Preclinical Alzheimer’s disease shows alterations in circulating neuronal-derived extracellular vesicle microRNAs in a multiethnic cohort.

Alzheimer’s disease (AD) is the leading cause of dementia, affecting around 50 million individuals worldwide. Brain-derived extracellular vesicles (EVs) can cross the blood-brain barrier carrying neuron-specific molecules, such as microRNAs (miRNAs), which have potential as biomarkers of neurodegeneration.