Compared to non-Latino White adults, Mexican Americans in the United States are disproportionally exposed to more social, environmental, and economic stress that increase risk for poor physical and mental health outcomes. Despite this, Mexican Americans tend to benefit from a mortality and mental health advantage indicative of unique resilience and risk factors. We assessed stress exposure and appraisals in eight domains among Mexican Americans compared to non-Latino Whites, and evaluated if compared to high acculturation, low acculturation may be associated with lower stress exposure and appraisal in Mexican Americans.