Shared genetics and causal association between plasma levels of SARS-CoV-2 entry receptor ACE2 and Alzheimer’s disease.

Alzheimer’s disease (AD) is the highest risk of COVID-19 infection, hospitalization, and mortality. However, it remains largely unclear about the link between AD and COVID-19 outcomes. ACE2 is an entry receptor for SARS-CoV-2. Circulating ACE2 is a novel biomarker of death and associated with COVID-19 outcomes.