Mediating effect of pro-inflammatory cytokines in the association between depression, anxiety, and cardiometabolic disorders in an ethnically diverse middle-aged and older population.

Neuroinflammation has been significantly associated with depression and anxiety, both of which are significantly associated with higher cardiometabolic risk. Systemic inflammation was also commonly described in patients with cardiometabolic disorders. It is thus unclear whether pro-inflammatory cytokines might mediate the effect between depression, anxiety, and cardiometabolic disorders, particularly in advanced ages.