Interactions between menopause and high-fat diet on cognition and pathology in a mouse model of Alzheimer’s disease.

Post-menopausal women constitute about two-thirds of those with Alzheimer’s disease (AD). Menopause increases dementia risk by heightening the likelihood of metabolic disease, a well-known risk factor for dementia. We aimed to determine the effects of menopause and high-fat diet (HF) on cognitive and pathological outcomes in an AD mouse model.