Subscale validation of the neuropsychiatric inventory questionnaire: comparison of Alzheimer’s disease neuroimaging initiative and national Alzheimer’s coordinating center cohorts.

Neuropsychiatric symptoms are prevalent in mild cognitive impairment (MCI) and Alzheimer disease (AD) and commonly measured using the Neuropsychiatric Inventory (NPI). Based on existing exploratory literature, we report preliminary validation of three NPI Questionnaire (NPI-Q-10) subscales that measure clinically meaningful symptom clusters.