Association of APOE alleles and polygenic profiles comprising APOE-TOMM40-APOC1 variants with Alzheimer’s disease neuroimaging markers.

TOMM40 and APOC1 variants can modulate the APOE-ε4-related Alzheimer’s disease (AD) risk by up to fourfold. We aim to investigate whether the genetic modulation of ε4-related AD risk is reflected in brain morphology.