The impact of arteriolosclerosis on cognitive impairment in decedents without severe dementia from the National Alzheimer’s Coordinating Center.

Alzheimer’s disease neuropathologic change (ADNC), Lewy body disease (LBD), and vascular neuropathologies occur together. Previous studies have been limited by a large majority of participants with severe dementia or advanced stages of pathologies, which limits the detectability of cognitive effects from vascular neuropathologies.