
2025,  
medRxiv : the preprint server for health sciences

Mediating effect of pro-inflammatory cytokines in the association between depression, anxiety, and cardiometabolic disorders in an ethnically diverse middle-aged and older population.

Hallab, A.
2025,  
Cell

Turnover atlas of proteome and phosphoproteome across mouse tissues and brain regions.

Li, W., et al.
2025,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Somatic and Stem Cell Bank to study the contribution of African ancestry to dementia: African iPSC Initiative.

Maina, MB., et al.
2025,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Genome-wide association analysis identifies APOE as a mitophagy modifier in Lewy body disease.

Hou, X., et al.
2025,  
Genome research

Integration of transcriptomics and long-read genomics prioritizes structural variants in rare disease.

Jensen, TD., et al.
2025,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Addressing overfitting bias due to sample overlap in polygenic risk scoring.

Jeong, S., et al.
2025,  
Human brain mapping

MRI Distance Measures as a Predictor of Subsequent Clinical Status During the Preclinical Phase of Alzheimer's Disease and Related Disorders.

Zhang, X., et al.
2025,  
PLoS genetics

Enhancing nonlinear transcriptome- and proteome-wide association studies via trait imputation with applications to Alzheimer's disease.

He, R., et al.
2025,  
Nature genetics

Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes.

Henry, A., et al.
2025,  
Scientific reports

Association of the digital clock drawing test with amyloid and tau PET biomarkers in low age risk adults.

Ding, H., et al.
2025,  
Nature communications

A genetically informed brain atlas for enhancing brain imaging genomics.

Bao, J., et al.
2025,  
BioData mining

Enhancing clinical outcome predictions through effective sample size evaluation in graph-based digital twin modeling.

Li, X., et al.
2025,  
ArXiv

Knowledge-Driven Feature Selection and Engineering for Genotype Data with Large Language Models.

Lee, J., et al.
2025,  
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Utilization of precision medicine digital twins for drug discovery in Alzheimer's disease.

Ren, Y., et al.
2025,  
Scientific reports

A pioneering artificial intelligence tool to predict treatment outcomes in ovarian cancer via diagnostic laparoscopy.

Ma, X., et al.
2025,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

APOE and Alzheimer's disease and related dementias risk among 12,221 Hispanics/Latinos.

Barral, S., et al.
2025,  
medRxiv : the preprint server for health sciences

Alzheimer disease is (sometimes) highly heritable: Drivers of variation in heritability estimates for binary traits, a systematic review.

Liu, S., et al.
2025,  
Alzheimer's research & therapy

Integrative network analysis reveals novel moderators of Aβ-Tau interaction in Alzheimer's disease.

Kitani, A.
2025,  
Acta neuropathologica

LATE-NC Stage 3: a diagnostic rubric to differentiate severe LATE-NC from FTLD-TDP.

Shahidehpour, RK., et al.
2025,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Long sleep duration, cognitive performance, and the moderating role of depression: A cross-sectional analysis in the Framingham Heart Study.

Young, VM., et al.
2025,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Elevated serum cortisol associated with early-detected increase of brain amyloid deposition in Alzheimer's disease imaging biomarkers among menopausal women: The Framingham Heart Study.

Salardini, A., et al.
2025,  
Neurology. Genetics

Whole Genome Variable Number Tandem Repeat Analysis in Alzheimer Disease.

Heath, A., et al.
2025,  
Nature genetics

Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing.

Humphrey, J., et al.
2025,  
medRxiv : the preprint server for health sciences

SingleBrain: A Meta-Analysis of Single-Nucleus eQTLs Linking Genetic Risk to Brain Disorders.

Jang, B., et al.
2025,  
bioRxiv : the preprint server for biology

Cytosine-to-uracil RNA editing is upregulated by pro-inflammatory stimulation of myeloid cells.

Seo, H., et al.
2025,  
Journal of the American Geriatrics Society

Design and methodology of the harmonized diagnostic assessment of dementia for the longitudinal aging study in India: Wave 2.

Khobragade, PY., et al.
2025,  
Neuropsychology

The association of multilingualism with diverse language families and cognition among adults with and without education in India.

Petrosyan, S., et al.
2025,  
Nature biotechnology

Analysis and benchmarking of small and large genomic variants across tandem repeats.

English, AC., et al.
2025,  
Nature genetics

Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk.

Choi, SH., et al.
2025,  
Journal of neurology, neurosurgery, and psychiatry

Genetics impact risk of Alzheimer's disease through mechanisms modulating structural brain morphology in late life.

Korologou-Linden, R., et al.
2025,  
International journal of molecular sciences

Differential Transcriptional Programs Reveal Modular Network Rearrangements Associated with Late-Onset Alzheimer's Disease.

Pérez-González, AP., et al.
2025,  
medRxiv : the preprint server for health sciences

Leveraging multimodal neuroimaging and GWAS for identifying modality-level causal pathways to Alzheimer's disease.

Tian, Y., et al.
2025,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Distinct medical and substance use histories associate with cognitive decline in Alzheimer's disease.

Mansel, C., et al.
2025,  
Research square

Sex-specific Associations of Gene Expression with Alzheimer's Disease Neuropathology and Ante-mortem Cognitive Performance.

Dumitrescu, L., et al.
2025,  
PLoS genetics

Local genetic covariance analysis with lipid traits identifies novel loci for early-onset Alzheimer's Disease.

Ray, NR., et al.
2025,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Generalizability of tau and amyloid plasma biomarkers in Alzheimer's disease cohorts of diverse genetic ancestries.

Griswold, AJ., et al.
2025,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Chronic stress, social support, and Alzheimer's blood-based biomarkers in the HABS-HD study.

Lee, JK., et al.
2025,  
medRxiv : the preprint server for health sciences

Objective Sleep Quality in Diverse Older Adults: the Importance of Race and Ethnicity and Sex.

Cavaillès, C., et al.
2025,  
Neurobiology of disease

Alzheimer's disease risk ABCA7 p.A696S variant disturbs the microglial response to amyloid pathology in mice.

Ma, X., et al.
2025,  
bioRxiv : the preprint server for biology

Therapeutic assessment of a novel mitochondrial complex I inhibitor in in vitro and in vivo models of Alzheimer's disease.

Trushin, S., et al.
2025,  
Neuron

The night's watch: Exploring how sleep protects against neurodegeneration.

Parhizkar, S.
2025,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Neuronal ABCA7 deficiency aggravates mitochondrial dysfunction and neurodegeneration in Alzheimer's disease.

Wang, N., et al.
2025,  
bioRxiv : the preprint server for biology

Midkine Attenuates Aβ Fibril Assembly and Amyloid Plaque Formation.

Zaman, M., et al.
2025,  
Neuron

CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions.

Li, E., et al.
2025,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Interactions between menopause and high-fat diet on cognition and pathology in a mouse model of Alzheimer's disease.

Abi-Ghanem, C., et al.
2025,  
NPJ Parkinson's disease

Longitudinal multi-omics in alpha-synuclein Drosophila model discriminates disease- from age-associated pathologies in Parkinson's disease.

Moore, J., et al.
2025,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

The impact of arteriolosclerosis on cognitive impairment in decedents without severe dementia from the National Alzheimer's Coordinating Center.

Hayes, CA., et al.
2025,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Amyloid PET predicts longitudinal functional and cognitive trajectories in a heterogeneous cohort.

Younes, K., et al.
2025,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Plasma protein risk scores for mild cognitive impairment and Alzheimer's disease in the Framingham heart study.

Rehman, H., et al.
2025,  
Neural networks : the official journal of the International Neural Network Society

BPEN: Brain Posterior Evidential Network for trustworthy brain imaging analysis.

Ye, K., et al.
2025,  
BioData mining

High-dimensional mediation analysis reveals the mediating role of physical activity patterns in genetic pathways leading to AD-like brain atrophy.

Xu, H., et al.
2025,  
Communications biology

Longitudinal excitation-inhibition balance altered by sex and APOE-ε4.

Burns, AP., et al.
2025,  
medRxiv : the preprint server for health sciences

Leveraging functional annotations to map rare variants associated with Alzheimer's disease with gruyere.

Das, A., et al.
2025,  
medRxiv : the preprint server for health sciences

Vision Transformer Autoencoders for Unsupervised Representation Learning: Capturing Local and Non-Local Features in Brain Imaging to Reveal Genetic Associations.

Islam, SR., et al.
2025,  
Human genetics

Assessing the predicted impact of single amino acid substitutions in calmodulin for CAGI6 challenges.

Turina, P., et al.
2025,  
Human genetics

Assessing the predicted impact of single amino acid substitutions in MAPK proteins for CAGI6 challenges.

Turina, P., et al.
2025,  
Human genetics

Evaluation of enzyme activity predictions for variants of unknown significance in Arylsulfatase A.

Jain, S., et al.
2025,  
The Journal of clinical endocrinology and metabolism

Defining Continuous Glucose Monitor Time in Range in a Large, Community-Based Cohort Without Diabetes.

Spartano, NL., et al.
2025,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Dynamic lifetime risk prediction of Alzheimer's disease with longitudinal cognitive assessment measurements.

Ding, H., et al.
2025,  
JMIR formative research

Digital Assessment of Cognitive Health in Outpatient Primary Care: Usability Study.

Doerr, AJ., et al.
2025,  
Bioinformatics (Oxford, England)

Rethinking GWAS: how lessons from genetic screens and artificial intelligence could reveal biological mechanisms.

Hazelett, DJ.
2025,  
Bioinformatics (Oxford, England)

Predicting explainable dementia types with LLM-aided feature engineering.

Kashyap, AM., et al.
2025,  
PLoS medicine

Efficacy and safety of passive immunotherapies targeting amyloid beta in Alzheimer's disease: A systematic review and meta-analysis.

Tonegawa-Kuji, R., et al.
2025,  
Genome medicine

Structural variants linked to Alzheimer's disease and other common age-related clinical and neuropathologic traits.

Vialle, RA., et al.
2025,  
Stroke

Socioeconomic Status and Stroke: A Review of the Latest Evidence on Inequalities and Their Drivers.

Pantoja-Ruiz, C., et al.
2025,  
medRxiv : the preprint server for health sciences

Genetic Regulation of the Metabolome Differs by Sex, Alzheimer's Disease Stage, and Plasma Biomarker Status.

Eissman, JM., et al.
2025,  
eNeuro

Detection of Mitotic Neuroblasts Provides Additional Evidence of Steady-State Neurogenesis in the Adult Small Intestinal Myenteric Plexus.

Gorecki, AM., et al.
2025,  
Journal of neurotrauma

Traumatic Brain Injury and Alzheimer's Disease Biomarkers: A Systematic Review of Findings from Amyloid and Tau Positron Emission Tomography.

Dybing, KM., et al.
2025,  
Journal of Alzheimer's disease : JAD

Daily fluid intake and brain amyloid deposition: A cohort study.

Kim, JW., et al.
2025,  
Research square

Large-scale Plasma Proteomic Profiling Unveils Novel Diagnostic Biomarkers and Pathways for Alzheimer's Disease.

Cruchaga, C., et al.
2025,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Considerations in the clinical use of amyloid PET and CSF biomarkers for Alzheimer's disease.

Leuzy, A., et al.
2025,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Preclinical Alzheimer's disease shows alterations in circulating neuronal-derived extracellular vesicle microRNAs in a multiethnic cohort.

Reho, P., et al.
2025,  
Journal of the American Geriatrics Society

Neighborhoods, Networks, and Neurodegeneration: A Call for Population-Level Policy and Advancing the Exposome.

Babulal, GM.
2025,  
Human brain mapping

Cross-Sectional Comparison of Structural MRI Markers of Impairment in a Diverse Cohort of Older Adults.

Wisch, JK., et al.
2025,  
Nature communications

Human and mouse proteomics reveals the shared pathways in Alzheimer's disease and delayed protein turnover in the amyloidome.

Yarbro, JM., et al.
2025,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Role of tau versus TDP-43 pathology on medial temporal lobe atrophy in aging and Alzheimer's disease.

Wisse, LEM., et al.
2025,  
bioRxiv : the preprint server for biology

CHOIR improves significance-based detection of cell types and states from single-cell data.

Sant, C., et al.
2025,  
Human brain mapping

Head Motion in Diffusion Magnetic Resonance Imaging: Quantification, Mitigation, and Structural Associations in Large, Cross-Sectional Datasets Across the Lifespan.

Schilling, KG., et al.
2025,  
Nature communications

Automated cytometric gating with human-level performance using bivariate segmentation.

Chen, J., et al.
2025,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Functional insight into East Asian-specific genetic risk loci for Alzheimer's disease.

Cho, M., et al.
2025,  
bioRxiv : the preprint server for biology

Synthetic Diffusion Tensor Imaging Maps Generated by 2D and 3D Probabilistic Diffusion Models: Evaluation and Applications.

Chattopadhyay, T., et al.
2025,  
Cancers

Advancing Pancreatic Cancer Prediction with a Next Visit Token Prediction Head on Top of Med-BERT.

He, J., et al.
2025,  
Journal of diabetes science and technology

Expert Clinical Interpretation of Continuous Glucose Monitor Reports From Individuals Without Diabetes.

Spartano, NL., et al.
2025,  
Bioinformatics (Oxford, England)

ESCARGOT: an AI agent leveraging large language models, dynamic graph of thoughts, and biomedical knowledge graphs for enhanced reasoning.

Matsumoto, N., et al.
2025,  
Nature communications

Drug repurposing for Alzheimer's disease and other neurodegenerative disorders.

Cummings, JL., et al.
2025,  
bioRxiv : the preprint server for biology

Gene module-trait network analysis uncovers cell type specific systems and genes relevant to Alzheimer's Disease.

de Paiva Lopes, K., et al.
2025,  
medRxiv : the preprint server for health sciences

A Novel Method to Disentangle Tightly Linked Risk and Resilience Genes for Brain Disorders: Application to Alzheimer's Disease.

Barnett, EJ., et al.
2025,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Tau pathway-based gene analysis on PET identifies CLU and FYN in a Korean cohort.

Yi, D., et al.
2025,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Locus coeruleus tau is linked to successive cortical tau accumulation.

Yi, D., et al.
2025,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Transcriptome analysis of early- and late-onset Alzheimer's disease in Korean cohorts.

Han, S., et al.
2025,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Moderation of midlife cognitive activity on tau-related cognitive impairment.

Ko, K., et al.
2025,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Benchmarking of a multi-biomarker low-volume panel for Alzheimer's disease and related dementia research.

Ibanez, L., et al.
2025,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

The association between adult child education and cognitive functioning among older parents: A cross-national comparison of diverse contexts.

Nichols, E., et al.
2025,  
Nature communications

Long-read sequencing of 945 Han individuals identifies structural variants associated with phenotypic diversity and disease susceptibility.

Gong, J., et al.
2025,  
Scientific reports

Association of genetic risk of Alzheimer's disease and cognitive function in two European populations.

Wang, B., et al.
2025,  
Brain : a journal of neurology

Amyloid-β predominant Alzheimer's disease neuropathologic change.

Kovacs, GG., et al.
2025,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Association of APOE alleles and polygenic profiles comprising APOE-TOMM40-APOC1 variants with Alzheimer's disease neuroimaging markers.

Kulminski, AM., et al.
2025,  
medRxiv : the preprint server for health sciences

GWAS links APOE to neuropsychiatric symptoms in mild cognitive impairment and dementia.

Vattathil, SM., et al.
2025,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Human herpesvirus-associated transposable element activation in human aging brains with Alzheimer's disease.

Feng, Y., et al.
2025,  
Nature communications

Individual bioenergetic capacity as a potential source of resilience to Alzheimer's disease.

Arnold, M., et al.
2025,  
bioRxiv : the preprint server for biology

BTS: scalable Bayesian Tissue Score for prioritizing GWAS variants and their functional contexts across omics data.

Kuksa, PP., et al.
2025,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Comparing Alzheimer's genes in African, European, and Amerindian induced pluripotent stem cell-derived microglia.

Moura, S., et al.
2025,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Plasma proteomic characterization of motoric cognitive risk and mild cognitive impairment.

Gomez, GT., et al.
2025,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Blood biomarkers in Down syndrome: Facilitating Alzheimer's disease detection and monitoring.

Petersen, ME., et al.
2025,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Differential associations of neighborhood disadvantage, race/ethnicity, and cognitive status with experiences of psychosocial distress in the HABS-HD cohort.

Rhoads, T., et al.
2025,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Alzheimer's disease plasma biomarkers and physical functioning in a diverse sample of adults.

Knell, G., et al.
2025,  
Cell

Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes.

Guo, JL., et al.
2025,  
medRxiv : the preprint server for health sciences

Somatic and Stem Cell Bank to Study the Contribution of African Ancestry to Dementia: African iPSC Initiative.

Maina, MB., et al.
2025,  
Nature communications

regionalpcs improve discovery of DNA methylation associations with complex traits.

Eulalio, T., et al.
2025,  
Journal of medical imaging (Bellingham, Wash.)

Learning disentangled representations to harmonize connectome network measures.

Newlin, NR., et al.
2025,  
Alzheimer's research & therapy

Plasma phospho-tau217 as a predictive biomarker for Alzheimer's disease in a large south American cohort.

Pandey, N., et al.
2025,  
International journal of medical informatics

Modeling the impact of socioeconomic disparity, biological markers and environmental exposures on phenotypic age using mediation analysis and structural equation models.

Pala, D., et al.
2025,  
Radiology

Open-Source Large Language Models in Radiology: A Review and Tutorial for Practical Research and Clinical Deployment.

Savage, CH., et al.
2025,  
Computers in biology and medicine

Generalizable self-supervised learning for brain CTA in acute stroke.

Dong, Y., et al.
2025,  
Nature communications

Meta-EA: a gene-specific combination of available computational tools for predicting missense variant effects.

Katsonis, P.
2025,  
Genetic epidemiology

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Current opinion in chemical biology

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Genome-wide scan of Flortaucipir PET levels finds JARID2 associated with cerebral tau deposition.

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A genetic and proteomic comparison of key AD biomarkers across tissues.

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Chromosome X-wide association study in case control studies of pathologically confirmed Alzheimer's disease in a European population.

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2024,  
Communications biology

AutoFocus: a hierarchical framework to explore multi-omic disease associations spanning multiple scales of biomolecular interaction.

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Nature communications

Genetic, transcriptomic, histological, and biochemical analysis of progressive supranuclear palsy implicates glial activation and novel risk genes.

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Translational psychiatry

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Alzheimer's & dementia : the journal of the Alzheimer's Association

Admixture mapping of cognitive function in diverse Hispanic and Latino adults: Results from the Hispanic Community Health Study/Study of Latinos.

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Alzheimer's & dementia : the journal of the Alzheimer's Association

A genome-wide association meta-analysis of all-cause and vascular dementia.

2024,  
Alzheimer's & dementia : the journal of the Alzheimer's Association

Leptin bioavailability and markers of brain atrophy and vascular injury in the middle age.

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Communications biology

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Alzheimer's & dementia : the journal of the Alzheimer's Association

Revised criteria for diagnosis and staging of Alzheimer's disease: Alzheimer's Association Workgroup.

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Nature medicine

Revised criteria for the diagnosis and staging of Alzheimer's disease.

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Alzheimer's & dementia : the journal of the Alzheimer's Association

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Alzheimer's disease protective allele of Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication.

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Alzheimer's & dementia : the journal of the Alzheimer's Association

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Alzheimer's & dementia : the journal of the Alzheimer's Association

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Alzheimer's & dementia : the journal of the Alzheimer's Association

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2024,  
medRxiv : the preprint server for health sciences

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bioRxiv : the preprint server for biology

Amyloid, Tau, and APOE in Alzheimer's Disease: Impact on White Matter Tracts.

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JMIR aging

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Annual review of biomedical data science

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medRxiv : the preprint server for health sciences

Connecting intermediate phenotypes to disease using multi-omics in heart failure.

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Single-nucleus multiome analysis of human cerebellum in Alzheimer's disease-related dementia.

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Molecular psychiatry

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Single-nucleus multiomics reveals the disrupted regulatory programs in three brain regions of sporadic early-onset Alzheimer's disease.

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medRxiv : the preprint server for health sciences

Structural variants linked to Alzheimer's Disease and other common age-related clinical and neuropathologic traits.

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bioRxiv : the preprint server for biology

Scupa: Single-cell unified polarization assessment of immune cells using the single-cell foundation model.

Liu, W.
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medRxiv : the preprint server for health sciences

Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries.

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Acta neuropathologica

Epigenetic and genetic risk of Alzheimer disease from autopsied brains in two ethnic groups.

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bioRxiv : the preprint server for biology

BLEND: Probabilistic Cellular Deconvolution with Automated Reference Selection.

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Alzheimer's & dementia : the journal of the Alzheimer's Association

Extended genome-wide association study employing the African genome resources panel identifies novel susceptibility loci for Alzheimer's disease in individuals of African ancestry.

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Targeted co-expression networks for the study of traits.

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medRxiv : the preprint server for health sciences

A Specialized Reference Panel with Structural Variants Integration for Improving Genotype Imputation in Alzheimer's Disease and Related Dementias (ADRD).

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Alzheimer's & dementia : the journal of the Alzheimer's Association

Concurrent nutrient deficiencies are associated with dementia incidence.

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Stem cell research & therapy

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Journal of medical imaging (Bellingham, Wash.)

Characterizing patterns of diffusion tensor imaging variance in aging brains.

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Biological psychiatry

A Single-Nucleus Transcriptome-Wide Association Study Implicates Novel Genes in Depression Pathogenesis.

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Annals of neurology

Evaluating the Effect of Alzheimer's Disease-Related Biomarker Change in Corticobasal Syndrome and Progressive Supranuclear Palsy.

Garcia-Cordero, I., et al.
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Alzheimer's & dementia : the journal of the Alzheimer's Association

Expansion of highly interferon-responsive T cells in early-onset Alzheimer's disease.

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Dementia Prevalence and Onchocerca volvulus Infection among Rural Elderly Persons in the Ntui Health District, Cameroon: A Population-Based Study.

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ArXiv

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JMIR biomedical engineering

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medRxiv : the preprint server for health sciences

GRPa-PRS: A risk stratification method to identify genetically-regulated pathways in polygenic diseases.

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HGG advances

DeepFace: Deep-learning-based framework to contextualize orofacial-cleft-related variants during human embryonic craniofacial development.

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Nature communications

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Human brain mapping

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Alzheimer's research & therapy

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Multiparameter cortical surface morphology in former amateur contact sport athletes.

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Alzheimer's & dementia : the journal of the Alzheimer's Association

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medRxiv : the preprint server for health sciences

A Comprehensive Head-to-Head Comparison of Key Plasma Phosphorylated Tau 217 Biomarker Tests.

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Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel disease.

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Ubiquitin-Proteasome System in the Different Stages of Dominantly Inherited Alzheimer's Disease.

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Environmental science & technology

High-Resolution Mass Spectrometry for Human Exposomics: Expanding Chemical Space Coverage.

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medRxiv : the preprint server for health sciences

Ancestry specific distribution of LPA Kringle IV-Type-2 genetic variants highlight associations to apo(a) copy number, glucose, and hypertension.

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Alzheimer's & dementia : the journal of the Alzheimer's Association

Considerations for the use of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) in cross-country comparisons of cognitive aging and dementia.

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Alzheimer's & dementia : the journal of the Alzheimer's Association

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Field-of-view extension for brain diffusion MRI via deep generative models.

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Neuron

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Midkine Attenuates Aβ Fibril Assembly and AmyloidPlaque Formation.

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Trends in cell biology

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Hormones and behavior

Androgen regulation of behavioral stress responses and the hypothalamic-pituitary-adrenal axis.

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bioRxiv : the preprint server for biology

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Multiple Chronic Conditions and Disability among Vietnamese Older Adults: Results from the Vietnamese Aging and Care Survey (VACS).

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Annals of neurology

Prevalence of and Annual Conversion Rates to Mild Cognitive Impairment and Dementia: Prospective, Longitudinal Study of an Essential Tremor Cohort.

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Alzheimer's & dementia : the journal of the Alzheimer's Association

α-Synuclein seed amplification assay detects Lewy body co-pathology in autosomal dominant Alzheimer's disease late in the disease course and dependent on Lewy pathology burden.

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JAMA neurology

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Nature reviews. Neurology

The Miami Framework for ALS and related neurodegenerative disorders: an integrated view of phenotype and biology.

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IEEE transactions on neural networks and learning systems

Contrastive Brain Network Learning via Hierarchical Signed Graph Pooling Model.

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Evaluation of enzyme activity predictions for variants of unknown significance in Arylsulfatase A.

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Journal of the American Heart Association

Bidirectional Association Between Atrial Fibrillation and Myocardial Infarction, and Relation to Mortality in the Framingham Heart Study.

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Journal of medical Internet research

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Bioinformatics (Oxford, England)

KRAGEN: a knowledge graph-enhanced RAG framework for biomedical problem solving using large language models.

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Molecular neurodegeneration

Anti-acetylated-tau immunotherapy is neuroprotective in tauopathy and brain injury.

Parra Bravo, C., et al.
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Annals of statistics

ON BLOCKWISE AND REFERENCE PANEL-BASED ESTIMATORS FOR GENETIC DATA PREDICTION IN HIGH DIMENSIONS.

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medRxiv : the preprint server for health sciences

Benchmarking of a multi-biomarker low-volume panel for Alzheimer's Disease and related dementia research.

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Nature communications

Gliovascular transcriptional perturbations in Alzheimer's disease reveal molecular mechanisms of blood brain barrier dysfunction.

2024,  
bioRxiv : the preprint server for biology

Sex, racial, and APOE-ε4 allele differences in longitudinal white matter microstructure in multiple cohorts of aging and Alzheimer's disease.

Peterson, A., et al.
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Alzheimer's & dementia : the journal of the Alzheimer's Association

Metabolomics profiling reveals distinct, sex-specific signatures in serum and brain metabolomes in mouse models of Alzheimer's disease.

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Novel early-onset Alzheimer-associated genes influence risk through dysregulation of glutamate, immune activation, and intracell signaling pathways.

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The neuroradiology journal

Association of brain arterial diameters with demographic and anatomical factors in a multi-national pooled analysis of cohort studies.

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Alzheimer's & dementia : the journal of the Alzheimer's Association

The 2022 symposium on dementia and brain aging in low- and middle-income countries: Highlights on research, diagnosis, care, and impact.

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Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Neurotoxic Microglial Activation via IFNγ-Induced Nrf2 Reduction Exacerbating Alzheimer's Disease.

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bioRxiv : the preprint server for biology

regionalpcs: improved discovery of DNA methylation associations with complex traits.

Eulalio, T., et al.
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A transient brain endothelial translatome response to endotoxin is associated with mild cognitive changes post-shock in young mice.

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The Lancet. Neurology

Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer's disease: a cross-sectional study.

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JAMA psychiatry

Genetic and Clinical Correlates of AI-Based Brain Aging Patterns in Cognitively Unimpaired Individuals.

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Journal of translational medicine

Deep learning imaging phenotype can classify metabolic syndrome and is predictive of cardiometabolic disorders.

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bioRxiv : the preprint server for biology

Automated Cytometric Gating with Human-Level Performance Using Bivariate Segmentation.

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LRRK2 G2019S variant is associated with transcriptional changes in Parkinson's disease human myeloid cells under proinflammatory environment.

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Generalizing Parkinson's disease detection using keystroke dynamics: a self-supervised approach.

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PLoS genetics

iGWAS: Image-based genome-wide association of self-supervised deep phenotyping of retina fundus images.

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Proceedings of machine learning research

Online Bilevel Optimization: Regret Analysis of Online Alternating Gradient Methods.

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Proceedings. IEEE International Symposium on Biomedical Imaging

MAPPING ALZHEIMER'S DISEASE PSEUDO-PROGRESSION WITH MULTIMODAL BIOMARKER TRAJECTORY EMBEDDINGS.

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Proceedings. IEEE International Symposium on Biomedical Imaging

MULTISCALE ESTIMATION OF MORPHOMETRICITY FOR REVEALING NEUROANATOMICAL BASIS OF COGNITIVE TRAITS.

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Cell reports

Systematic characterization of multi-omics landscape between gut microbial metabolites and GPCRome in Alzheimer's disease.

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Montelukast as a repurposable additive drug for standard-efficacy multiple sclerosis treatment: Emulating clinical trials with retrospective administrative health claims data.

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JAMA network open

Plasma Leptin and Alzheimer Protein Pathologies Among Older Adults.

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Alzheimer's & dementia : the journal of the Alzheimer's Association

Key variants via the Alzheimer's Disease Sequencing Project whole genome sequence data.

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medRxiv : the preprint server for health sciences

SR-TWAS: Leveraging Multiple Reference Panels to Improve TWAS Power by Ensemble Machine Learning.

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Communications biology

Supervised latent factor modeling isolates cell-type-specific transcriptomic modules that underlie Alzheimer's disease progression.

Hodgson, L., et al.
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Science advances

Brain cell-type shifts in Alzheimer's disease, autism, and schizophrenia interrogated using methylomics and genetics.

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eLife

Biobank-wide association scan identifies risk factors for late-onset Alzheimer's disease and endophenotypes.

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Briefings in bioinformatics

CWAS-Plus: estimating category-wide association of rare noncoding variation from whole-genome sequencing data with cell-type-specific functional data.

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Nature communications

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Cell reports. Medicine

Genetic variants for head size share genes and pathways with cancer.

Knol, MJ., et al.
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Life science alliance

A comparative study of structural variant calling in WGS from Alzheimer's disease families.

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Human brain mapping

Diffusion MRI harmonization via personalized template mapping.

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Neuron

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Strickland, MR., et al.
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The Journal of experimental medicine

Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy.

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Journal of proteome research

Profiling Protein-Protein Interactions in the Human Brain by Refined Cofractionation Mass Spectrometry.

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PLoS biology

Brain high-throughput multi-omics data reveal molecular heterogeneity in Alzheimer's disease.

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Nature neuroscience

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Neuroinformatics

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Kanakaraj, P., et al.
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Alzheimer's & dementia : the journal of the Alzheimer's Association

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Sleep medicine

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JAMA network open

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medRxiv : the preprint server for health sciences

Gene specific effects on brain volume and cognition of TMEM106B in frontotemporal lobar degeneration.

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Alzheimer's & dementia : the journal of the Alzheimer's Association

More than a piece of cake: Noun classifier processing in primary progressive aphasia.

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Alzheimer's & dementia : the journal of the Alzheimer's Association

Data stewardship in FTLD research: Investigator and research participant views.

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Biostatistics (Oxford, England)

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PLoS genetics

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Unveiling Gene Interactions in Alzheimer's Disease by Integrating Genetic and Epigenetic Data with a Network-Based Approach.

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TOPMed imputed genomics enhances genomic atlas of the human proteome in brain, cerebrospinal fluid, and plasma.

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Comparative gene regulatory networks modulating APOE expression in microglia and astrocytes.

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CWAS-Plus: Estimating category-wide association of rare noncoding variation from whole-genome sequencing data with cell-type-specific functional data.

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Alzheimer's & dementia : the journal of the Alzheimer's Association

Whole genome-wide sequence analysis of long-lived families (Long-Life Family Study) identifies MTUS2 gene associated with late-onset Alzheimer's disease.

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Acta neuropathologica

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medRxiv : the preprint server for health sciences

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Alzheimer's & dementia : the journal of the Alzheimer's Association

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The Role of X Chromosome in Alzheimer's Disease Genetics.

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Alzheimer's & dementia : the journal of the Alzheimer's Association

Lewy body dementia: Overcoming barriers and identifying solutions.

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Network medicine informed multi-omics integration identifies drug targets and repurposable medicines for Amyotrophic Lateral Sclerosis.

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Single-Cell Transcriptomics Reveals Pre-existing COVID-19 Vulnerability Factors in Lung Cancer Patients.

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Bioinformatics (Oxford, England)

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bioRxiv : the preprint server for biology

Inferring a directed acyclic graph of phenotypes from GWAS summary statistics.

Zilinskas, R., et al.
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medRxiv : the preprint server for health sciences

Cross-phenotype associations between Alzheimer's Disease and its comorbidities may provide clues to progression.

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BMC medical informatics and decision making

Predicting multiple sclerosis severity with multimodal deep neural networks.

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International journal of environmental research and public health

Precision Recruitment and Engagement of Individuals at Risk for Diabetes and Hypertension in Clinical Trials (PREDHICT): A Randomized Trial for an E-Persuasive Mobile Application to Inform Decision Making about Clinical Trials.

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EBioMedicine

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EBioMedicine

Circular-SWAT for deep learning based diagnostic classification of Alzheimer's disease: application to metabolome data.

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Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology

A Preliminary Study on the Potential Protective Role of the Antioxidative Stress Markers of Cognitive Impairment: Glutathione and Glutathione Reductase.

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miR-129-5p as a biomarker for pathology and cognitive decline in Alzheimer's disease.

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medRxiv : the preprint server for health sciences

A 3'UTR Insertion Is a Candidate Causal Variant at the TMEM106B Locus Associated with Increased Risk for FTLD-TDP.

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Journal of the American Heart Association

Genome-Wide Association Study of Cardiovascular Resilience Identifies Protective Variation in the CETP Gene.

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PLoS genetics

Transfer learning with false negative control improves polygenic risk prediction.

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Alzheimer's & dementia : the journal of the Alzheimer's Association

A haptoglobin (HP) structural variant alters the effect of APOE alleles on Alzheimer's disease.

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Alzheimer's & dementia : the journal of the Alzheimer's Association

Alzheimer's disease heterogeneity explained by polygenic risk scores derived from brain transcriptomic profiles.

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Neurobiology of aging

An Alzheimer's disease risk variant in TTC3 modifies the actin cytoskeleton organization and the PI3K-Akt signaling pathway in iPSC-derived forebrain neurons.

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Bioinformatics (Oxford, England)

hipFG: high-throughput harmonization and integration pipeline for functional genomics data.

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INPP5D regulates inflammasome activation in human microglia.

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Communications biology

Identification of circulating proteins associated with general cognitive function among middle-aged and older adults.

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medRxiv : the preprint server for health sciences

Polygenic burden of short tandem repeat expansions promote risk for Alzheimer's disease.

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medRxiv : the preprint server for health sciences

Research participants' perception of ethical issues in stroke genomics and neurobiobanking research in Africa.

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Alzheimer's & dementia : the journal of the Alzheimer's Association

Predicting cognitive stage transition using p-tau181, Centiloid, and other measures.

Kwon, HS., et al.
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Neurobiology of aging

Amyloid and tau pathology are associated with cerebral blood flow in a mixed sample of nondemented older adults with and without vascular risk factors for Alzheimer's disease.

Swinford, CG., et al.
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Genome medicine

Multivariate GWAS of Alzheimer's disease CSF biomarker profiles implies GRIN2D in synaptic functioning.

Neumann, A., et al.
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bioRxiv : the preprint server for biology

Effect of altered production and storage of dopamine on development and behavior in C. elegans.

Lee, I., et al.
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HGG advances

Founder population-specific weights yield improvements in performance of polygenic risk scores for Alzheimer disease in the Midwestern Amish.

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Genes

Genome-Wide Association Analysis across Endophenotypes in Alzheimer's Disease: Main Effects and Disease Stage-Specific Interactions.

Rosewood, TJ., et al.
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Structural Variation Detection and Association Analysis of Whole-Genome-Sequence Data from 16,905 Alzheimer's Diseases Sequencing Project Subjects.

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Computational diffusion MRI : MICCAI Workshop

FASSt : Filtering via Symmetric Autoencoder for Spherical Superficial White Matter Tractography.

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Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention

Shape-Aware 3D Small Vessel Segmentation with Local Contrast Guided Attention.

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Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention

Personalized Patch-based Normality Assessment of Brain Atrophy in Alzheimer's Disease.

Zhang, J.
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Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention

Uncovering Heterogeneity in Alzheimer's Disease from Graphical Modeling of the Tau Spatiotemporal Topography.

Yue, J.
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Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention

Flow-based Geometric Interpolation of Fiber Orientation Distribution Functions.

Nie, X.
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Neurology

Retrospective Evaluation of Neuropathologic Proxies of the Minimal Atrophy Subtype Compared With Corticolimbic Alzheimer Disease Subtypes.

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Deconvolution reveals cell-type-specific transcriptomic changes in the aging mouse brain.

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Molecular neurodegeneration

Regulation of cortical hyperexcitability in amyotrophic lateral sclerosis: focusing on glial mechanisms.

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bioRxiv : the preprint server for biology

A deep neural network estimation of brain age is sensitive to cognitive impairment and decline.

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Annals of neurology

Network Connectivity Alterations across the MAPT Mutation Clinical Spectrum.

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An ANXA11 P93S variant dysregulates TDP-43 and causes corticobasal syndrome.

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Human brain mapping

Style transfer generative adversarial networks to harmonize multisite MRI to a single reference image to avoid overcorrection.

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Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention

Bidirectional Mapping with Contrastive Learning on Multimodal Neuroimaging Data.

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bioRxiv : the preprint server for biology

The human microglia responsome: a resource to better understand microglia states in health and disease.

Snijders, GJLJ., et al.
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Large-scale causal discovery using interventional data sheds light on the regulatory network architecture of blood traits.

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A BOOTSTRAP MODEL COMPARISON TEST FOR IDENTIFYING GENES WITH CONTEXT-SPECIFIC PATTERNS OF GENETIC REGULATION.

Malakhov, MM., et al.
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Clinical epigenetics

Multi-tissue epigenetic analysis identifies distinct associations underlying insulin resistance and Alzheimer's disease at CPT1A locus.

Sarnowski, C., et al.
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Methods (San Diego, Calif.)

Preference matrix guided sparse canonical correlation analysis for mining brain imaging genetic associations in Alzheimer's disease.

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NeuroImage

Brain-wide genome-wide colocalization study for integrating genetics, transcriptomics and brain morphometry in Alzheimer's disease.

Bao, J., et al.
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medRxiv : the preprint server for health sciences

Characterizing Treatment Non-responders vs. Responders in Completed Alzheimer's Disease Clinical Trials.

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Neuron

Blood-based biomarkers for Alzheimer's disease: Current state and future use in a transformed global healthcare landscape.

Hampel, H., et al.
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Alzheimer's & dementia : the journal of the Alzheimer's Association

Genetic associations with age at dementia onset in the PSEN1 E280A Colombian kindred.

Cochran, JN., et al.
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Nature medicine

Emerging diagnostics and therapeutics for Alzheimer disease.

Self, WK.
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APL bioengineering

Direct differentiation of human pluripotent stem cells into vascular network along with supporting mural cells.

Bertucci, T., et al.
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Nature communications

Single cell multiomic analysis reveals diabetes-associated β-cell heterogeneity driven by HNF1A.

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Briefings in bioinformatics

scMultiGAN: cell-specific imputation for single-cell transcriptomes with multiple deep generative adversarial networks.

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Synthetic OCT-A blood vessel maps using fundus images and generative adversarial networks.

Coronado, I., et al.
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ArXiv

Genetic InfoMax: Exploring Mutual Information Maximization in High-Dimensional Imaging Genetics Studies.

Xie, Y., et al.
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Journal of the American Heart Association

Evolutionary Action-Machine Learning Model Identifies Candidate Genes Associated With Early-Onset Coronary Artery Disease.

Shapiro, D., et al.
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Statistics in medicine

Deep causal feature extraction and inference with neuroimaging genetic data.

Yao, Y., et al.
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Nature reviews. Cardiology

The bidirectional association between atrial fibrillation and myocardial infarction.

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Adherence type impacts completion rates of frequent mobile cognitive assessments among older adults with and without cognitive impairment.

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Multi-Group Tensor Canonical Correlation Analysis.

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Genetic overlap between Alzheimer's disease and immune-mediated diseases: An atlas of shared genetic determinants and biological convergence.

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Effects of Vascular Risk Factors on the Association of Blood-Based Biomarkers with Alzheimer's Disease.

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BMC bioinformatics

Bulk brain tissue cell-type deconvolution with bias correction for single-nuclei RNA sequencing data using DeTREM.

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Alzheimer's & dementia : the journal of the Alzheimer's Association

The Early-Onset Alzheimer's Disease Whole-Genome Sequencing Project: Study design and methodology.

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JAMA neurology

Associations of Sex, Race, and Apolipoprotein E Alleles With Multiple Domains of Cognition Among Older Adults.

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Sex- and APOE-specific genetic risk factors for late-onset Alzheimer's disease: Evidence from gene-gene interaction of longevity-related loci.

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The impact of blood MCP-1 levels on Alzheimer's disease with genetic variation of UNC5C and NAV3 loci.

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medRxiv : the preprint server for health sciences

Association of Common and Rare Variants with Alzheimer's Disease in over 13,000 Diverse Individuals with Whole-Genome Sequencing from the Alzheimer's Disease Sequencing Project.

Lee, W., et al.
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medRxiv : the preprint server for health sciences

Structural Variation Detection and Association Analysis of Whole-Genome-Sequence Data from 16,905 Alzheimer's Diseases Sequencing Project Subjects.

Wang, H., et al.
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Alzheimer's & dementia : the journal of the Alzheimer's Association

Ancestry-related differences in chromatin accessibility and gene expression of APOE ε4 are associated with Alzheimer's disease risk.

Celis, K., et al.
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International journal of geriatric psychiatry

Neuropsychiatric features in a multi-ethnic population with Alzheimer disease and mild cognitive impairment.

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Alzheimer's research & therapy

The association of circulating endocannabinoids with neuroimaging and blood biomarkers of neuro-injury.

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Evaluation of Neighborhood-Level Disadvantage and Cognition in Mexican American and Non-Hispanic White Adults 50 Years and Older in the US.

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Dissecting Detergent-Insoluble Proteome in Alzheimer's Disease by TMTc-Corrected Quantitative Mass Spectrometry.

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Stem cell research & therapy

APOE deficiency impacts neural differentiation and cholesterol biosynthesis in human iPSC-derived cerebral organoids.

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Nature communications

Whole genome deconvolution unveils Alzheimer's resilient epigenetic signature.

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Neuron

An astrocyte BMAL1-BAG3 axis protects against alpha-synuclein and tau pathology.

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Biology of sex differences

Sex differences in metabolic phenotype and hypothalamic inflammation in the 3xTg-AD mouse model of Alzheimer's disease.

Robison, LS., et al.
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bioRxiv : the preprint server for biology

Brain Specific Estrogen Ameliorates Cognitive Effects of Surgical Menopause in Mice.

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Multiple sclerosis and related disorders

Targeting miR-223 enhances myeloid-derived suppressor cell suppressive activities in multiple sclerosis patients.

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MidRISH: Unbiased harmonization of rotationally invariant harmonics of the diffusion signal.

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Alzheimer's & dementia : the journal of the Alzheimer's Association

Identification of circRNAs linked to Alzheimer's disease and related dementias.

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Cell reports

Poly(GR) interacts with key stress granule factors promoting its assembly into cytoplasmic inclusions.

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Proceedings of the National Academy of Sciences of the United States of America

The liquid-to-solid transition of FUS is promoted by the condensate surface.

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Cell reports

Cell-type-specific regulation of APOE and CLU levels in human neurons by the Alzheimer's disease risk gene SORL1.

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Nature communications

Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases.

Nutma, E., et al.
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BMJ open

Using community-based geographical information system (GIS) to recruit older Asian Americans in an Alzheimer's disease study.

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The Clinical neuropsychologist

Can the Montreal Cognitive Assessment and Mini-Mental State Examination detect cognitive decline in elderly patients with essential tremor?

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Multimodal nonlinear correlates of behavioural symptoms in frontotemporal dementia.

Zamboni, G., et al.
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bioRxiv : the preprint server for biology

Disrupted excitation-inhibition balance in cognitively normal individuals at risk of Alzheimer's disease.

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Cell genomics

Multiset correlation and factor analysis enables exploration of multi-omics data.

Brown, BC., et al.
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Bioinformatics (Oxford, England)

ShinyBioHEAT: an interactive shiny app to identify phenotype driver genes in E.coli and B.subtilis.

Wang, C., et al.
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Human molecular genetics

Integrating GWAS summary statistics, individual-level genotypic and omic data to enhance the performance for large-scale trait imputation.

Ren, J., et al.
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Journal of econometrics

Distribution-Invariant Differential Privacy.

Bi, X.
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medRxiv : the preprint server for health sciences

AORTA Gene: Polygenic prediction improves detection of thoracic aortic aneurysm.

Pirruccello, JP., et al.
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CPT: pharmacometrics & systems pharmacology

Knowledge graph aids comprehensive explanation of drug and chemical toxicity.

Hao, Y., et al.
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medRxiv : the preprint server for health sciences

Improving Genetic Association Studies with a Novel Methodology that Unveils the Hidden Complexity of All-Cause Heart Failure.

Gregg, JT., et al.
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Proceedings of machine learning research

Fairness-Aware Class Imbalanced Learning on Multiple Subgroups.

Tarzanagh, DA., et al.
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medRxiv : the preprint server for health sciences

Extended genome-wide association study employing the African Genome Resources Panel identifies novel susceptibility loci for Alzheimer's Disease in individuals of African ancestry.

Ray, NR., et al.
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medRxiv : the preprint server for health sciences

Risk of Alzheimer's Disease is Associated with Longitudinal Changes in Plasma Biomarkers in the Multiethnic Washington Heights, Inwood Columbia Aging Project Cohort.

Gu, Y., et al.
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medRxiv : the preprint server for health sciences

Lysophosphatidylcholines are associated with P-tau181 levels in early stages of Alzheimer's Disease.

Kalia, V., et al.
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medRxiv : the preprint server for health sciences

Key variants via Alzheimer's Disease Sequencing Project whole genome sequence data.

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International journal of stroke : official journal of the International Stroke Society

Pleiotropy analysis between lobar intracerebral hemorrhage and CSF β-amyloid highlights new and established associations.

Marini, S., et al.
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Journal of neuropathology and experimental neurology

LATE-NC risk alleles (in TMEM106B, GRN, and ABCC9 genes) among persons with African ancestry.

Katsumata, Y., et al.
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Journal of clinical medicine

Genetics of Alzheimer's Disease in the African American Population.

Logue, MW., et al.
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Alzheimer's & dementia : the journal of the Alzheimer's Association

Genome-wide methylomic regulation of multiscale gene networks in Alzheimer's disease.

Wang, E., et al.
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Alzheimer's & dementia : the journal of the Alzheimer's Association

Obesity impacts the expression of Alzheimer's disease-related genes: The Framingham Heart Study.

Charisis, S., et al.
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Alzheimer's & dementia : the journal of the Alzheimer's Association

Placental growth factor as a sensitive biomarker for vascular cognitive impairment.

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Cerebral small vessel disease burden is associated with decreased abundance of gut Barnesiella intestinihominis bacterium in the Framingham Heart Study.

Fongang, B., et al.
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A Varying Coefficient Model to Jointly Test Genetic and Gene-Environment Interaction Effects.

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Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer's disease.

Inoue, Y., et al.
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bioRxiv : the preprint server for biology

Improved Protocol for Reproducible Human Cortical Organoids Reveals Early Alterations in Metabolism with MAPT Mutations.

Bertucci, T., et al.
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Alzheimer's & dementia : the journal of the Alzheimer's Association

Prediction of neuropathologic lesions from clinical data.

Phongpreecha, T., et al.
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Journal of neurology, neurosurgery, and psychiatry

Plasma inflammation for predicting phenotypic conversion and clinical progression of autosomal dominant frontotemporal lobar degeneration.

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Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

Predictive Modeling Of Alzheimer's Disease Prognosis Using Anatomical & Diffusion MRI.

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Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

Efficiently Training Vision Transformers on Structural MRI Scans for Alzheimer's Disease Detection.

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Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

Evaluating Fiber Orientation Dispersion Measures Computed From Single-Shell Diffusion MRI.

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Acta neuropathologica

Brain DNA methylomic analysis of frontotemporal lobar degeneration reveals OTUD4 in shared dysregulated signatures across pathological subtypes.

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HGG advances

Using GWAS summary data to impute traits for genotyped individuals.

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Circulation. Cardiovascular quality and outcomes

Association Between Electrocardiographic Age and Cardiovascular Events in Community Settings: The Framingham Heart Study.

Brant, LCC., et al.
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Proceedings of the National Academy of Sciences of the United States of America

Slingshot homolog-1-mediated Nrf2 sequestration tips the balance from neuroprotection to neurodegeneration in Alzheimer's disease.

Cazzaro, S., et al.
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Alzheimer's & dementia : the journal of the Alzheimer's Association

A call for clinical trial globalization in Alzheimer's disease and related dementia.

Llibre-Guerra, JJ., et al.
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Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

Association of Central Auditory Processing Dysfunction With Preclinical Alzheimer's Disease.

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NeuroImage

Image harmonization: A review of statistical and deep learning methods for removing batch effects and evaluation metrics for effective harmonization.

Hu, F., et al.
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Human molecular genetics

Genetic architecture of plasma Alzheimer disease biomarkers.

Bradley, J., et al.
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Science translational medicine

Proteomics of brain, CSF, and plasma identifies molecular signatures for distinguishing sporadic and genetic Alzheimer's disease.

Sung, YJ., et al.
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NPJ Parkinson's disease

Proteome wide association studies of LRRK2 variants identify novel causal and druggable proteins for Parkinson's disease.

Phillips, B., et al.
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Alzheimer's & dementia : the journal of the Alzheimer's Association

Prevalence of dementia in India: National and state estimates from a nationwide study.

Lee, J., et al.
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Nature human behaviour

Identifying modifiable factors and their joint effect on dementia risk in the UK Biobank.

Zhang, Y., et al.
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NPJ Regenerative medicine

Nerve growth factor receptor (Ngfr) induces neurogenic plasticity by suppressing reactive astroglial Lcn2/Slc22a17 signaling in Alzheimer's disease.

Siddiqui, T., et al.
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Neurobiology of aging

Inflammatory biomarkers and MRI visible perivascular spaces: The Framingham Heart Study.

Ekenze, O., et al.
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Science translational medicine

Proteomics analysis of plasma from middle-aged adults identifies protein markers of dementia risk in later life.

Walker, KA., et al.
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Nature medicine

Clonal hematopoiesis is associated with protection from Alzheimer's disease.

Bouzid, H., et al.
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HGG advances

Admixture mapping implicates 13q33.3 as ancestry-of-origin locus for Alzheimer disease in Hispanic and Latino populations.

Horimoto, ARVR., et al.
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medRxiv : the preprint server for health sciences

APOE loss-of-function variants: Compatible with longevity and associated with resistance to Alzheimer's Disease pathology.

Chemparathy, A., et al.
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Trends in neurosciences

Moving beyond amyloid and tau to capture the biological heterogeneity of Alzheimer's disease.

Young-Pearse, TL., et al.
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British journal of cancer

Evolution of cisplatin resistance through coordinated metabolic reprogramming of the cellular reductive state.

Yu, W., et al.
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Journal of biomedical informatics

HLA amino acid Mismatch-Based risk stratification of kidney allograft failure using a novel Machine learning algorithm.

Dasariraju, S., et al.
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NPJ digital medicine

A flexible symbolic regression method for constructing interpretable clinical prediction models.

La Cava, WG., et al.
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British journal of pharmacology

Hydrogen sulfide signalling in neurodegenerative diseases.

Tripathi, SJ., et al.
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Alzheimer's & dementia : the journal of the Alzheimer's Association

Social enrichment on the job: Complex work with people improves episodic memory, promotes brain reserve, and reduces the risk of dementia.

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Aging and disease

Serum Adiponectin and In Vivo Brain Amyloid Deposition in Cognitively Normal Older Adults: A Cohort Study.

Kim, JW., et al.
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Alzheimer's research & therapy

Body mass index and two-year change of in vivo Alzheimer's disease pathologies in cognitively normal older adults.

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Unique genetic architecture of CSF and brain metabolites pinpoints the novel targets for the traits of human wellness.

Wang, C., et al.
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Proteogenomic analysis of human cerebrospinal fluid identifies neurologically relevant regulation and informs causal proteins for Alzheimer's disease.

Cruchaga, C., et al.
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Alzheimer's & dementia : the journal of the Alzheimer's Association

APOE and immunity: Research highlights.

Kloske, CM., et al.
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Neurobiology of aging

Multi-omic characterization of brain changes in the vascular endothelial growth factor family during aging and Alzheimer's disease.

Seto, M., et al.
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Modeling of mitochondrial genetic polymorphisms reveals induction of heteroplasmy by pleiotropic disease locus 10398A>G.

Smullen, M., et al.
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Molecular neurodegeneration

A genome-wide search for pleiotropy in more than 100,000 harmonized longitudinal cognitive domain scores.

Kang, M., et al.
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Acta neuropathologica

Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation.

Filipello, F., et al.
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Molecular neurodegeneration

Sex specific molecular networks and key drivers of Alzheimer's disease.

Guo, L., et al.
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Alzheimer's & dementia : the journal of the Alzheimer's Association

Admixture mapping identifies novel Alzheimer's disease risk regions in African Americans.

Rajabli, F., et al.
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Alzheimer's & dementia : the journal of the Alzheimer's Association

AD and non-AD mediators of the pathway between the APOE genotype and cognition.

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STAR protocols

Standardized immunoprecipitation protocol for efficient isolation of native apolipoprotein E particles utilizing HJ15.4 monoclonal antibody.

O'Leary, J., et al.
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Medicine

The SERPINA5 coding variant E228Q does not contribute to clinicopathologic characteristics in Alzheimer's disease: A cross-sectional study.

Matchett, BJ., et al.
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The Journal of cell biology

Autolysosomal exocytosis of lipids protect neurons from ferroptosis.

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Brain : a journal of neurology

The pathotome and precision health.

Younes, K.
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Cell stem cell

Advancing cell therapy for neurodegenerative diseases.

Temple, S.
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Biology of sex differences

Sex differences in the effects of high fat diet on underlying neuropathology in a mouse model of VCID.

Abi-Ghanem, C., et al.
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Biology of sex differences

Menopause causes metabolic and cognitive impairments in a chronic cerebral hypoperfusion model of vascular contributions to cognitive impairment and dementia.

Gannon, OJ., et al.
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Neuropsychology

Harmonizing the preclinical Alzheimer cognitive composite for multicohort studies.

Hampton, OL., et al.
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Alzheimer's & dementia : the journal of the Alzheimer's Association

Association of spermidine plasma levels with brain aging in a population-based study.

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bioRxiv : the preprint server for biology

Leveraging longitudinal diffusion MRI data to quantify differences in white matter microstructural decline in normal and abnormal aging.

Archer, DB., et al.
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Accumulation of m6A exhibits stronger correlation with MAPT than β-amyloid pathology in an APPNL-G-F/MAPTP301S mouse model of Alzheimer's disease

2023,  
medRxiv : the preprint server for health sciences

Single-cell RNA sequencing data reveals rewiring of transcriptional relationships in Alzheimer's Disease associated with risk variants.

Bouland, GA., et al.
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Journal of geriatric psychiatry and neurology

Demographic and Symptom Correlates of Initial Idiopathic Psychiatric Diagnosis in Frontotemporal Dementia.

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Biological psychiatry

Prioritization of Drug Targets for Neurodegenerative Diseases by Integrating Genetic and Proteomic Data From Brain and Blood.

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Evaluation of Plasma Phosphorylated Tau217 for Differentiation Between Alzheimer Disease and Frontotemporal Lobar Degeneration Subtypes Among Patients With Corticobasal Syndrome.

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Explainable machine learning aggregates polygenic risk scores and electronic health records for Alzheimer's disease prediction.

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Association of Life's Simple 7 with incident dementia and its modification by the apolipoprotein E genotype.

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A deep learning framework identifies dimensional representations of Alzheimer's Disease from brain structure.

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Profiling senescent cells in human brains reveals neurons with CDKN2D/p19 and tau neuropathology.

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A missense variant in SHARPIN mediates Alzheimer's disease-specific brain damages.

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KYNA/Ahr Signaling Suppresses Neural Stem Cell Plasticity and Neurogenesis in Adult Zebrafish Model of Alzheimer's Disease.

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BMI1 is associated with CS8F amyloid-β and rates of cognitive decline in Alzheimer's disease.

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Genome-wide association identifies the first risk loci for psychosis in Alzheimer disease.

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Nature aging

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Alzheimer's & dementia : the journal of the Alzheimer's Association

Plasma amyloid β levels are driven by genetic variants near APOE, BACE1, APP, PSEN2: A genome-wide association study in over 12,000 non-demented participants.

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Nature neuroscience

Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders.

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bioRxiv : the preprint server for biology

Weakly activated core inflammation pathways were identified as a central signaling mechanism contributing to the chronic neurodegeneration in Alzheimer's disease.

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Bioinformatics (Oxford, England)

Modeling multifunctionality of genes with secondary gene co-expression networks in human brain provides novel disease insights.

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American journal of epidemiology

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Annals of neurology

Polygenic Risk Score for Alzheimer's Disease in Caribbean Hispanics.

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Analysis of genes (TMEM106B, GRN, ABCC9, KCNMB2, and APOE) implicated in risk for LATE-NC and hippocampal sclerosis provides pathogenetic insights: a retrospective genetic association study.

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Translational psychiatry

Cortical structure and the risk for Alzheimer's disease: a bidirectional Mendelian randomization study.

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Olfactory Bulb and Amygdala Gene Expression Changes in Subjects Dying with COVID-19.

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In vivo and neuropathology data support locus coeruleus integrity as indicator of Alzheimer's disease pathology and cognitive decline.

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Systems Analysis Reveals Ageing-Related Perturbations in Retinoids and Sex Hormones in Alzheimer's and Parkinson's Diseases.

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MicroRNA-195 rescues ApoE4-induced cognitive deficits and lysosomal defects in Alzheimer's disease pathogenesis.

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Nature genetics

A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease.

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Science translational medicine

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Rare variants in the endocytic pathway are associated with Alzheimer's disease, its related phenotypes, and functional consequences.

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Alzheimer's & dementia : the journal of the Alzheimer's Association

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Utilizing a Biology-Driven Approach to Map the Exposome in Health and Disease: An Essential Investment to Drive the Next Generation of Environmental Discovery.

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Neurobiology of aging

Linkage of Alzheimer disease families with Puerto Rican ancestry identifies a chromosome 9 locus.

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Nature genetics

Single-nucleus chromatin accessibility and transcriptomic characterization of Alzheimer's disease.

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Nature chemistry

SARS-CoV-2 simulations go exascale to predict dramatic spike opening and cryptic pockets across the proteome.

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Molecular psychiatry

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Identifying individuals with high risk of Alzheimer's disease using polygenic risk scores.

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New biomarkers from multiomics approaches: improving risk prediction of atrial fibrillation.

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Nature neuroscience

Neuronal ApoE upregulates MHC-I expression to drive selective neurodegeneration in Alzheimer's disease.

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Rare CASP6N73T variant associated with hippocampal volume exhibits decreased proteolytic activity, synaptic transmission defect, and neurodegeneration.

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Using the dCas9-KRAB system to repress gene expression in hiPSC-derived NGN2 neurons.

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Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci.

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Common variants in Alzheimer's disease and risk stratification by polygenic risk scores.

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Exome sequencing revealed PDE11A as a novel candidate gene for early-onset Alzheimer's disease.

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Learning From Clinical Consensus Diagnosis in India to Facilitate Automatic Classification of Dementia: Machine Learning Study.

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Dissecting the role of Amerindian genetic ancestry and the ApoE ε4 allele on Alzheimer disease in an admixed Peruvian population.

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Genetic variants in glutamate-, Aβ-, and tau-related pathways determine polygenic risk for Alzheimer's disease.

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A Non-APOE Polygenic Risk Score for Alzheimer's Disease Is Associated With Cerebrospinal Fluid Neurofilament Light in a Representative Sample of Cognitively Unimpaired 70-Year Olds.

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Increased Alu RNA processing in Alzheimer brains is linked to gene expression changes.

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Multi-tissue neocortical transcriptome-wide association study implicates 8 genes across 6 genomic loci in Alzheimer's disease.

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Genome-wide analysis identifies a novel LINC-PINT splice variant associated with vascular amyloid pathology in Alzheimer's disease.

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NEBULA is a fast negative binomial mixed model for differential or co-expression analysis of large-scale multi-subject single-cell data.

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A Genetic Study of Cerebral Atherosclerosis Reveals Novel Associations with NTNG1 and CNOT3.

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Differentially expressed genes in Alzheimer's disease highlighting the roles of microglia genes including OLR1 and astrocyte gene CDK2AP1.

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Alzheimer's & dementia : the journal of the Alzheimer's Association

Harnessing the paradoxical phenotypes of APOE ɛ2 and APOE ɛ4 to identify genetic modifiers in Alzheimer's disease.

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Artificial intelligence and machine learning-aided drug discovery in central nervous system diseases: State-of-the-arts and future directions.

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Nature aging

Large-scale plasma proteomic analysis identifies proteins and pathways associated with dementia risk.

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African Americans Have Differences in CSF Soluble TREM2 and Associated Genetic Variants.

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Circulation. Genomic and precision medicine

Shared Genetic and Environmental Architecture of Cardiac Phenotypes Assessed via Echocardiography: The Framingham Heart Study.

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Modeling transcriptional regulation using gene regulatory networks based on multi-omics data sources.

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Novel Variance-Component TWAS method for studying complex human diseases with applications to Alzheimer's dementia.

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Mendelian randomization identifies blood metabolites previously linked to midlife cognition as causal candidates in Alzheimer's disease.

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Cell-type-specific expression quantitative trait loci associated with Alzheimer disease in blood and brain tissue.

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Lack of evidence supporting a role for DPP6 sequence variants in Alzheimer's disease in the European American population.

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Reconcile the debate over protective effects of BCG vaccine against COVID-19.

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Alzheimer's & dementia : the journal of the Alzheimer's Association

MarkVCID cerebral small vessel consortium: II. Neuroimaging protocols.

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MarkVCID cerebral small vessel consortium: I. Enrollment, clinical, fluid protocols.

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Asymmetry of Hippocampal Tau Pathology in Primary Age-Related Tauopathy and Alzheimer Disease.

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TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau.

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Alzheimer's & dementia : the journal of the Alzheimer's Association

Long genes are more frequently affected by somatic mutations and show reduced expression in Alzheimer's disease: Implications for disease etiology.

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American journal of human genetics

Genetic control of the human brain proteome.

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Defining early changes in Alzheimer's disease from RNA sequencing of brain regions differentially affected by pathology.

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MOSTWAS: Multi-Omic Strategies for Transcriptome-Wide Association Studies.

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Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders.

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Set-Based Rare Variant Expression Quantitative Trait Loci in Blood and Brain from Alzheimer Disease Study Participants.

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The Impact of Complement Genes on the Risk of Late-Onset Alzheimer's Disease.

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Greater effect of polygenic risk score for Alzheimer's disease among younger cases who are apolipoprotein E-ε4 carriers.

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Integration of Alzheimer's disease genetics and myeloid genomics identifies disease risk regulatory elements and genes.

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Alzheimer's & dementia : the journal of the Alzheimer's Association

APOE alleles' association with cognitive function differs across Hispanic/Latino groups and genetic ancestry in the study of Latinos-investigation of neurocognitive aging (HCHS/SOL).

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Atlas55+: Brain Functional Atlas of Resting-State Networks for Late Adulthood.

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International journal of environmental research and public health

The GGLEAM Study: Understanding Glaucoma in the Ohio Amish.

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Set-based genetic association and interaction tests for survival outcomes based on weighted V statistics.

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Alzheimer's & dementia : the journal of the Alzheimer's Association

Non-coding variants in MYH11, FZD3, and SORCS3 are associated with dementia in women.

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Genetically determined blood pressure, antihypertensive medications, and risk of Alzheimer's disease: a Mendelian randomization study.

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Tailor: Targeting heavy tails in flow cytometry data with fast, interpretable mixture modeling.

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Long runs of homozygosity are associated with Alzheimer's disease.

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Exome-wide age-of-onset analysis reveals exonic variants in ERN1 and SPPL2C associated with Alzheimer's disease.

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Diversified transcriptional responses of myeloid and glial cells in spinal cord injury shaped by HDAC3 activity.

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Association of Circulating Metabolites in Plasma or Serum and Risk of Stroke: Meta-analysis From 7 Prospective Cohorts.

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Integrating Transcriptomics, Genomics, and Imaging in Alzheimer's Disease: A Federated Model.

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Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention

Disentangled and Proportional Representation Learning for Multi-View Brain Connectomes.

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Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention

Style Transfer Using Generative Adversarial Networks for Multi-Site MRI Harmonization.

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Potential Novel Genes for Late-Onset Alzheimer's Disease in East-Asian Descent Identified by APOE-Stratified Genome-Wide Association Study.

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Association of Dietary Prebiotic Consumption with Reduced Risk of Alzheimer's Disease in a Multiethnic Population.

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The Association of Cognitive and Visual Function in a Nationally Representative Study of Older Adults in India.

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Heart & lung : the journal of critical care

Testing influences of APOE and BDNF genes and heart failure on cognitive function.

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A prospective cohort study of prodromal Alzheimer's disease: Prospective Imaging Study of Ageing: Genes, Brain and Behaviour (PISA).

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Polygenic risk scores for Alzheimer's disease are related to dementia risk in APOE ɛ4 negatives.

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Five-Year Change in Body Mass Index Predicts Conversion to Mild Cognitive Impairment or Dementia Only in APOE ɛ4 Allele Carriers.

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Defining functional variants associated with Alzheimer's disease in the induced immune response.

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Journal of neurogenetics

Analysis of whole genome sequenced cases and controls shows that the association of variants in TOMM40, BCAM, NECTIN2 and APOC1 with late onset Alzheimer's disease is driven by linkage disequilibrium with APOE ε2/ε3/ε4 alleles.

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Transfer learning-trained convolutional neural networks identify novel MRI biomarkers of Alzheimer's disease progression.

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Similar Genetic Architecture of Alzheimer's Disease and Differential APOE Effect Between Sexes.

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Longitudinal Body Weight Change, Visit-To-Visit Body Weight Fluctuation, and Cognitive Decline Among Older Adults.

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Using INFERNO to Infer the Molecular Mechanisms Underlying Noncoding Genetic Associations.

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Association of neurogranin gene expression with Alzheimer's disease pathology in the perirhinal cortex.

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Polygenic score modifies risk for Alzheimer's disease in APOE ε4 homozygotes at phenotypic extremes.

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Cognitive screening with functional assessment improves diagnostic accuracy and attenuates bias.

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Herpes Labialis, Chlamydophila pneumoniae, Helicobacter pylori, and Cytomegalovirus Infections and Risk of Dementia: The Framingham Heart Study.

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Copy Number Variation Identification on 3,800 Alzheimer's Disease Whole Genome Sequencing Data from the Alzheimer's Disease Sequencing Project.

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Large-scale sequencing studies expand the known genetic architecture of Alzheimer's disease.

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A White Matter Connection of Schizophrenia and Alzheimer's Disease.

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The Brain Chart of Aging: Machine-learning analytics reveals links between brain aging, white matter disease, amyloid burden, and cognition in the iSTAGING consortium of 10,216 harmonized MR scans.

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A Systematic Review of Delirium Biomarkers and Their Alignment with the NIA-AA Research Framework.

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Positive Psychosocial Factors and Cognitive Decline in Ethnically Diverse Older Adults.

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